Targinos 400 Mebiphar Treatment maintenance blood ammonia (12 blisters x 5 tablets)

Dosage form Box of 12 blisters x 5 tablets
Specifications Arginine

Ingredient

Composition information	Content
Arginine	400mg

Uses

Indications

Targinos 400 drugs are indicated in the following cases:

The treatment of blood ammonia in patients with carbamyl phosphate deficiency synthetase, lack of ornithin carbamyl transferase. Improve training ability in people with stable cardiovascular disease.

Nutrition supplements for people with urea cycle disorders such as hyper ammonia tube I and II, blood citrulin, arguosuccinicuria and N-acetyl glutamate synthetase. For patients who lack enzymes: N-acetylglutamat synthase (NAGS), Carbamyl Phosphate Synthetase (CPS), Ornithin transcarbamylase (OTC), ArgininoSuccinat Synthetase (ASSS), or ArginininoSuccinat Lyase (ASL).

Use Arginin hydrochloride for patients with disorders as above to restore arginin concentrations in the blood and help prevent protein catabolism. The intermediate products of the urea cycle are less toxic and easily eliminate through urine than ammonia and create other paths for excess nitrogen elimination.

arginine increases blood glucose levels. This effect may be direct effect; The amount of glucose released from the liver is directly associated with the amount of amino acids absorbed. The Glycogen prize and the new glucose creation may also be the intermediary of the arginin process that stimulates Glucagon release.

pharmacokinetic

absorption

Arginin hydrochloride absorbs well through the gastrointestinal tract. The peak concentration in plasma is achieved after about 2 hours. Absolute 70%bioavailability. Arginin hydrochloride is combined with many biochemical reaction processes.

Metabolism

Strong metabolic drugs in the liver, forming ornithin and urea through the hydrogen subdivision of Guanidine under the catalyst of arginase.

Elimination

arginin is filtered in the renal tubules and is absorbed almost completely in the renal tubules. Half lifetime elimination: 1.2 - 2 hours.

Before taking Targinos 400 Mebiphar Treatment maintenance blood ammonia (12 blisters x 5 tablets)

How to use

"Targinos 400" drug used oral. Take medicine with food.

Dosage

Maintain blood ammonia in patients with carbamyl phosphate deficiency synthetase, lack of ornithin carbamyl transferase.

Oral

infant: 100mg/kg per day, divide 3-4 times. Oral

Infants: 100 - 175mg/ kg/ time, use 3-4 times daily with food, adjust the dose according to the response.

Treatment to support indigestion disorders:

Adults: Take 3 - 6g/ day.

Support treatment to improve exercise ability in people with stable cardiovascular disease.

Adults: Take 6 - 21g/ day, each use no more than 8g.

Nutrition supplements for people with urea cycle disorders such as hyper ammonia tube I and II, hyperculose blood, arguoSuccinicurin and N-acetyl glutamate synthetase:

Adults: Take 3 - 20g/day depending on the condition.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Acid infection will be rehabilitated and the basic deficiency will return to normal after completing the transmission. If the situation is prolonged, it is advisable to redefine the shortage and correct it because the dose calculated by the alkaline agent.

There are reports on overdose in children. Must be very careful when intravenously arginin hydrochloride solution for children. Overdeeity of this drug in children can lead to acidic metabolism of kidney, cerebral edema or may die. An appropriate antihistamine should be available for allergic reactions.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Targinos 400, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Central nervous system: Numbness, headache;

digestive: nausea, vomiting;

Endocrine - Metabolism: increase body temperature;

Other: flushed, stimulating local vein.

Rare, ADR

Skin: edema, red, pain;

Hematology: reducing platelets; immune: Anaphylactic reaction;

Unknown frequency

Cardiovascular: Reducing blood pressure, venous inflammation.

Respiratory: Heavy cough (when arguin steam for children with cystic fibrosis); Increase the breath of oxyd nitric and reduce FEV1 (exertion volume in 1 minute) in asthma.

digestive: abdominal spasms and abdominal distention in patients with cystic fibrosis.

Endocrine - Metabolism: Causes growth of growth hormones, insulin, glucagon, prolactin. Hypotension in people with liver, kidney, diabetes. Reducing blood phosphorus in diabetes patients.

urinary tract: increased blood urea nitrogen and serum creatinine.

Instructions on how to handle ADR

allergic reactions, erythema and swelling in the hands and face decreased rapidly after stopping the drug and using diphehydramin.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Targinos 400 drugs are contraindicated in the following cases:

Patients with hypersensitivity to any ingredients of the drug.

Patients with atopic allergies.

Patients with Urian cycle disorders due to Arginase deficiency. Hyperiac hyperactive blood ammonia caused by organic acid infections in the blood.

Be cautious when using

Do not use Arginin hydrochloride for patients with atopic allergies. Antihistamine drugs are used if allergic reactions occur.

Arginin hydrochloride causes hyperkalemia to threaten life for patients with renal impairment because the excretion of potassium decreases in these patients. Arginin should be used to be cautious for patients with kidney or urinary disease.

For acute hypercemolic hyperactemia, high doses of arginin can cause acidic metabolic acid to hypertension, so chloride and bicarbonate levels need to be monitored in plasma and bicarbonate levels and can simultaneously use a suitable amount of bicarbonate. Because arginine contains high levels of nitrogen that can be metabolized, before using the drug, it must be a temporary effect on the kidneys of the high amount of nitrogen.

Do not use Arginin for patients after myocardial infarction.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

There is no complete and well -verified research on the use of arginin in pregnant women, so they do not use this drug for women during pregnancy.

Breastfeeding period

It is unknown whether the arginin is secreted in a significant amount in human milk or not. It is necessary to consider the benefits of treatment with drugs and risks for children to decide the use of drugs and stop breastfeeding.

Drug interaction

Oral avoidance drugs combined with estrogen and progestogen may increase the response of growth hormones and reduce the response of glucagon and insulin with arginine. Insulin concentration in plasma after arginin stimulation may be increased by diurotic thiazid, xylitol and aminophylin diuretic. The following two drugs also reduce the response of glucagon with arginine.

For a long time, SulfonyLure, oral diabetes, can prevent glucagon response in plasma with arginin.

Phenytoin reduces insulin response in plasma with arginine, when patients do not tolerate glucose intolerant to glucose.

Hypered hyperkalemia occurs after arginin therapy for metabolic alkaline infection in several patients with severe liver disease that has just been used Spironolacton.

Patients taking diuretics to reduce potassium consumption are at high risk of hyperkalemia caused by arginine, and thus avoid combining these drugs.

Storage

Keep in closed packaging, cool dry places, avoid light, temperatures below 30 ° C.

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