Tamunix 300mg Incepta treatment of osteoarthritis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Etodolac

Ingredient

Composition information	Content
Etodolac	300mg

Uses

indications

Tamunix 300 medicine is indicated for use in the following cases: Treatment of inflammation, pain caused by arthritis, osteoarthritis, acute and chronic rheumatoid arthritis.

Pharmacokic

Etodolac is an non -steroid anti -inflammatory drug (NSAID) that inhibits anti -inflammatory, analgesic and antipyretic. Etodolac's mechanism of action is like other anti -inflammatory drugs, related to Prostaglandin synthesis.

Dynamic pharmacokinetics

Etodolac are well tolerated and 100% bioavailability when taking 200 mg of Etodolac tablets compared to 80% Etodolac solution. Etodolac does not metabolize at the first stage by oral. Food does not affect the absorption of Etodolac but reduces the peak concentration to nearly 1.5 hours and increases the peak concentration time to 1.4 - 3.8 hours.

The average distribution concentration of Etodolac is approximately 390 ml/kg. More than 90% of Etodolac binds to plasma proteins, mainly albumin.

Etodolac's medium -sized oral clearance is 49 (± 16) ml/kg.

Before taking Tamunix 300mg Incepta treatment of osteoarthritis (3 blisters x 10 tablets)

How to use

oral medication.

Dosage

Adults

The usual dose for adults: 600 mg/day, divided into 1-2 times. Dosage should be adjusted depending on the response of each patient.

Chronic therapy

The common response is monitored within 2 weeks. After the results, it is necessary to review and adjust the dose for the patient.

children and young people

Safety and effectiveness in children under 18 years of age have not been evaluated.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Causing vomiting or using activated carbon (60 - 100 g in adults and 1 - 2 g/kg in children), and/or washing the intestine for 4 hours after overdose. Do not use diuretics, alkaline, hemorrhage due to Etodolac has high cohesion with plasma proteins.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Tamunix 300, you may experience unwanted effects (ADR).

Unknown frequency, ADR

Gastrointestinal tract: abdominal pain, constipation, diarrhea, indigestion, flatulence, bleeding, heartburn, nausea, stomach ulcers, vomiting.

Nervous system: weakness/discomfort, dizziness, depression, anxiety. Skin: itching, rashes ...

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Tamunix 300 drug is contraindicated in the following cases:

Patients with hypersensitivity to Etodolac or any ingredient of the drug.

Patients with gastrointestinal ulcers or acute gastrointestinal bleeding.

Patients with asthma, urticaria, or allergies to aspirin or other nonsteroidal anti -inflammatory drugs (NSAID).

Pregnant or breastfeeding women. Children under 18 years old.

Etodolac is not used to treat the pain around the incision during coronary surgery.

Be cautious when used

should be cautious when prescribing NSAID anti -inflammatory drugs in patients with a history of ulcerative or stomach bleeding. In order to minimize the potential risk for adverse response in the stomach, the lowest effective dose should be used in the lowest possible time.

Etodolac can lead to new hypertension or cause hypertension to worsen and have the potential to increase the risk of cardiovascular diseases. Etodolac caution should be used in patients with hypertension.

Hemorrhage and edema: Water and edema have been observed in some patients using NSAIDs. Therefore, caution should be used for Etodolac in these patients.

Etodolac cannot replace corticosteroids or supplement corticosteroids in treatment. Sudden corticosteroid treatment will make the disease worse.

Etodolac's pharmacological effect is to reduce fever and inflammation that can reduce the use of diagnostic signs in finding complications of non -inflammatory or painful diseases.

Patients with signs and symptoms of liver dysfunction should check liver function during treatment with Etodolac. If signs and symptoms show that liver disease progresses, or if there are manifestations such as eosin hypernagus, rashes ... need to stop treating with Etodolac.

The ability to drive and operate machinery

without information.

Pregnancy

Etodolac has not been fully studied in pregnant women. Like other NSAID anti -inflammatory drugs, do not use drugs for pregnant women.

Lactation period

Due to the possible effects of NSAID anti -inflammatory drugs for breastfeeding babies, mothers do not use Etodolac while breastfeeding or stop breastfeeding while taking the drug.

Drug interaction

antacid

There is no prolonged manifestation of Etodolac when taken with antacid. However, Antacid may increase the peak concentration of up to 15-20%, but does not affect the time to reach the peak concentration.

aspirin

The cohesion is impaired when oral in combination with Etodolac with aspirin, although the freezer of free Etodolac is not changed. The clinical signs have not been seen. However, this combination should not be used by the risk of increasing unwanted effects.

cyclosporin, digoxin, methotrexate

Like other NSAIDs, Etodolac can change the elimination that leads to increased plasma concentrations of cyclosporin, digoxin, methotrexate and increased toxicity. Increased toxicity for kidneys due to cyclosporin. Patients, especially those with renal function, when using these drugs or Etodolac or NSAID, need to be monitored the progression of the special toxicity of the drug.

Diuretics

There is no pharmacological interaction when used in combination with Etodolac with Furosemid or hydrochlorothiazid. However, clinical studies show that Etodolac can reduce the diuretic effect of Furosemid and Thiazid.

phenylbutazon

Phenylbutazon increases the free division of Etodolac to about 80%. Although there are no In-Vitro studies to see if the Etodolac clearance has been changed by a combination of phenylbutazon and Etodolac, it should not be used in combination with these two drugs.

Storage

Store in a dry place, temperature below 30 ° C.

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