Tatanol Codeine supports the treatment of moderate and severe pain (20 blisters x 4 tablets)

Dosage form Box of 20 blisters x 4 tablets
Specifications Acetaminophen, codeine

Ingredient

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Composition information	Content
Acetaminophen	500mg
Codeine	30mg

Uses

Indications

Tatanol Codeine drugs are indicated in the following cases: Reduce pain in cases of lumbar pain, headache (in severe cases), nerve pain, body pain, muscle pain.

Pharmacokology

Tatanol Codeine is a combination of pain relief, antipyretic effect of acetaminophen mainly on peripheral and strong pain relief effect of Codeine in the central nervous system, so Tatanol Codeine is highly effective in the treatment of pain even if cases do not respond to peripheral pain.

Acetaminophen's pain relief mechanism has not been fully known, possibly due to prostaglandin synthesis in the central nervous system, and the peripheral effect is caused by the generation of pain. The peripheral effect may also be due to prostaglandin synthesis or synthetic inhibition or inhibition of impacts of receptors sensitive to mechanical pain, chemical stimulation.

A reduction mechanism: Prostaglandin synthesis in inhibitor in the hill thermostat center causes peripheral vasodilation, the result increases the blood circulation through the skin, increases sweating, and cools down.

Pharmacy code is used in combination with acetaminophen to increase pain.

In addition, Codeine also works directly to the cough center in the brain, which is a cough in the case of dry cough, which causes insomnia.

pharmacokinetic

acetaminophen

Acetaminophen is absorbed quickly and completely when used orally.

Tmax 1 - 3 hours. Extend time for 3-4 hours. The pharmacokinetic parameters in milk when the mother taken the only dose 650mg: Tmax 1 - 2 hours, cmax 10 - 15µg/ml, t1/2 1.35 - 3.5 hours.

Quick distribution to all tissues.

Metabolized by liver microsom enamel. There is a small part of acetaminophen being n-hydroxylated by CYP450 enzyme into a reaction mediator, N-acetyl-benzo-quinoneimin, causing liver cell necrosis.

Elimination through urine is mainly in the form of combined. In adults, 60% of the dose is excreted in the form of glucuronic acid, 30% associated with sulfate, 4% associated with cysteine and mercapturic, about 3% excreted in constant form. In children, the same excretory ratio but in the form of sulfate more, the Glucuronic Complex is less.

codeine

is absorbed quite quickly in the intestine, the maximum concentration is achieved after 60 minutes. T1/2 in plasma in adults about 3 hours.

Metabolvated in the liver and excreted through urine in conjugated with glucuronic acid. This combination has little affinity for the receptors of Opium.

The drug can pass the placenta, less excreted by breast milk when using a single dose.

Before taking Tatanol Codeine supports the treatment of moderate and severe pain (20 blisters x 4 tablets)

How to use

Take oral use.

Dosage

Adults

1 - 2 capsules, 1-3 times/day, depending on the degree of disease, the use should be at least 4 hours apart.

Patients with severe renal failure (creatinine clearance

Tatanol Codeine drugs apart at least 8 hours apart.

Children ≥ 15kg (≥ 3 years)

Dosage of Codeine 3mg/kg/day, divided into 4-6 times. Maximum 1mg/kg/time (6mg/kg/day).

Finished products containing Codeine are sold without a maximum number for 10 days of use.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Acetaminophen

Symptoms: diarrhea, anorexia, nausea, vomiting, pale, abdominal pain, increased sweating, liver poisoning. These symptoms usually appear in the first 24 hours and may still occur after 2-4 days, in severe cases that cause liver cell necrosis, death when overdose from 8-16 hours, can cause kidney necrosis, can bleed.

Treatment

Must be immediately transferred to the hospital, causing vomiting or gastric lavage to eliminate drinking drugs.

Activated carbon (activated carbon can reduce the effectiveness of treatment when taking acetylcysteine to treat overdose acetaminophen).

N-specific antidote N-acetylcystein, the amount of n-acetylcystein is used depending on the amount of acetaminophen used. It is recommended to use N -acetylcystein immediately after overdose of acetaminophen, especially within 10 - 12 hours. Determine the concentration of acetaminophen at the latest after 4 hours.

Display in case after 24 hours of overdose without being treated with N-acetylcystein. Treatment to support total status, maintain water balance, electrolytes.

codeine

High and prolonged doses can cause drug dependence, appearing detox syndrome when the drug is stopped suddenly. Symptoms of overdose may occur in adults such as inhibiting respiratory centers (cyanosis, slow breathing), falling asleep, rash, nausea, itching.

Treatment of respiratory aids. Use naloxon cases of high amount of poisoning.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Tatanol Codeine you may experience unwanted effects (ADR).

At the dose of treatment can cause constipation, drowsiness, dizziness, nausea, vomiting.

Skin rash and other reactions rarely occur, usually erythema or urticaria, sometimes worse and may be accompanied by a fever due to drugs and mucosal lesions. Rarely get skin rash, hypersensitivity reaction.

In a few cases, acetaminophen causes neutropenia, thrombocytopenia and all bloody hemoglobin, kidney toxicity when abuse for a long time.

Instructions on how to handle ADR

When experiencing side effects of Tatanol Codeine, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Tatanol Codeine drugs are contraindicated in the following cases:

Patients with hypersensitivity to drug ingredients.

Patients with respiratory failure, asthma.

Patients with anemia many times or heart, lung, kidney or liver disease.

Patients with glucose deficiency - 6 - Phosphate dehydrogenase.

Children under 18 years of age have just performed tonsils or grated procedures V.A.

Pregnant women.

Precautions when using

Patients with severe renal failure.

Prolonged use can lead to Tatanol Codeine addiction.

Do not drink alcohol, drinks with alcohol, driving and machinery while taking the drug.

For acetaminophen, the doctor needs to warn the patient about the signs of serious skin reactions such as Steven-Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

Due to the risk of respiratory failure, only the medications containing Codeine to relieve acute pain at an average level for children over 12 years old when other painkillers such as acetaminophen and ibuprophen are ineffective.

Codeine should only be used in the lowest doses effectively and in the shortest time.

It is not recommended to use codeine for children who have respiratory problems (for example: shortness of breath or wheezing when sleeping ...).

Be cautious when using Codeine for children under 12 years old (due to the research on the effects of drugs on this object is limited).

Be cautious when using medication for nursing women (because the drug can be excreted in breast milk).

The ability to drive and operate machinery

No driving or operating machinery while using the drug.

Pregnancy

There is no complete study of the use of drugs in pregnant women. Do not use drugs for women who are during pregnancy unless the benefits bring out the risk of harm to the fetus.

Breastfeeding period

because the drug can be excreted in breast milk, cautious when using the drug in nursing women.

Medicinal interaction

Do not take the drug in patients who are taking psychotropic painkillers.

Do not use simultaneously with alcohol, homogeneous substances and morphine antagonists, central neurological inhibitors, other derivatives of morphine.

Long -term drinking high -dose acetaminophen increases the anticoagulant effects of cooumarin and indoors.

Out of alcohol too much and long can increase the risk of acetaminophen toxic to the liver.

Anti -convulsions (including Phenytoin, Barbiturat, Carbamazepin) that causes enzyme induction in the liver microsom, which can increase the toxicity of the liver toxicity of acetaminophen.

Pay attention to the possibility of serious antipyretics in patients using simultaneously phenothiazine and cooling therapy.

Storage

In a dry, cool place (below 30 ° C). Avoid light.

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