Tamiflu Roche Treatment of influenza (1 blister x 10 tablets)

Dosage form Box of 10 tablets
Specifications Oseltamivir

Ingredient

Composition information	Content
Oseltamivir	75mg

Uses

indications

Tamiflu 75 mg is indicated in the following cases:

Treatment of influenza: Tamiflu is indicated to treat influenza in adults and children including newly sufficient newborn babies with typical symptoms of influenza during the time when the flu virus is circulating in the community. Effective when starting treatment within 2 days after the first symptom of influenza. Influenza.

Note: Currently, the drug has not been licensed to treat Covid-19 due to the new Corona virus strain (SARS-COV-2).

Pharmacokology

oseltamivir phosphate is the precursor of oseltamivir carboxylate (OC), a selective inhibitor and too effective Neuraminidase of influenza A and B. This enamel plays an important role in helping the virus to penetrate the healthy cells, which helps release new virus parts formed from the cells, and thus the process of the cells. Virus infection.

oseltamivir carboxylate inhibits neuraminidase of influenza virus both type A and B. OC both inhibit the infection and copy of the In-Vitro influenza virus, while inhibiting the copy and pathogenicity of the In-Vivo influenza virus.

Dynamic pharmacokinetics

absorption: oseltamivir is quickly absorbed in the digestive tract after taken and a large part of the drug is converted into active substances, mainly thanks to the esterase enzyme in the liver.

Distribution: The average distribution volume (VSS) of metabolites has a activity of about 23 liters in humans.

Metabolism: A large amount of oseltamivir phosphate is converted into an active metabolic substance thanks to the esterase enzyme, which is localized mainly in the liver. Both oseltamivir and active metabolites are not the substrate or inhibitors of the Cytochrome P450.

Elimination: OSELTAMIVIR after absorption is eliminated mostly (> 90%) by converting into activated metabolites. This substance is not further metabolized but eliminated through the urine.

Before taking Tamiflu Roche Treatment of influenza (1 blister x 10 tablets)

How to use

The drug is used by oral, with or without food.

Dosage

Dosage in case of influenza treatment

Treatment within the first 2 days of the flu when there are symptoms of fever, runny nose, headache.

Adults, teenagers 13 years and older: Dosage recommended 75 mg 2 times/day, drink for 5 days. In case of failure to swallow capsules, it is possible to use the illusory drug in the same dosage.

Children: If children weigh over 40 kg, swallowing capsules can also be treated at a dose of 75 mg x 2 times/day or 1 tablet of 30 mg plus 45 mg tablets 2 times/day.

Dosage in children may vary depending on weight, age and condition.

Children under 1 year of the recommended dose is 3mg/kg x 2 times/day, used for 5 days. This recommended dose does not apply to infants with weeks of weeks of 36 weeks of conception.

Dosage in case of influenza prevention

Adults and teenagers 13 years and older: Prevention in case of being exposed to the influenza -infected person may have or have no symptoms and use the drug within 2 days after contact with the source.

Dosage recommended 75 mg once a day, drink at least 10 days.

The recommended dose for the prevention of flu during the community is 75 mg once a day.

Children from 1 year of age: If a child weighs over 40 kg, can swallow capsules can also be treated at a dose of 75 mg once a day or 1 tablet 30 mg plus 45 mg tablet once a day.

Patients with immunodeficiency: The prevention of seasonal influenza for patients with immunodeficiency from 1 year of age is recommended for 12 weeks. No dose adjustment.

Elderly patients: No dose adjustment for the elderly when treated or prevention of influenza.

Patients with liver failure: No dose adjustment for patients with mild or moderate liver dysfunction when treated or prevented from the flu.

Patients with renal failure:

No dose adjustment for patients with creatinine clearance is over 60 ml/min.

Creatinine clearance from 30 - 60 ml/min, reduce the dose of Tamiflu to 30mg x 2 times/day, drink for 5 days. In the prevention of influenza, only 30 mg once a day.

Creatinine clearance from 10 - 30 ml/minute, reducing the dose to 30mg once a day, for 5 days. In case of prevention of flu, the patient takes the dose of 30mg daily.

Patients are periodic hemolysis periodically, if the flu symptoms occur in a period of 48 hours between two hemolysis, the starting dose of 30 mg may start at the beginning of the hemolysis.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Tamiflu 75 mg, you may experience unwanted effects (ADR).

adults and teenagers

Common, ADR> 1/100:

Neurology: headache.

Digestive: nausea.

In addition, patients may experience some other unwanted effects:

Infections and KST infections: bronchitis, herpes Simplex infection, nasopharyngitis, upper respiratory infection, sinusitis.

Neurological: Insomnia.

Respiratory: cough, sore throat, runny nose.

Children

Common, ADR> 1/100:

Respiratory: cough, stuffy nose.

Digestive: nausea.

In addition, children may experience some other unwanted effects including:

Infection and KST infection: Middle otitis.

Neurology: headache.

Eyes: conjunctivitis (red eyes, eye -catching eyes, eye pain).

Respiratory: runny nose.

Gastrointestinal: abdominal pain, digestive disorders, nausea.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Tamiflu 75 mg is contraindicated in cases of hypersensitivity to oseltamivir phosphate with any ingredients of the drug.

Be cautious when used

oscingiVir is only effective for the disease caused by the flu virus and has not shown the effect of oseltamivir in any disease caused by agents other than the flu virus.

Tamiflu does not replace the flu vaccine. The use of Tamiflu does not affect the personal health check for annual influenza vaccination.

The prescription should be included in the new beliefs currently available on the sensitive samples with the virus's OSeltamivir before deciding whether to use Tamiflu or not.

There are cases of serious anaphylaxis and skin reactions including poisoned epidermal necrosis, Stevens-Johnson syndrome, and morphological rash when using Tamiflu. Tamiflu treatment should be stopped and replaced with appropriate therapies if occurring or suspected allergic reactions on the skin.

Monitoring if there are symptoms such as convulsions, otitis media or mental events like delusion mainly occurs in children and young people.

Some serious infections may start with symptoms of flu or may appear with the flu or appear due to complications of influenza infection.

The ability to drive and operate machinery

The drug does not cause any side effects on the ability to drive and operate machinery.

Pregnancy

The risk of pregnancy group b.

Pregnant women can use Tamiflu, after considering the safety information available, the ability to cause the disease of the current virus strains and the condition of the pregnant woman.

The period of breastfeeding

The drug is excreted in low concentrations, so it is necessary to consider the disease of the current influenza virus and the health status of nursing mothers to consider using oseltamivir.

Interactive drug

Drugs show that there is no possibility of drug interactions that are clinically significant.

Storage

Store in a dry place, temperatures below 30 ºC.

Roche is the world's leading pharmaceutical group based in Switzerland, operating in two areas mainly providing equipment, diagnostic and research and production tests and production.Roche's mission is to focus on the development of drugs and diagnostics in order to address medical needs that have not been met through science excellence - from early detection and disease prevention to diagnosis, treatment and treatment monitoring.

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