Tadachem-20 Aurochem treat erectile dysfunction (2 blisters x 2 tablets)

Dosage form Box of 2 blisters x 2 tablets
Specifications Tadalafil

Ingredient

Composition information	Content
Tadalafil	20mg

Uses

indications

Tadachem 20 drugs are indicated in the following cases:

Treatment in cases of erectile dysfunction in adult men.

Pharmacokology

Tadalafil is a selective inhibitor, with restoration of Guanosin Monophosphate (CGMP), especially phosphodiesterase type 5 (PDE5). When sexual stimulation leads to on -site nitric release, the PDE5 inhibitor of Tadalafil increases the CGMP concentration in the cave. The result of smooth muscle relaxes and increases blood flow into the penis tissue, thereby causing penis. When there is no sexual stimulation, Tadalafil does not work.

pharmacokinetics

Tadalafil absorb well after drinking. The peak concentration of plasma is achieved within 2 hours, the speed and level of absorption are not affected by food. Tadalafil is widely distributed to tissues and about 94% connected to plasma proteins. The drug is metabolized mainly in the liver through Cytochrom P450 ISOENZYM CYP3A4.

Methylcatechol Glucuronid is not active. Tadalafil's average disposal time is about 17.5 hours. Tadalafil is eliminated mainly in the form of metabolites (61% of the dose) and urine (36% of the dose of use). The clearance of the elderly and patients with kidney failure.

Before taking Tadachem-20 Aurochem treat erectile dysfunction (2 blisters x 2 tablets)

How to use

oral medication, can be taken before or after meals with a glass of water.

In case of taking the drug when needed, taking the drug at least 30 minutes before sex and not related to the meal.

Dosage

Tadalafil's dose is recommended 10 mg before sexual activity. In the case of the non -effective tadalafil 10 mg dose, the dose of 20 mg may be increased.

Patients with liver failure

In patients with mild to moderate liver failure, the maximum dose must not exceed 10 mg once a day. Do not use tadalafil for patients with severe liver failure.

Patients with renal failure

In patients with medium renal failure (creatinine clearance from 31 - 50 ml/minute), start at a dose of 5 mg not exceeding once a day, maximum dose not exceeding 10 mg once every 48 hours. In patients with severe renal impairment (creatinine clearance below 30 ml/minute) and patients are hemolysis, the maximum dose must not exceed 5 mg once a day.

Patients have stabilized with Alpha receptor blockers, which should be used with Tadalafil at a starting dose of 5 mg.

Patients use strong Cytochrom P450 ISOENZYM CYP3A4, should not use Tadalafil more than 10 mg once every 72 hours.

Children

Not recommended for children under 18 years old.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? Bloody decentralization contributes negligible to the elimination of Tadalafil.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Tadachem 20, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Nervous system: headache.

circuit: redness.

Respiratory: Nose congestion.

digestive: indigestion, gastroesophageal reflux - esophagus.

Muscle, connective tissue and bone: back pain, muscle pain, limbs.

Uncommon, 1/1000

The immune system: Hypersensitivity reactions.

Nervous system: Stunned.

Eyes: blurred vision, eye pain.

Tinnitus.

Heart: tachycardia, brushing chest drum.

Hematuria (when taking anti -hypertension drugs), hypertension.

Respiratory: Difficulty breathing, nosebleeds.

digestive: abdominal pain.

Skin and subcutaneous tissue: rash, increased sweating.

Kidney and urinary: urinating bleeding.

Reproduction system: penis bleeding, blood semen.

general: chest pain.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Tadachem 20 contraindications in the following cases:

Combined with organic nitrate or nitrite, continuous and/or non -continuous.

Hypersensitivity to Tadalafil or any ingredients of the drug.

Not used for male patients with cardiovascular disease but is advised to avoid sex.

Patients with vision loss one eye due to anemia anemia before not caused by arteritis.

Patients with uncontrolled arrhythmia, hypotension (

Patients with stroke within 6 months ago.

Patients with myocardial infarction within 90 days ago.

Patients with unstable angina or angina occur during sex.

Patients with heart failure group 2 or higher within 6 months.

Caution when using

cardiovascular

Sexual activity is related to cardiovascular risk. Therefore, it is advisable to assess the patient's cardiovascular condition before starting treatment with Tadalafil. The serious effects related to Tadalafil have been reported including myocardial infarction, sudden cardiac arrest, stroke, chest pain, suspense and fast circuit.

Do not treat erectile dysfunction with Tadalafil in patients who are recommended not to be sexually active because of cardiovascular condition. Particularly interested in the risk of hypotension or vasodilation in patients with left ventricular congestion (aortic stenosis, narrowing under the aorta due to spontaneous hypertrophy) or seriously reducing the ability to automatically control blood pressure.

Smart

Do not use Tadalafil in patients with genetic degenerative retinal disorders, including pigmentitis.

urinary - genital

Be cautious when taking the drug in patients with penile anatomical deformations (angular folding penis, caves fiber, peyronie disease) and diseases that can cause penile pain (sickle cell anemia, myeloid pain, leukemia).

Do not simultaneously coordinate Tadalafil with other drugs to treat erectile dysfunction because of its safety and effectiveness when combining these drugs has not been studied.

The use of Tadalafil for people under 18 has not been evaluated. Therefore, do not use tadalafil for children or babies.

The ability to drive and operate machinery

There has been no research on affecting the ability to drive and operate machinery. However, patients should be warned about the use of Tadalafil before driving and operating machinery.

Pregnancy

Tadachem 20 drugs are not for pregnant women.

Breastfeeding period

Tadachem 20 drugs are not for breastfeeding women.

Drug interaction

Organic nitrates and nitric derivative: increase the effect of lowering blood pressure, including inhaled nitrite. Contraindicated when coordinating Tadalafil with these drugs.

Medicines affect the liver microsom enzyme:

Combined with strong CYP3A4 inhibitors (ketoconazole, HIV protease inhibitors, Non -inhibitors - Nucleosidal transcriptase): Tadalafil's increase in AUC.

Combined with HIV Protease inhibitors (Amprenavir, Atazanavir, Fosamprenavir, Indinavir, Lopinavir in collaboration with Ritonavir, Nelfinavir, Ritonavir, Saquinavir, Tipranavir in combination with Ritonavir Low Dosage) or Non -Nicotide Inhibitors: In plasma, the level of absorption and semi -waste time of Tadalafil.

Combined with rifampin, CYP3A4 touch substance: reduces tadalafil concentration.

Hypertension drugs: The risk of hypotension when combined simultaneously with hypertension (Doxazosin, Angiotensin II receptor blockers). Be careful when used simultaneously with PDE Typ 5 inhibitors and Alpha receptor blockers, as both are vasodilators. Combining Tadalafil with Metoprolol, Enalapril, Amlodipin or Bendrofluazid reduces blood pressure.

Alcohol: Do not use excessive alcohol (such as 5 glasses of alcohol or 5 sips of whiskey) when using Tadalafil. There are no clinical significance effects on the pharmacokinetics of Tadalafil or alcohol.

Theophylllin: Potential pharmaceutical interaction (the mild increase of theophylin increases the heart rate).

Antacuetical drugs: Potential pharmacokinetic interactions (reducing the speed but the absorption level of tadalafl does not decrease) when used simultaneously with Magnesi hydroxyd/aluminum hydroxyd/aluminum drugs.

Storage

Store in a cool dry place, under 30 ° C. Avoid light.

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