Tatanol Forte antipyretic, analgesic (30 blisters x 5 tablets)

Dosage form Box of 30 blisters x 5 tablets
Specifications Acetaminophen

Ingredient

Composition information	Content
Acetaminophen	650mg

Uses

indications

Medicines have analgesic, antipyretic.

Treatment reduces the pain caused by the flu, headache, sore throat, muscle aches, toothache, migraine.

can be coordinated in the treatment of pain or fever.

Pharmacokology

Tatanol Forte with the main active ingredient is Acetaminophen is a typical antipyretic, pain relief. Reducing the feeling of pain in the headaches, muscle aches, and pain often seen in the cold
flu.

Pain relief mechanism: Prostaglandin synthesis inhibitors - Intermediate pain.

A reducing fever mechanism: Prostaglandin synthesis in inhibitor in the hilly -hilling center center causes peripheral vasodilation, resulting in increased blood circulation through the skin, increasing sweating and cooling down.

pharmacokinetics

absorption

Acetaminophen is quickly absorbed and almost completely through oral.

Tmax 1-3 hours. Prolonged time for 3-4 hours.

The pharmacokinetic parameters in milk when the mother takes the only dose of 650 mg.

Tmax 1-2 hours. CMAX 10-15mg/ml. I am 1.35-3.5 hours.

Distribution

Quick distribution to all tissues. Mount with plasma protein. The ratio of cohesion to plasma protein is from 10% - 25%. The ratio of cohesion with plasma protein is negligible when using the dose for plasma concentrations

Metabolism

About 90-95% of the dose is metabolized in the liver mainly due to a combination of glucuronic acid, sulfate and cysteine. The metabolism is very fast and has accumulated in case of overdose after the metabolic lines are mainly saturated. When the drug is accumulated, it can be toxic to the liver and kidneys.

Elimination

Semi-cancellation time: T1/2 about 1-4 hours. The sale time does not change in the case of renal failure but lasts in the case of acute overdose, some types of liver diseases, the elderly, newborns.

Elimination: Elimination through urine is mainly in the form of combined. In adults, 60% of the dose is excreted in the form of a glucuronic acid, 30% associated with sulfate, 4% associated with cysteine and mercapturic, about 3% excreted in constant form.

In children the same excretory ratio but in the form of sulfate more, the form is associated with less glucuronic.

Before taking Tatanol Forte antipyretic, analgesic (30 blisters x 5 tablets)

How to use

Tatanol Forte is used by oral.

Dosage

Adults and children over 12 years: 1 tablet/ time, 4 - 6 hours apart. Do not exceed 6 tablets/24 hours.

can increase the dose in case of necessity and should consult a doctor.

Children 6 - 12 years old: 1/2 capsules x 1 time, minimum 4 hours apart. No more than 2 tablets over 24 hours.

What to do when overdose?

Symptoms: diarrhea, anorexia, nausea, vomiting, abdominal pain, increased sweating, liver poisoning. These symptoms usually appear in the first 24 hours and may still occur after 2-4 days.

Treatment: Must be transferred to the hospital immediately, causing vomiting or gastric lavage to eliminate drinking drugs.

Activated carbon (activated carbon can reduce the effectiveness of treatment when taking acetylcysteine to treat overdose acetaminophen).

Using specific antidote N-acetylcystein, n-acetylcystein works when taken or intravenously.

Must give the drug immediately if less than 36 hours after taking acetaminophen. Treatment with n-acetylcysteine is more effective when giving the drug for less than 10 hours after taking acetaminophen. When drinking, dilute N-acetylcystein solution with water or drinks without alcohol to achieve a 5% solution and must be taken within 1 hour after mixing. Give N-acetylcystein oral at the first dose of 140 mg/kg, then give 17 more doses, each dose of 70 mg/kg every 4 hours apart. Termination of treatment if acetaminophen test in plasma shows the risk of low liver toxicity.

Display in case after 24 hours of overdose without being treated with n-acetylcysteine.

Treatment of overall support, maintenance of water balance, electrolytes.

What to do when forgetting the dose?

Add dose as soon as you remember. However, if the time to relax with the next dose is too short, skip the forgotten dose and continue the calendar of Tatanol Forte. Do not use double dose to compensate for missed dose.

Side Effects

Skin rash and other allergic reactions occur. Usually the erythema or urticaria, but sometimes worse and may be accompanied by fever due to drugs and mucosal lesions.

Patients with hypersensitivity to rare salicylate sensitive to acetaminophen and related drugs. In a few separate cases, acetaminophen has caused neutropenia, thrombocytopenia and hypoglycemia.

Uncommon: Ban; Nausea, vomiting, hematopoietic disorders (neutropenia, all bloody hemorrhage, leukopenia), anemia, kidney disease, kidney toxicity when abused for a long time.

Rare: Hypersensitivity reaction.

Notice the unwanted physician when using Tatanol Forte.

Warnings

Contraindicated

Tatanol Forte is contraindicated in the following cases:

Patients who are sensitive to the ingredients of the drug.

Severe liver failure.

Precautions when using

Should be cautious when using drugs in patients with severe renal impairment (cler

Consult your doctor if the symptoms last more than 10 days.

Doctors need to warn the patient about signs of serious skin reactions such as Steven-Johnson syndrome, toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

The effect of drugs on driving and operating machinery

The drug does not affect driving and operating machinery.

Pregnant and lactating women

Pregnant women: The safety of acetaminophen has not been determined when pregnant is related to unwanted effects that may have for fetal development. Therefore, only acetaminophen should only be used in pregnant people when needed.

Lactating women: Researching in mothers using acetaminophen after lactation, no unwanted use in breastfeeding.

Drug interaction

Need to pay attention to the likelihood of serious antipyretics in patients with phenothiazine and cooling therapy.

Out of alcohol too much and long can increase the risk of acetaminophen toxic to the liver.

Anti -convulsions (including Phenytoin, Barbiturat, Carbamazepin) that causes enzyme induction in the liver microsom may increase the toxicity of the liver.

Concentrated with toxic drugs on the liver increases the risk of toxicity on the liver.

Anticoagulants: High doses of acetaminophen causes increased anticoagulant effect.

Storage

In a dry, cool place (below 30 ° C). Avoid light.

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