Tadalafil 20mg Cophavina medicine for erectile dysfunction (1 blister x 4 tablets)

Dosage form Box of 1 blister x 4 tablets
Specifications Tadalafil

Ingredient

Composition information	Content
Tadalafil	20mg

Uses

Indications

Tadalafil 20mg drugs are indicated in the following cases:

Treatment of erectile dysfunction in adult men, it is necessary to have sexual stimulation activities to be effective.

Pharmacy

The drug is indicated in the treatment of erectile dysfunction.

Tadalafil is a selective inhibitor, with restoration of guanosine monophosphate (CGMP) - especially on enamel phosphodiesterase tube 5 (PDE -5).

When stimulating sex leads to local oxide nitric release, the PDE-5 inhibitor of Tadalafil increases the CGMP level in the cave. This leads to smooth muscle relaxation and increases blood flow into the penis tissue, thereby causing penis. When there is no sexual stimulation, Tadalafil has no effect.

Dynamic pharmacy

Tadalafil is quickly absorbed after drinking, the peak concentration of plasma is about 2 hours. The absorption of the drug is not affected by food and the time of using the drug.

Tadalafil is widely distributed throughout the tissues and about 94% linked to plasma proteins, metabolized in the liver mainly by isenzyme cytochrome P450 CYP3A4. The main metabolite is methylcatechol Glucuronide does not work. Tadalafil's average sale time is about 17.5 hours.

Tadalafil is excreted mainly in metabolites, in stool (61% of the dose) and urine (36% dose). The elimination is reduced in the elderly and patients with renal failure.

Before taking Tadalafil 20mg Cophavina medicine for erectile dysfunction (1 blister x 4 tablets)

How to use

Tadalafil 20mg oral orally and regardless of the meal.

Dosage

The usual dose is 10mg, at least 30 minutes before sex.

Dosage daily may increase to 20mg or decrease to 5mg as needed. The effect of the drug can last up to 36 hours after drinking. Only once a day and should not be used continuously daily because there is no full data of the safety of the drug when used for long term.

No need to adjust the dose in the elderly.

Hepatic failure: In patients with mild to medium and mild liver failure, the maximum dose must not exceed 10 mg once a day. Do not use Tadalafil for patients with severe liver failure.

Renal failure: Moderate renal failure (creatinine clearance from 31 - 50 ml/minute), should start at a dose of 5mg not exceeding once a day, maximum dose not exceeding 10mg/time every 48 hours. In patients with severe renal impairment (creatinine clearance below 30 ml/ min) or blood decay, the maximum dose must not exceed 5mg/ time every 72 hours.

Patients have stabilized with Alpha receptor blockers, which should be used with Tadalafil at a starting dose of 5 mg.

Patients use strong Cytochrom P450 ISOENZYM CYP3A4, should not use more than 10mg/time every 72 hours.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? The side effects occur similarly to the lower doses of the dose. In case of overdose, the standard support measures should be taken as required.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Tadalafil 20mg, you may experience unwanted effects (ADR).

Like Sildenafil, most of the unwanted effects are reported as headaches, flushing, indigestion. Can cause visual disorders, dizziness, stuffy nose. Visual disorders may occur infrequently with Tadalafil rather than with Sildenafil.

Other undesirable effects have been reported include: diarrhea, vomiting, swelling of the eyelids, pain and redness, nosebleeds, muscle pain, back pain, skin rash, urinary tract infections, fainting, hemorrhage of cerebrovascular and transient ischemic.

may also have penis pain.

may require a decrease in the dose for liver and renal failure patients.

Notify the doctor with unwanted effects when taking the drug.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Tadalafil 20mg contraindications in the following cases:

Hypersensitivity to one of the ingredients of the drug.

Concomitance Tadalafil with organic nitrates in any form.

Male patients who have sex should avoid cardiovascular disease.

Patients with new myocardial infarction within 90 days.

Patients with unstable angina or angina occur during intercourse.

Heart failure is worse within 6 months.

Patients with uncontrolled arrhythmia, low blood pressure (

Patients with stroke within 6 months.

Precautions when using

Patients with severe kidney failure or severe liver failure.

Patients with diseases that can cause penis pain (such as sickle cell anemia, multiple marrow tumors, leukemia), or in patients with penis anatomy (such as an angle folding penis, cave fibroid or peyronie disease).

The ability to drive and operate machinery

Unsoniance.

Pregnancy

Not used.

Breastfeeding period

Not used.

Drug interaction

organic nitrate and nitric derivative: increase the risk of hypotension, even when using inhaled nitrate. Contraindicated when coordinating Tadalafil with these drugs.

Medicines affect the liver microsom enzyme: combined with strong CYP3A4 inhibitors (ketoconazol, HIV protease inhibitors, nucleotid -free copy inhibitors): Tadalafil's AUC increase.

Combined with HIV Protease inhibitors (Amprenavir, Atazanavir, Fosamprenavir, Indinavir, Lopinavir in collaboration with Ritonavir, Nelfinavir, Ritonavir, Saquinavir, Tipranavir in combination with Ritonavir Low -dose) or Nuoceotide inferior enamel inhibitors: collection and semi -cancellation time of Tadalafil.

Combining rifampicin, CYP3A4 touch substance: reducing tadalafil concentration.

High blood pressure treatment: The risk of hypotension when combined simultaneously with high blood pressure medications (Doxazosin, Angiotensin II receptor blockers).

Be cautious when used simultaneously with PDE inhibitors 5 and Alpha receptor blockers, as well as other vasodilators. Combining Tadalafil with Metoprolol, Enalapril, Amlodipin or Bendrofluazid reduces blood pressure. Hypotension also occurs when combining Tadalafil and Alpha receptor blockers.

Storage

Leave a dry place, the temperature does not exceed 30 ° C, avoiding light.

Expiry date: 36 months, from the date of production.

Read the user manual carefully before use.

If you need more information, please consult a doctor.

This drug is only used as prescribed by a physician.

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