Tanametrol 4mg tablets to male anti -inflammatory and treat rheumatoid arthritis, lupus erythematosus (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Methylprednisolone

Ingredient

Composition information	Content
Methylprednisolone	4mg

Uses

indications

tanametrol drugs are indicated in nonspecific therapy that requires anti -inflammatory and immunosuppressive effects of glucocorticoid for:

rheumatoid arthritis, systemic lupus system, some vasculitis form; Pacific artery and inflammation around the artery, sarcoid disease, bronchial asthma, chronic ulcerative, hemolytic anemia, granulocytopenia, and severe allergens including anaphylaxis; In the treatment of cancer, such as acute Leukemia disease, lymphoma, breast cancer and prostate cancer.

ATC code: H02AB04.

methylprednisolon is a glucocorticoid, derivative 6 - alpha - methyl of prednisolon, has anti -inflammatory, anti -allergic and immunosuppressive effects. Due to methylation Prednisolon, corticosteroids metabolize salt have been excluded, so there is very little risk of keeping Na+, and causing edema. The anti -inflammatory effect of methylprednisolon increases by 20% compared to the effect of Prednisolon; 4 mg methylprednisolon is valid as 20mg of hydrocortison.

Dynamic pharmacokinetics

bioavailability is approximately 80%. Plasma concentration reaches a maximum of 1-2 hours after taking the drug. Biological effect time (inhibiting pituitary gland) is about 12 days, can be considered a short effect. Methylprednisolon is metabolized in the liver, like metabolism of hydrocortison, and metabolites are excreted through urine. Half life is approximately 3 hours.

Before taking Tanametrol 4mg tablets to male anti -inflammatory and treat rheumatoid arthritis, lupus erythematosus (3 blisters x 10 tablets)

How to use

tanametrol drugs used by oral, should be used with food.

Dosage

Determine the dose for individuals and the type of disease. The starting dose is: 6 - 40 mg of methylprednisolon (1 % - 10 capsules) per day. The necessary dose to maintain the desired treatment is lower than the dose needed to achieve the initial effect, and must determine the lowest dose that can be achieved by the need for gradually reducing the dose step by step until the signs or symptoms increase.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

When using too high doses for a long time, increase adrenal gland energy and inhibit the adrenal glands may occur. In these cases, it is necessary to consider to make the right decision to suspend or stop using Glucocorticoid.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

The most common effects occur most when using methylprednisolon is high and long -term. Methylprednisolon inhibits prostaglandin synthesis and thus losing the effect of prostaglandin on the digestive tract, including inhibiting gastric acid secretion and protecting the stomach lining. Many undesirable effects are related to this effect of glucocorticoid.

Common

Insomnia, nervousness is easily agitated.

Increased appetite, indigestion.

Dizziness, convulsions, mental disorders, fake tumors in the brain, headache, mood change, delirium, hallucinations, refreshment.

edema, hypertension. Sodium and water, hyperglycemia.

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Tanametrol drugs contraindicated in the following cases:

Hypersensitivity to methylprednisolon or any ingredients of the drug.

Caution when using

Caution in people with osteoporosis, new blood vessel connection, magic disorders, stomach ulcers, duodenum ulcers, diabetes, hypertension, heart failure and growing children, liver failure, kidney failure, thyroid disease, cataract.

Due to the risk of unwanted effects, caution must be used with all body corticosteroids for the elderly, with the lowest doses and in the shortest possible time.

Acute adrenal insufficiency may occur when stopping the drug suddenly after a long time of treatment or when stressed.

When using high doses, it can affect the effect of vaccinations.

Lactose excipient warning: The drug contains lactose, so it is not used for patients with rare genetic disorders in galactose intolerance, lactase lactase deficiency or glucose - galactose absorption disorders.

Use drugs for women during pregnancy and lactation

pregnancy:

For extension of body corticosteroids for mothers can lead to mitigation of the baby's weight. In general, using corticosteroids in pregnant women requires consideration of benefits that can be achieved compared to the risks that may occur with mother and child.

breastfeeding period:

Not contraindicated corticosteroids for nursing mothers.

The effect of the drug on the ability to drive and operate machinery

The drug can cause dizziness, so it is cautious when used for drivers and machinery operators.

Drug interaction

methylprednisolon is a cytochrom P450 enzyme induction, and is the substrate of the P450 3A enzyme, so this drug affects the metabolism of ciclosporin, erythromycin, phenobarbital, phenytoin, carbamazepin, ketoconol, ketoconol, ketoconol, ketoconol, ketoconol, ketoconol, ketoconol, ketocon, ketocmazepin Rifampicin.

Phenytoin, Phenobarbital, Rifampin and diuretics decreased potassium can reduce the effectiveness of methylprednisolon.

methylprednisolon may cause hyperlemor of blood glucose, so higher insulin dose is needed.

Cavalry

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

Other drugs

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