Tavanic 500mg Sanofi medicine for bacterial infections (1 blister x 5 tablets)

Dosage form Box of 1 blister x 5 tablets
Specifications Levofloxacin

Ingredient

Composition information	Content
Levofloxacin	500mg

Uses

Indications

Tavanic 500mg medicine are indicated in the following cases:

Treatment of infections caused by bacteria sensitive to levofloxacin caused in adults:

Acute sinusitis.

Before prescribing Tavanic, it is advisable to pay attention to the nation's and/or local guidelines about the rational use of fluoroquinolon.

Pharmacology

levofloxacin is a synthetic antibiotic belonging to the Fluoroquinolon group. It is the isomers of the image s (-) of ofloxacin radical.

Mechanism of action: is a bactericidal antibiotic Fluoroquinolon, Levofloxacin inhibits the synthesis of bacteria by acting on the Gyrase and Topoisomerase IV DNA complex. Levofloxacin has high bactericidal in vitro. Levofloxacin has wide antibacterial spectrum on many types of gram -positive and gram -negative bacteria such as staphylococci, streptococci including pneumococci, enterobacteriaceae, Haemophilus influenzae, non -fermented gram -negative bacteria and non -typical bacteria.

Resistance mechanism: The mechanism of resistance is mainly based on Gyr-A mutation. In vitro, with cross -resistance between levofloxacin and other fluoroquinolones. Due to the impact mechanism, usually there is no cross -resistance between levofloxacin and other antibiotics.

pharmacokinetic

absorption

Levofloxacin is used to be absorbed quickly and almost completely, reaching the peak concentration in plasma for about 1 hour. Absolute bioavailability is approximately 100%. Eating less affects the absorption of levofloxacin.

Distribution

about 30-40% levofloxacin attached to serum protein. The repeated dose of 500mg levofloxacin once a day shows insignificant accumulation. There is a modest Levofloxacin accumulation but predicted after the dose 500mg twice a day. Stable blood concentration is achieved after 3 days. Good penetration into bone tissue, puffiness and lung tissue, but poor penetration into cerebrospinal fluid.

Biological Change

Levofloxacin is very small, metabolic substances are desmethyl-levofloxacin and levofloxacin n-oxide. These metabolites account for

Elimination

After taken and intravenous injection, Levofloxacin is relatively slowly eliminated from plasma (t1/2 = 6 - 8 hours). Excretion mainly through the kidney (> 85% dose). There is no much difference in levofloxacin pharmacokinetics after intravenous injection and after drinking, suggesting that intravenous and oral infusion can be replaced.

Before taking Tavanic 500mg Sanofi medicine for bacterial infections (1 blister x 5 tablets)

How to use

always use Tavanic 500mg as the doctor has instructed.

You should ask your doctor or pharmacist if anything is unknown.

How to use tavanic film tablets:

The drug is taken through the mouth.

swallow the tablet with a glass of water.

Tavanic tablets can be divided horizontally to the appropriate dose.

can take medicine at meals or at any time between meals.

Skin protection to avoid sunlight

It is necessary to avoid direct sunlight during Tavanic. Your skin will be more sensitive to the sun and may burn, burn or blister if not applicable to the following measures:

Use sunscreen with high index.

avoid sunbathing.

If you are taking iron tablets, antacids or sulcralfat , zinc supplements

Do not take these medications at the same time as the tavanic film. Should drink at least 2 hours before or after taking tavanic film tablets.

If you stop using Tavanic

Don't stop using Tavanic yourself just because you feel better. It is important that you complete the Tavanic course that the doctor has prescribed for you. If you stop using Tavanic too early, infection will recur, your condition may be worse or bacteria will become resistant. If you have any more questions about using Tavanic, ask your doctor or pharmacist.

Dosage

Tavanic is used once or twice daily. Dosage depends on the type and severity of the infection and the sensitivity of the hypothetical pathogen.

Treatment time

Duration of treatment varies depending on the type of disease (see below). As for antibiotic treatment in general, it is advisable to continue using Tavanic for at least 48 to 72 hours after the fever is gone or there is evidence of bacterial deduction

Dosage in patients with normal renal function (clearinin> 50ml/minute)

Indications

Dosage daily (depending on heavy levels)

Date 10 - 14 days Date

Urinary tract infections 250mg once a day 3 days Chronic bacterial paralysis 500mg once a day 28 days Circuit

Because levofloxacin is mainly excreted in urine, the dose reduction in patients kidney failure . Related information is presented in the following table:

First: 500mg First dose: 500mg Next: 125mg/48 hours Next dose: 125mg/24 hours The next dose: 125mg/12 hours Now next dose: 125mg/24 hours Precautions for patients with liver failure

Elderly patients

No dose adjustment on the elderly, in addition to considering the possibility of impaired renal function.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

The most important signs expected to occur after an acute overdose of Levofloxacin are the symptoms of the central nervous system such as confusion, dizziness, perception, and seizures, digestive tract reactions such as nausea and long -lasting mucosa.

If an overdose occurs, patients should be closely monitored (including ECG test) and symptomatic treatment should be conducted. In case of an overdose of oral medication, gastric lavage should also be considered and antacids can be used to protect the stomach lining. Dialysis, including peritoneal and peritoneal fertilizer, is constantly working, not effective to eliminate levofloxacin from the body. There is currently no specific antidote.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Tavanic 500mg, you may experience unwanted effects (ADR).

Like all other drugs, Tavanic can cause side effects, although not everyone meets. These side effects are usually light or moderate and often disappear after a short time.

Stop taking Tavanic and see a doctor or go to the hospital immediately if you notice the following side effects:

Very rare (occurring in

Allergic reaction. Signs may be rashes, difficulty swallowing or shortness of breath, lips, face, throat or tongue.

Stop taking Tavanic and see your doctor immediately if you notice any of the following serious side effects - You may need to be emergency treatment.

Rare (occurring in

Watery or bloody diarrhea, may be accompanied by abdominal cramps and high fever. These may be signs of a serious intestinal disease.

Pain and tendonitis. The most common is the heeled tendon (tendon Achille) and in some cases can be broken.

seizures (epilepsy).

Very rare (occurring in

A burning sensation, needle, pain or numbness. These may be signs of nerve disease.

Other reactions

Heavy rash on the skin, can puffiness and peeling the skin around the lips, eyes, mouth, nose, and genitals.

Anorexia, jaundice and yellow eyes, dark urine, itching, or pain when pressed on the upper abdomen. These may be signs of liver disease.

Common (occurring in

Nausea and diarrhea.

increases the liver enzyme in the blood.

Uncommon (occurring in

Itching and rash on the skin.

Anorexia, digestive disorders or indigestion, vomiting or pain in the stomach area, feeling of bloating or constipation.

headache, dizziness, dizziness, sleep disorders or nervous stress.

Blood tests may give abnormal results due to liver and kidney disorders.

Change the number of white blood cells in the results of some blood tests.

weak strength.

Increase the number of other bacteria or fungi, may need treatment.

Rare (occurring in

The needle feeling in the hands and feet (weird) or tremor.

The feeling of stress (anxiety), depression, mental issues, irritation or confusion.

Abnormal tachycardia or hypotension.

joint pain or muscle pain.

Bloody and easy to bleed due to a decrease in platelets.

Reduce the number of white blood cells.

Difficulty breathing or wheezing (bronchospasm).

Itching or urticaria.

Skin increases with sunlight and ultraviolet rays.

Reduce blood sugar (hypoglycemia). This is an important reaction to people with diabetes.

Hearing disorders or vision, or change the taste and smell.

hear or see things that are not real (hallucinations), change thoughts and thinking (psychotic reactions) with the risk of intentional or suicidal action.

circulating (reaction like anaphylaxis).

muscle weakness, may be serious in patients with myasthenia gravis (a rare disease of the nervous system).

Hepatitis, kidney dysfunction and sometimes kidney failure may be due to allergic reactions in the kidneys, also known as interstitial nephritis.

Fever, sore throat and unwell feeling. These symptoms may be due to reduced number of white blood cells.

Fever and allergic reactions in the lungs.

Other side effects

Reduce the number of red blood cells (anemia). The skin may be re -or yellow due to the destruction and reduction of the number of all types of blood cells.

The immune response is too strong (hypersensitivity).

sweat a lot (increasing sweating).

Pain, including back pain, chest and limbs.

Difficult to move and travel.

Porphyrin metabolic disorders in humans have this disease (a very rare metabolic disease).

vasculitis caused by allergic reactions.

extends QT on the electrocardiogram.

Abnormal tachycardia, arrhythmias are life -threatening.

loss of smell and taste.

tinnitus.

increases the blood in the blood.

Li Li Lan.

coma hypoglycemia.

Increase bilirubin.

Severe liver damage, including cases of acute liver failure, sometimes fatal.

There is an unusual, nightmare dream.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Tavanic medicine 500mg contraindicated in the following cases:

You have allergies to levofloxacin, or with any other quinolon antibiotics such as moxifloxacin, ciprofloxacin or ofloxacin or allergic to any other component of Tavanic.

You have epilepsy.

You have had muscle tendon pain like tendonitis associated with the treatment of quinolon antibiotics.

You are children under 18 years old.

You are pregnant, may be pregnant or think you are pregnant.

You are breastfeeding.

Do not use Tavanic if you have any of the above factors. If you are not sure, please consult your doctor or pharmacist before taking Tavanic.

Be cautious when using

Ask your doctor or pharmacist before taking the drug if you:

is the elderly (from 65 years old).

is using corticosteroids, sometimes called steroids (see "drug interactions and other interactions" below).

There was a faint or shocking (illness).

has had brain damage due to stroke or other brain injury.

There is kidney disease.

has glucose-6-phosphate dehydrogenase deficiency. You will be more likely to have serious blood problems when using Tavanic.

has had mental disorders.

There was a heart disease.

is a patient with diabetes.

has liver disease.

should be cautious when using fluoroquinolon, including levofloxacin, on patients who know there are risk factors that extend the QT interval such as: electrolytic disorders have not been adjusted (eg hypotension, hypoglycemia), congenital QT syndrome, heart disease (for example, heart failure, cardiac infarction) Elderly and women may be more sensitive to drugs that extend QT.

There is a history of myasthenia gravis. If you are not sure if you have the above or not, please consult a doctor or pharmacist before taking Tavanic.

The ability to drive and operate machinery

You may experience side effects after using Tavanic, including the feeling of dizziness, drowsiness, dizziness or visual change. Some of these side effects can affect your ability to focus and react speed. If occurred, do not drive or do anything that needs attention.

Pregnancy

Do not use Tavanic if you are pregnant, may be pregnant or think you are pregnant.

Breastfeeding period

Do not use Tavanic if you are breastfeeding or breastfeeding. Consult your doctor or pharmacist before taking any medication if you are pregnant or breastfeeding.

Drug interaction

notify the doctor or pharmacist if you are taking or recently used any other drugs, including non -prescription drugs, including herbs. This is because Tavanic can affect the impact of some other drugs. In contrast, some other drugs may affect Tavanic's action mechanism.

In particular, let the doctor know if you are taking any of the following. Because they can increase the likelihood of side effects when you share with Tavanic:

corticosteroid, sometimes called steroids - used for anti -inflammatory. You will most likely get inflamed or tendon.

Warfarin - Used to prevent coagulation. You will most likely bleed. Your doctor needs regular blood tests to check your clotting condition.

Theophyllin - used in respiratory disease. You will most likely faint or shock (disease) if used with Tavanic.

anti -inflammatory drug (NSAIDS) - used to treat pain and inflammation, such as aspirin, ibuprofen, fenbufen, ketoprofen and indomethacin. You will most likely be fainted or shocking (disease) if used with tavanic.

ciclosporin - used after organ transplantation. You will most likely experience the side effects of ciclosporin.

The drug affects the heart rate. This group includes abnormal heart rate treatment (anti -arrhythmias such as quinidine and amiodaron), depression (three -ring antidepressants such as amitriptylin and imipramine), some anti -psychotic drugs, and infections (macrolide antibiotics such as erythromycin, azithromycin and clarithromycin).

Probenecid - Used to treat gout and cimetidine - Use to treat stomach ulcers and heartburn. It is necessary to be careful when sharing these drugs with Tavanic. If you have kidney disease, the doctor will give a lower dosage.

Do not use tavanic film tablets at the same time with the following drugs, as they can affect the mechanism of Tavanic's action: iron tablets (anemia), antacids containing magnesi or aluminum (acid excess or heartburn) or sulcralfate (stomach ulcer treatment), zinc supplements (see items: how to use).

Division of opium in urine

Urine tests can give a strong positive result with a strong analgesic drug as an opium family in people who are taking Tavanic. If the doctor asks for an urine test, let the doctor know you are using Tavanic.

Storage

Leave on the reach and eyes of children.

Do not store drugs at a temperature of more than 30 ° C, store drugs in blisters and boxes in a dry place.

Do not cancel the drug through the wastewater or domestic water. Ask the pharmacist about how to destroy the drug no longer needed. These measures will help protect the environment.

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