Tadaritin 5mg Tada Pharma reduces allergic rhinitis, urticaria (3 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 3 blisters x 10 tablets
Ingredient Desloratadine
Indication Allergic rhinitis, itching, stuffy nose
Contraindication Hres, atopic dermatitis, contact dermatitis

Ingredient

Composition information	Content
Desloratadine	5mg

Uses

indications

The drug is indicated for adults and adolescents (> 12 years old) to reduce symptoms related to diseases:

Seasonal or chronic allergic rhinitis. Desloratadin antihistamine instant and effective long -term effect, has the effect of selecting the histamine - H1 receptor receptor in the peripheral. After drinking, desloratadin selectively inhibits the H1 receptor in the peripheral because it does not penetrate the central nervous system.

Desloratadin has an anti-allergy effect due to the inhibition of inflammatory cytokines such as IL-4, IL-6, IL-8, IL-13 from Mast cells (macrophages) and BaSophils (alkaline leukemia) in the human body as well as inhibiting the revealing of p-selectin-adhesive molecules in endothicial cells.

Desloratadin takes effect that loses symptoms such as sneezing, nose and itching, congestion/congestion, including itchy eyes, watery eyes, red eyes and itchy palate in patients with allergic rhinitis. Desloratadin effectively control these symptoms for 24 hours.

Desloratadin effectively reduces symptoms for urticaria in addition to spontaneous chronic urticaria. Desloratadin is effective in reducing itching and reducing the size and number of rashes.

Pharmacokinetics

absorption

Can find desloratadine concentrations in plasma after taken for 30 minutes.

Desloratadin absorbs well, reaching a plasma peak concentration after about 3 hours. The bioavailability of desloratadine is proportional to the dosage in the range of 5 - 20 mg.

Food (Lipid -rich breakfast, energy -rich, grapefruit juice) does not affect the pharmacokinetics of Desloratadin.

Distribution

Desloratadin is moderately attached to plasma proteins (83 - 87%). Clinically, it has not been noticed the accumulation of drugs after taking the only dose 5 - 20 mg daily for 14 days.

Metabolism

The enzymes are responsible for the metabolism of the desloratadin have not been determined, so some interactions with other drugs can be completely excluded. Desloratadin does not inhibit CYP34A In Vivo, and in-Vitro studies have shown that Desloratadin does not inhibit CYP2D6 and nor is the substrate or inhibitor of p-glycoprotein.

Elimination

The final waste time is about 27 hours. The accumulation of desloratadin is suitable for the sale time (about 27 hours) and with a single -dose frequency of the day.

Before taking Tadaritin 5mg Tada Pharma reduces allergic rhinitis, urticaria (3 blisters x 10 tablets)

How to use

oral medication. Use as directed by the treating doctor.

Dosage

Adults, children over 12 years old and the elderly

The usual dose is 5 mg Desloratadin (1 tablet), the only dose of the day.

Children under 12 years old

There is no research data to determine safety and impact on children under 12 years old, so they are not used for children under 12 years old.

Adults with impaired liver and kidney function

The starting dose is 5 mg, used by day, or based on the pharmacokinetics of the drug. There is no complete research on safety when taking drugs for children with liver or kidney failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Recommendation for symptomatic treatment and supportive treatment.

Based on multi -dose clinical trials in adults and young people with recommended dose to 45 mg Desloratadin (9 times the usual dosage), does not observe the clinical effects related.

Desloratadin is not excreted by dialysis; It is unclear whether it is excreted by the peritoneal dung.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Common, ADR> 1/100

Body: Fatigue.

Uncommon, 1/1000

Digestive system: dry mouth.

Nervous system: headache.

Not determined frequency

Nervous system: mental disorders, hallucinations, nervous system disorders, dizziness, sleep, insomnia, Increased mental activity, convulsions.

Cardiovascular system: heart disorders, chest drums, tachycardia.

Digestive system: intestinal disorders, abdominal pain, nausea, vomiting, indigestion, diarrhea.

Liver system: liver disorders, hepatic enzyme hyperplation, bilirubin, hepatitis.

musculoskeletal system: bone disorders and connective tissue, muscle pain. Systemic: Systemic disorders.

The immune system: Hypersensitivity reaction (such as anaphylaxis, angioedema, shortness of breath, itching, rash, urticaria).

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

contraindicated

tadaritin contraindicated for the following cases:

Hypersensitivity to the active ingredient, any ingredients of the drug or Loratadin.

Children under 12 years old.

Be cautious when using

Effective and safety of desloratadin for children under 12 years of age has not been set.

Be cautious when using desloratadine in case of severe renal failure.

Patients with genetic problems of galactose absorption, Lapp Lactase deficiency or galactose are not absorbed by this drug.

The ability to drive and operate machinery

In clinical trials to test driving capabilities, no decline appears in patients using the drug.

However, patients need to be notified that some cases of drowsiness are drowsy after taking the drug, this may affect the ability to drive or operate machinery. Therefore, patients should be cautious if taking the drug while driving or operating machinery.

Pregnancy

Desloratadin does not affect the development of embryos in animal tests. The safety of using this drug during pregnancy has not been confirmed. Therefore, it is not recommended to use desloratadin during pregnancy.

breastfeeding period

Women who are breastfeeding should not use desloratadin due to desloratadin secreted into breast milk.

Drug interaction

does not observe clinical significance when using the Desloratadin tablet simultaneously with erythromycin or ketoconazole in clinical trials.

In clinical pharmacological testing, desloratadin is drinking with alcohol does not reduce the risk of side effects due to alcohol.

Storage

Storage below 30 ° C. Avoid light.

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