Tazlex davipharm medicine before thyroid surgery (10 blisters x 10 tablets)
Dosage form Box of 10 blisters x 10 tablets
Specifications Methimazole
Ingredient
| Composition information | Content |
| Methimazole | 5mg |
Uses
Indications
pharmacokinetic
absorption
methimazol quickly absorbed through the digestive tract. If drinking with food, unpredictable absorption. The peak concentration of plasma is achieved within 1 hour after drinking. Born is 93%. For healthy people to take 60 mg of methimazol, the peak concentration is 1.8 μg/ml.
Distribution
methimazol focuses heavily on the thyroid. The distribution volume 0.6 l/ kg. The drug is associated with negligible plasma proteins. The drug can pass the placenta and secret the breast milk with the concentration of the mother's plasma concentrations.
Metabolism
Maximum medication is mainly in the liver. The metabolite has not been detected. The sale time is 3 - 6 hours. When liver failure, the kidneys are sold for prolonged waste.
Elimination
The drug is eliminated in the urine in the form of 3-methyl-2-thiohydintin metabolites that are the main metabolites of methimazol. Under 10% of methimazol is eliminated in a constant form.
Before taking Tazlex davipharm medicine before thyroid surgery (10 blisters x 10 tablets)
How to use
The drug does not cure the cause of hyperthyroidism. Depending on the severity of hyperthyroidism, choose the appropriate dose. For adults, daily dose of 15 - 60mg, divided equally into 3 times, each time 8 hours apart. The drug can be taken 1-2 times, the effect may be poor, but in some people, the unwanted effect is less and the patient is easier to accept. Time to use drugs for regression disease must be long -term, usually ranging from 6 months to 1-2 years.
Should take medicine with a full glass of water and take it at the same time of the day.
Dosage
Adults
hyperthyroidism:
The starting dose is 15mg/day for mild thyroid hyperplasia, 30 - 40mg for moderate cases and 60mg for severe cases divided into 3 oral doses about 8 hours apart. The maintenance dose is 5 - 15mg/day.
Symptoms of hyperthyroidism usually support within 1-3 weeks and end within 1-2 months after the initial dose. Once the condition is achieved, the dose gradually reduces the maintenance dose.
Due to the risk of granulocytes at a dose greater than 40mg, the dose should be lower than 30mg/day when possible.
Preparation of surgery:
The starting dose is 15mg for mild thyroid energy, 30 - 40mg in medium case and 60mg for severe cases.
Stop methimazol during surgery.
Prepare to use radioactive iodine:
The starting dose is 15mg for mild thyroid energy, 30 - 40mg for moderate cases and 60mg for severe cases.
It is recommended to stop methimazol 2 - 7 days before using radioactive iodine; Methimazol may be reused 3 - 7 days after using radioactive iodine, then stopped for 4-6 weeks when the normal armor function and radioactive iodine are effective.
Armor poisoning:
Take 15 - 20mg, every 4 hours of the first day, with other treatments. Dose adjustment depending on the patient response.
Children
hyperthyroidism:
Daily daily daily -doses are 0.4mg/kg body weight divided into 3 doses, 8 hours apart. The maintenance dose is about ½ of the starting dose.
Preparation of surgery:
Daily dose of daily buckles 0.4mg/kg body weight divided into 3 oral doses 8 hours apart.
Recommended the use of methimazol about 1-2 months for thyroid jar before surgery to remove thyroid glands in Graves patients.
Stop drugs during surgery.
Prepare to use radioactive iodine:
Daily dose of daily buckles 0.4mg/kg body weight divided into 3 oral doses 8 hours apart.
Recommendation of stopping methimazol 3 - 5 days before radioactive iodine therapy. In children rarely require to start using anti -thyroid medication after radioactive iodine therapy.
Special subjects
No specialized recommendations for patients with liver, kidney and elderly patients.
Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.
What to do when overdose? Soldier anemia (reducing all bloody hemodiac) or grain leukemia can be seen for hours until all day. Less common hepatitis, nephrotic symptoms, dermatitis, scales, neuropathy, central stimulation, depression. Although not clearly researched, methimazol causes grain leukemia is often associated with a dose of 40mg or more in patients over 40 years old.
There is no information about methimazol's LD50 in organisms related to toxicity and death.
Handling: If you have just taken overdose, causing vomiting or gastric lavage. If the patient is in a coma, convulsions or no vomiting reflexes, the stomach may be lavely after the intubation has a stretched balloon to avoid inhaling the substances contained in the stomach. Medical care, symptomatic treatment, antibiotic or corticosteroids may be used, blood transfusion if the marrow failure and severe leukopenia.
What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.
Side Effects
Common, ADR> 1/100
Uncommon, 1/1000 Peripheral neuritis: peripheral neuritis. Rare, ADR Lung: interstitial pneumonia. Instructions on how to handle ADR rash, itching, usually in the form of lumpy, often lost during treatment, stopping the drug if the rash is severe. If you see signs of liver toxicity (jaundice of cholestasis, liver necrosis), it is necessary to stop the drug. Although very rare, there have been cases of death. Jaundice may last more than 10 weeks after methimazol stops. In the case of clear symptoms of cardiovascular toxicity, especially tachycardia, it is necessary to combine beta blockers (propranolol, atenolol).
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
Contraindicated
Precautions when using
Hematology effects:
The risk of granulocytes usually occurs within the first 2 months after the beginning of treatment, rarely occurs after 4 months of treatment. This may depend on the dose (usually occurs in higher doses); However, it may not depend on the dose, treatment time, or before using anti -thyroid drugs, and may occur more than the elderly.
leukopenia, thrombocytopenia, anemia, hypoglycemia and bleeding may occur.
blood formula test before starting treatment for Graves - immune hyperthyroidism.
Carefully monitor signs and symptoms (neck pain, rash, fever, chills, headache, body fatigue), especially in the early stages of treatment. If there are these signs, leukocytes and other blood cells see if they are lost.
If granulocytes and anemia occur, stop methimazol and monitor bone marrow function. In patients with grain leukemia or other serious side effects when using methimazol or propylthiouracil, contraindicated use of the remaining drug due to the risk of cross -sensitivity between two drugs.
Liver toxicity
The risk of liver toxicity (including acute liver failure) in methimazol may be lower than propylthiouracil, especially in children.
jaundice due to methimazol may last a few weeks after stopping the drug.
Check the liver function (alkaline phosphatase, aminotransferase, bilirubin) before starting treatment in patients with Graves.
Review liver function immediately (alkaline phosphatase, bilirubin) and liver damage (AST, ALT) if there are symptoms of impaired liver function (anorexia, upper right abdominal pain). If there is clinical liver function abnormalities (aminotransferase liver> 3 times the normal limit above), stop methimazol immediately. If hepatitis occurs, stop methimazol.
Thyroid reduction
The thyroid reduction may occur, it is necessary to regularly monitor the concentration of TSH and T4 freely, adjust the dose to reach the state of the armor.
The drug can cause goiter and dull because the drug can pass the placenta.
Hypersensitivity reaction
Diagonal hypersensitivity between possible thioamids (in about 50% of patients converts one of one of one to another).
In patients with serious unwanted effects (loss of grain leukemia) when using methimazol or propylthiouracil, contraindicated use of the remaining drug due to the risk of hypersensitivity can occur between the two drugs. If the patient has a serious allergic reaction when using methimazol, it is not recommended to use other anti -thyroid drugs (propylthiouracil).
Other cautionBefore treatment with thioamid in Graves patients, recommendation of free T4 concentration and TSH, blood formula, liver function test.
Monitor the periodic armor function (free t4 in serum, free or total serum, TSH) every 4 - 8 weeks; When the state is reached, monitor the armor function every 2-3 months.
Serly TSH is not a reliable measure when monitoring the first stage of treatment because it can decrease in a few months after the beginning of treatment, although the T4 concentration is free. TSH decreased during this time could not say that it was necessary to increase the dose. However, when increased thyroid function is resolved, reducing maintenance dose if serum increases. Monitoring T3 serum is sometimes helpful in adjusting the dose; If total or free T3 concentration still increases, although the concentration of free T4 decreases or is low normally; May need to increase anti -thyroid dose. When stopping methimazol in Graves patients, monitor the armor function every 1-2 months within 6 - 12 months to detect early when the disease recurs.
Monitoring blood counts in patients shows signs or symptoms during treatment.
Monitor prothrombin time, especially before surgery, due to the risk of reducing blood and hemorrhage prothrombin.
If peeling dermatitis occurs, stop methimazol.
A positive vasculitis with antibodies of neutrophils (ANCA), acute kidney failure, arthritis, skin ulcers, bleeding rarely are rarely reported. If happened, stop methimazol.
methimazol is prioritized more than propylthiouracil when used in children due to a serious liver damage report (liver failure requires liver transplant surgery or death) in children due to propyliouracil. There is no similar report to methimazol.
The ability to drive and operate machinery
The drug can cause dizziness and drowsiness. Be cautious when driving or operating machinery.
Pregnancy
methimazol through the placenta and can be harmful to the fetus (goiter, thyroid disobsk, some defects in the fetus are growing but the risk is often low, especially when low doses).
Need to consider benefits and risks. In case of treatment, propylthiouracil is often used because through the placenta less than methimazol. When using methimazol, the lowest dose is effective to maintain the mother's armor function at a high level within the normal limit of normal pregnancy, especially in the last 3 pregnancy. Reducing thyroid and goiter ability in the fetus often occur when taking anti -thyroid medication near the date of birth, because the fetal thyroid has not produced armor hormone until 11 or 12 weeks of pregnancy. Increasing armor can decrease in the mother when the fetus progresses, so in some people can reduce the dose of methimazol, sometimes stop treatment for 2-3 weeks before birth.
Hormone armor through the placenta is very small, so it is less likely to protect the fetus. Utid hormones should not be used during pregnancy because the drug can cover the signs of regression of hyperthyroidism, avoid increasing the dose of methimazol useless, causing more harmful effects on the mother and the fetus.
Breastfeeding period
methimazol distributed into breast milk, causing complications for children. The concentration of drugs in plasma and breast milk is almost equal so do not breastfeed when the mother uses methimazol.
Drug interaction
When hyperthyroidism, aminophylline metabolism, oxtriphyline, theophyllline increases. Use methimazol, if the thyroid gland returns to normal, it is necessary to reduce the dose of these drugs.
Amiodaron, iodoglycerides, iodine or potassium iodid drugs that have iodine reduces the body's response to methimazol, so it is necessary to increase the dose of methimazol.
Need to adjust the anticoagulant dose of coagararin or indandion when combining these drugs with methimazol can reduce blood prothrombin, increasing the effect of oral anticoagulants.
Hypothyroidism increases metabolism and eliminates Beta or cardiac blockers or cardiac glycosides, which need to reduce the dose of these drugs when the patient's thyroid gland returns to normal due to methimazol use.
methimazol reduces the radioactive iodine iodine collection 131i into the thyroid gland. If the methimazol stops suddenly, after about 5 days will recharge 131i.
Storage
In a dry place, avoid light, the temperature does not exceed 30 ° C.
Other drugs
- Champix
- DECA-DURABOLIN 50MG/ML INJECTION
- FERROGRAD C TABLETS
- LIPANTHYL 200MG MICRONISED CAPSULES
- NovoRapid
- VALACICLOVIR 500MG TABLETS
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Popular Keywords
- metformin obat apa
- alahan panjang
- glimepiride obat apa
- takikardia adalah
- erau ernie
- pradiabetes
- besar88
- atrofi adalah
- kutu anjing
- trakeostomi
- mayzent pi
- enbrel auto injector not working
- enbrel interactions
- lenvima life expectancy
- leqvio pi
- what is lenvima
- lenvima pi
- empagliflozin-linagliptin
- encourage foundation for enbrel
- qulipta drug interactions