Telfadin 60mg Danapha treat allergic rhinitis, urticaria (1 blister x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 1 blister x 10 tablets
Ingredient Fexofenadine
Indication Allergic rhinitis, urticaria, atopic dermatitis, allergic conjunctivitis
Contraindication Chronic renal failure, liver failure

Ingredient

Composition information	Content
Fexofenadine	60mg

Uses

Indications

Danapha - Telfadin 60 mg is indicated in the following cases:

Treatment of symptoms in allergic rhinitis.

Pharmacology

Fexofenadin is a second -generation antihistamine drug with specific antagonistic and selective effects on H1 receptors. The drug is a metabolic substance that is active of terfenadin but is no longer toxic to the search due to not inhibiting potassium channels associated with myocardial cell red. Fexofenadin does not have an antagonistic effect of acetylcholin, dopamine antagonism and has no effect on inhibiting receptors of Alpha1 - Adrenergic, or Beta - AdrenerGie. At the treatment dose, the drug does not cause sleep or affects the central nervous system. The drug has a fast and prolonged effect due to the slow -attached drug into the H1 receptor to form a sustainable complex and slowly separated.

Pharmacokinetics

absorption

Good absorption drug when taken orally. After taking a 60 mg tablet, the blood concentration in the blood is about 142 ng/ml, achieved after 2-3 hours. Food reduces the peak concentration in plasma by about 17% but does not slow down the time to reach the peak concentration of the drug.

Distribution

The ratio of the plasma protein of the drug is 60 - 70%, mainly with albumin and alpha1 - Glycoprotein acid. The distribution volume is 5.4 - 5.8 liters/kg. It is unclear whether the drug is through the placenta or excretion in breast milk, but when using terfenadin has detected fexofenadin is the metabolic substance of terfenadin in breast milk. Fexofenadin does not pass the blood - brain barrier.

Metabolism

approximately 5% of the dose of the drug is metabolized. About 0.5 - 1.5% are metabolized in the liver thanks to the cytochrom P450 enzyme system into non -active substances. 3.5% are converted into methyl ester derivatives, mainly thanks to the intestinal bacteria.

Elimination

Half of Fexofenadin elimination is about 14.4 hours, longer in renal failure. The drug is excreted mainly in feces (approximately 80%), 11 - 12% of the dose is eliminated through urine in constant form.

Before taking Telfadin 60mg Danapha treat allergic rhinitis, urticaria (1 blister x 10 tablets)

How to use

oral medication, time to take the drug regardless of the meal.

Dosage

Adults and children aged 12 and older: 1 capsule 2 times/day.

Children under 12 years of age: Use other forms of preparation.

People with kidney failure: Adults and children aged 12 years and older suffer from kidney failure: 1 capsule x 1 time/day.

Hepatic failure: No dose adjustment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? There is no specific antidote for fexofenadin. Recommendations for symptomatic treatment or support for fexofenadin overdose occurs. Fexofenadin is not effectively removed by the method of appraisal.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Danapha - Telfadin 60 mg, you may experience unwanted effects (ADR).

common, ADR> 1/100

Neurological: Drowsy, tired, headache, insomnia, dizziness.

digestive: nausea, indigestion.

Other: viral infection (flu) dysmenorrhea, upper respiratory infection, itching throat, cough, fever, otitis media, sinusitis, back pain.

Uncommon, 1/1000

Neurological: Fear, sleep disorders, nightmares.

digestion: dry mouth, abdominal pain.

Rare: ADR

Skin: ban, you day, itching.

Hypersensitivity reactions: Evana, chest tightness, shortness of breath, redness, anaphylaxis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Danapha - Telfadin 60 mg contraindicated in the following cases:

Patients with a history of hypersensitivity to fexofenadin or any ingredients of the drug.

Be cautious when using

be careful to monitor when using fexofenadin for people who are at risk of cardiovascular disease or have a long -lasting QT range.

Be careful when taking more antihistamine drugs while using fexofenadin.

Be careful and adjust the appropriate dose when using drugs for people with renal function decreased because the drug concentration in plasma increases due to half -life elimination of the drug extended.

The ability to drive and operate machinery

although Fexofenadin is less likely to be drowsiness. But still need to be cautious while driving or operating machinery.

Pregnancy

There has been no good and complete studies for pregnant women. Fexofenadin should only be used during pregnancy when really necessary.

breastfeeding period

Fexofenadin is excreted through breast milk. It is recommended to be cautious when using fexofenadin for women who are breastfeeding.

Drug interaction

erythromycin and ketoconazole increases concentration and area under the concentration curve - the time of fexofenadin in the blood, the mechanism may be due to increased absorption and reduction of this drug. However, the interaction has no clinical significance.

Antacomicisted with aluminum, Magnesi if used simultaneously with fexofenadin will reduce the absorption of the drug, so it must be used by these drugs about 2 hours apart.

Storage

Leave the medicine in a dry place, avoid light, temperatures below 30 ° C.

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