Telgate 180mg Nic medicine supports the treatment of allergic rhinitis, urticaria (2 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 2 blisters x 10 tablets
Ingredient Fexofenadin HCl

Ingredient

Composition information	Content
Fexofenadin HCl	180mg

Uses

Indications

Telgate 180mg drug indicated symptomatic treatment in seasonal allergic rhinitis in adults and children over 6 years old, malefinity chronic urticaria in adults and children over 12 years old.

Pharmacokological

Fexofenadin is a second -generation antihistamine drug, which has a specific antagonistic and selective effect on peripheral H1 receptors. Fexofenadin is a metabolic substance that is active of terfenadin but no longer toxic to the heart due to not inhibiting potassium channel associated with myocardial cycles.

Fexofenadin has no significant effect on acetylcholin antagonism, dopamine antagonism and has no inhibiting receptor of Alpha 1 or beta - adrenergic. At the treatment dose, the drug does not cause sleep or affects the central nervous system. The drug has a fast and prolonged effect due to the slow -attached drug into the H1 receptor, forming a sustainable complex and separating slowly.

pharmacokinetics

The peak concentration in the blood is achieved after 2 to 3 hours. Fat -rich foods reduce the peak concentration in plasma by about 17% and extend the time to reach the peak concentration of the drug (until about 4 hours). Anti -antihistamine effect lasts more than 12 hours.

The ratio of the plasma protein of the drug is 60 to 70%, mainly with albumin and alpha1-acid glycoprotein. It is unclear whether the drug is through the placenta or excretion in breast milk, but when using terfenadin has detected fexofenadin is the metabolism of terfenadin in breast milk.

Fexofenadin does not go through blood-flabbit barriers. Fexofenadin is very little metabolized (about 5%, mainly in the intestinal mucosa. Only about 0.5 to 1.5% are metabolized in the liver thanks to the cytochrom P450 enzyme system into non -active substances). About 3.5% of fexofenadin dose metabolized through phase II (not related to the cytochrom P450 enzyme system) into methyl ester derivatives. This metabolic substance is only seen in the stool, so there may be the participation of intestinal bacteria in this metabolism.

FEXOFENADIN SELLING Time is about 14.4 hours, longer (31-72%) in people with kidney failure. The drug excreted mainly through the kidneys (approximately 80%) and urine (11-12%) in constant form.

Pharmacokinetics in people with renal failure:

CLCR 41 to 80 ml/minute: The peak concentration is higher than 87%, the sale time is longer than 59%. Strong.

Before taking Telgate 180mg Nic medicine supports the treatment of allergic rhinitis, urticaria (2 blisters x 10 tablets)

How to use

Tablets for oral tablets.

Dosage

Specific dose depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Telgate often has unwanted effects (ADR) such as:

Common

Neurological: Drowsy, tired, headache, insomnia, dizziness.

Neurological: nightmares, fear, dry mouth.

Digestive: dry mouth, abdominal pain

Skin: skin rash, itching.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Telgate drugs contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Precautions when using

although Fexofenadin is less likely to cause sleepiness, but still need to be cautious when driving or controlling machinery requires alertness.

Be careful and adjust the appropriate dose when taking drugs for people with impaired renal function because the drug level in plasma increases due to prolonged selling time. Be careful while taking the drug for the elderly (over 65 years old) often has renal physiological impairment.

Safety and effectiveness of drugs in children under 6 months of age has not been identified.

Need to stop Fexofenadin at least 24-48 hours before conducting injection antigen tests.

Use fexofenadin to make psoriasis worse.

Patients with cardiovascular disease, people with prolonged QT.

Drug interaction

erythromycin and ketoconazole increases fexofenadin levels in plasma but does not change the QT.

Fexofenadin concentration may increase due to erythromycin, ketoconazole, verapamil, p-glycoprotein inhibitors.

Unsuitable Fexofenadin with antacids containing aluminum, magnesi because it will reduce fexofenadin absorption.

Fexofenadin may increase alcohol concentration, TKTW sedatives, cholinergic substances.

Fexofenadin may reduce the concentration by acetylcholinininininiserase inhibitors (in TKTW), amphetamine, acid antacids, grapefruit juice, rifampin.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.