Tazoretin -on skin - C Gel 15g Medisun treats acne on the spot

Dosage form Tube x 15g
Specifications Clindamycin, Adapalene

Ingredient

Composition informationContent
Clindamycin100mg
Adapalene10mg

Uses

indicated

Tazoretin-C gel tube used in acne treatment.

Pharmacology

Pharmacological group: Acne treatment.

ATC code: D10AD53.

adapalen:

Adapalen is a retinoid compound that has been shown to have anti -inflammatory activity in vivo and in vitro; Adapalen is sustainable with oxygen and light and has no chemical reaction. The mechanism of action of Adapalen, like tretinoin, is to cohesion to the specific retinoic acid receptor of the nucleus, but different tretinoin is not attached to the protein of the receptor in the cytoplasm.

Adapalen when used on the skin has the effect of decomposing acne and also works on the abnormalities of the process of horny and differentiation of the epidermis, both of these cases are acne factors. The mechanism of action of adapalen is to normalize the differentiation of epithy cyst cells and thus reducing the formation of acne micro -acne.

clindamycin:

Clindamycin is an antibiotic belonging to the Lincosamid group. The mechanism of action of clindamycin is to link to the mini part of ribosom, thus inhibiting bacterial protein synthesis. Clindamycin has a bactericidal effect in low concentrations and bactericidal at high concentrations

Bacterial resistance mechanism for clindamycin is methylation of RNA in the ribosom part of the bacterial ribosom; This type of resistance is usually through plasmid intermediaries. There is a cross -resistance between clindamycin and erythromycin, because these drugs act on the same position of bacterial ribosom.

antibacterial spectrum

Air -demand Gram -positive bacteria: Streptococci, Staphylococci, Bacillus anthracis and Corynebacterium diphteriae. Anaerobic gram -positive bacteria: Eubacterium, propionibacterium, peptococcus, peptostreptococcus spp, multiple strains of clostrium perfringens and C. Tetani

Some Actinomyces spp strains. and Norcardia Asteroides.

A few anti -resistant toxoplasma gondii and Plasmodium spp.

pharmacokinetics

adapalen:

In humans, Adapalen is absorbed through poor skin; In clinical trials, the adapalen concentration in plasma is not found at a measured level when used long -term on a wide skin area with acne with analytical sensitivity level of 0.15 ng/mL. Therefore, it is not possible to identify the pharmacokinetic parameters about the bioavailability of adapalen when applying on the skin.

clindamycin:

Absorption: a small amount of clindamycin can be absorbed when using the skin on the spot. The bioavailability of clindamycin phosphate when used on the spot is 2%.

Distribution: Clindamycin is widely distributed in the fluid and tissue of the body, including bone, but the distribution does not achieve clinical significance in cerebrospinal fluid. The drug diffuses through the placenta during pregnancy, the drug also appears in breast milk and has high concentrations in bile. Over 90% of the drug concentration within the circulation is linked to plasma proteins. The half-life of the drug is 2-3 hours but can last for newborn babies and people with severe kidney failure.

Metabolism: The metabolic drug in the liver forms N-Demethyl and Sulfoxid metabolites that are active and some other metabolites are not active.

Elimination: About 10% of the dose is excreted in the urine in the form of activity or metabolites and about 4% excreted in stool.

Before taking Tazoretin -on skin - C Gel 15g Medisun treats acne on the spot

How to use

Tazoretin-C gel tube is applied to the skin.

Dosage

Apply thin layer to the disease area after washing and dry, 1 time/day in the evening before going to bed. Avoid gel wire in the eyes, lips, mucosa. In the first weeks, you can see the phenomenon of spreading acne. The results are recorded after 8 - 12 weeks of taking the drug.

Specific dose depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? In this case, it is necessary to gently wash the topical area with warm water or soap with mild cleaning properties and use only the drug if the side effects stop and disappear.

In case of overdose, Clindamycin can be absorbed into the body and affect the digestive tract, causing abdominal pain, nausea and vomiting, diarrhea ... Treatment of symptoms for patients in this case.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting 1 dose?

Side Effects

When using the drug, there are common unwanted effects (ADR) such as:

Less (≤1/100 but> 1/1000)

  • Acne, dry skin, red skin, increased oily secretion. Sensitive reaction, itching, rash, scales or sunburn.
  • irritation. blisters, red), nosebleeds, hot feeling, loss of skin pigmentation, skin irritation.

    • Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    contraindicated

    Tazoretin-C gel tube in the following cases:

  • Sensitive people with Clindamycin, Lincomycin or any ingredients of the drug.

    Caution when used

    Avoid eye contact, lips, nose angle, mucosa. Do not apply the drug on the cut, scratched, the skin of eczema, sunburned skin. Avoid exposing strong light. In case the drug is wired into the eye, it is necessary to wash immediately with plenty of water.

    Do not use the drug to treat mild acne cases.

    Do not use drugs for pregnant women, especially in the first 3 months of pregnancy and women are likely to become pregnant. Using the drug more or more the recommended amount can cause skin redness, aches, and discomfort. Especially if the reaction occurs in the early stages of treatment, the dose and frequency should be reduced.

    Cautions related to adapalen:

    Do not use the drug at the same time as other skin -use forms (including cosmetics) because there may be interactions with Adapalen. Especially for patients using products that have hair removal effects such as sulfur, salicylic acid, benzoyl peroxid or resorcinol and chemicals that cause abrasion effect. If the patient is using these products, it should gradually reduce the dose before starting with tazoretin-C.

    Medication products that have a cleaning and cleaning effect can cause strong skin dryness, so they should not use these products with patients who are using drugs containing retinone derivatives in general. Soap, cosmetics, spicy or sour spices should also be used carefully.

    Due to increased sensitivity to UV rays, patients need to reduce exposure to direct sunlight or strong light. In case of sunny, patients must use more sunscreen products (with the lowest SPF is 30) and protective equipment such as hats, masks, ... For patients who are sunburned, stop using the drug until the skin is no longer red.

    Products containing propylene glycol, methylparaben and propylparaben: can cause allergies on the skin.

    Cautions related to clindamycin:

    Antibiotic colitis has been reported in cases where patients use products from clindamycin.

    If the patient has prolonged diarrhea and abdominal cramps, the drug should be stopped immediately, as this may be a symptom of antibiotic colitis. The patient then needs to be diagnosed and treated appropriately.

    Clindamycin accumulates in people with severe liver failure, so the dose adjustments must be adjusted; If used for a long time, periodic monitoring of liver, kidney and blood cell formula should be monitored.

    Using clindamycin can cause bacteria that are not sensitive to over -growing drugs. It is necessary to monitor patients and make antibiotics regularly to take appropriate treatment.

    Clindamycin needs to be used carefully for people with severe kidney failure and liver failure, when using high doses for these patients need to monitor the clindamycin concentration in serum.

    Use carefully the types of products containing benzyl alcohol and tatrazin.

    Children

    Do not use drugs to treat central nervous system infections. Clindamycin is poorly tolerated in AIDS patients.

    Clindamycin is not safe for patients with porphirin metabolism, avoiding people with acute porphirin metabolic disorders.

    There may be cases where patients with folliculitis due to gram -negative bacterial infections due to the use of topical preparations containing 1% clindamycin. In this case, patients need to stop using the drug immediately and replace it with other treatments.

    Using preparations for too long can cause cases of drug and fungus. Cross resistance can occur with other antibiotic products such as Lincomycin or erythromycin.

    It is necessary to avoid using oral antibiotics and skin -use.

    Using drugs for women during pregnancy and lactation

    clinical data on a small number of patients using products containing adapalen or clindamycin does not see harmful reactions on both mother and child. However, animal research shows that the oral Adapalen can cause teratogenicity. Due to the lack of clinical data on humans and toxic effects on animals, the drug is contraindicated during pregnancy.

    For skin types used on the skin containing clindamycin or adapalen, there is no drug data whether or not breast milk, but clindamycin is excreted through breast milk when the patient uses oral medication. Hence contraindicated use of drugs for breastfeeding women

    The effect of the drug on driving and operating machinery

    The drug does not affect the ability to drive and operate machinery.

    Medicinal interaction

    Be cautious when used with products that can cause elsewhere, sulfur, resorcinol or salicylic acid. Taking neurotransmitter.

    Using drugs and products that have a strong cleaning effect or high alcohol content can cause dry skin.

    Avoid using the drug simultaneously with corticosteroids.

    Vitamin K anti -vitamin: Increased bleeding time has been reported in patients using clindamycin simultaneously and vitamin K anti -vitamin K medications.

    clindamycin:

    Clindamycin has the effect of nervous blockage, so it can increase the effects of other nerve maple medications, so should be used very cautiously when the patient is taking these drugs and these patients need to be monitored because of the prolonged nerve blockage effect.

    Clindamycin should not be used simultaneously with the following drugs:

  • Oral contraceptive oral contraceptives, because it reduces the effects of these drugs. Therefore, the link of this drug with ribosom bacteria can inhibit the effect of the other drug. Clindamycin. However, in vivo this resistance has not been proven, clindamycin has successfully used in combination with an aminoglycoside and unknown activity.

    • adapalen:

    No reports on interactions may occur when using Adapalen and other drugs. However, with retinoid drugs or drugs with the same mechanism of action, it should not be used simultaneously with Adapalen.

    Adapalen is stable with oxygen, light and chemical reactions. Although there is no reporting data on increased sensitivity to the safety light of adapalen on humans and animals, it is still advisable to avoid exposure to strong intensity or UV rays.

    Adapalen absorbs through the skin very low, so drug interactions related to body absorption are hardly occurring. There is no clinical evidence that the effectiveness of oral drugs such as birth control pills is affected by adapalen using skin sugar.

    Storage

    Store at a temperature not exceeding 30 ° C in the original packaging, avoid moisture and avoid light.

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