Telmisartan 40 TV.Pharm treat hypertension (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Telmisartan

Ingredient

Composition information	Content
Telmisartan	40mg

Uses

Indications

Telmisartan 40mg drug is indicated in cases of hypertension . Can be used alone or can also combine other anti -hypertension drugs.

Medicine

Telmisartan is a specific antagonist of Angiotensin II receptor in smooth and adrenal muscle. Angiotensin II is a vascular contraction agent, stimulating synthetic adrenal skin and releasing aldosteron, stimulating the heart. Aldosteron reduces sodium excretion and increases potassium excretion in the kidneys. Telmisartan prevents Angiotensin II into the AT1 receptor in blood vessel and adrenal glands, causing vasodilation and reducing the effects of aldosteron. Angiotensin II anti -receptor drugs do not inhibit bradykinin, no persistent cough effect, at the dose of 80 mg, Telmisartan completely inhibits hypertension due to angiotensin II.

Hypotension effects maintained for 24 hours and still works for 48 hours after drinking. After taking the first dose, the hypotension effect is manifested within the first 03 hours, in hypertension people, Telmisartan reduces systolic and diastolic blood pressure without changing the heart frequency. Telmisartan's anti -hypertension effect is equivalent to other drugs. When Telmisartan stopped suddenly, the blood pressure gradually returned as untreated, but there was no strong increase in the phenomenon.

pharmacokinetic

absorption

Telmisartan is quickly absorbed through the gastrointestinal tract, absolutely used orally depends on the dose: about 42% after taking the dose of 40 mg and 58% after taking the dose of 160 mg. Food affects the absorption, after drinking, the highest drug concentration in plasma is achieved after 0.5 -1 hours.

Distribution

more than 99% of Telmisartan attaches to plasma proteins, mainly on albumin and 1-acid glycoprotein. The attachment to the protein is constant, does not change according to the dose. The distribution volume is about 500 liters.

Metabolism - Elimination

After intravenous intravenous or telmisartan, about 97% of constant doses are excreted in biliary tract into the feces, very small amount

Hepatic failure

Telmisartan concentration in blood increased and absolutely bioavailable reached nearly 100%.

Before taking Telmisartan 40 TV.Pharm treat hypertension (3 blisters x 10 tablets)

How to use

Take it once a day, no meals.

Dosage

Adults:

40mg/1 time/day. If necessary, can increase to a maximum dose of 80mg/1 time/day.

Telmisartan can be combined with thiazid diuretics. Before increasing the dose, it should be noted that the maximum anti -hypertension effect is achieved between the 4th and 8th weeks from the beginning of treatment.

kidney failure:

No dose adjustment.

Hepatic failure:

If mild or moderate liver failure, daily dose must not exceed 40 mg/daily.

Elderly:

No dose adjustment.

Children under 18 years old:

Safety and efficiency have not been determined.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Treatment: Symptomatic treatment and support.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Telmisartan 40mg , you may experience unwanted effects (ADR).

Common, ADR> 1/100

Body: fatigue, headache, dizziness, limb edema, sweating.

Central nervous system: agitation. digestion: dry mouth, nausea, abdominal pain, acid reflux, indigestion, flatulence, anorexia, diarrhea .

urinary tract: Reducing kidney function, increased creatinine and nitrogen urea (bun), urinary tract infections.

Respiratory: Sore throat, sinusitis , upper respiratory tract infections (cough, congestion or ear pain, fever, nasal congestion, runny nose, sneezing, sore throat).

bone - joints: back pain, pain and muscle spasm.

Metabolism: hyperkalemia.

Uncommon, 1/1000

No information.

Rare, 1/10000

Systemic: Evaluation.

Eye: visual disorders.

Cardiovascular: tachycardia, reducing blood pressure or fainting (common in people with blood volume reduced or reduced salt, treatment with diuretics, especially in standing posture). digestive: stomach bleeding - intestines. DA: Ban, urticaria , itching.

Liver: Increased liver enzyme. blood: hemoglobin, neutrophils. Metabolism: hyperuricemia, hypercholesteroline blood cholesterol.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Telmisartan 40mg contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Pregnant women. Breastfeeding.

Severe kidney failure.

Severe liver failure. Bile.

Precautions when using

monitor blood potassium concentration, especially in the elderly and kidney failure. Reduce the starting dose in these patients.

Aortic valve stenosis or mitral valve.

Concerted hypertrophic cardiomyopathy.

Patients with severe congestive heart failure.

Patients are at risk of dehydration (decreased volume and sodium blood due to vomiting, diarrhea, prolonged use of diuretic, separation, salt restriction diet) increases the risk of symptoms. This disorder must be adjusted before using Telmisartan or reducing the dose and closely monitoring at the beginning of treatment.

Gastrointestinal ulcers - duodenum active or other stomach - intestinal disease (increased the risk of stomach - intestinal bleeding).

Mild and moderate liver failure.

Kidney artery stenosis.

Mild and medium renal function.

The ability to drive and operate machinery

Precautions when used for train drivers, operating machinery because the drug can cause dizziness, dizziness due to lower blood pressure.

Pregnancy

Be cautious when using Telmisartan for the first 3 months of pregnancy. Do not use for pregnant women from the 3rd month onwards.

Breastfeeding period

Not used for breastfeeding women.

Drug interaction

Digoxin : Concentition with Telmisartan increases serum Digoxin concentration, so it is necessary to monitor blood digoxin concentrations in the blood when starting to treat, adjust and stop Telmisartan to avoid the possibility of digoxin overdose.

Diuretic gums: increase the hypotension effect of telmisartan.

Warfarin : Time to simultaneously with Telmisartan for 10 days reduces the concentration of warfarin in the blood but does not change the INR.

Potassium diuretics: The supplement of potassium or use of other drugs that cause hyperkalemia may increase the effect of hyperkalemia of Telmisartan.

Storage

Store in a dry place, not more than 300C, avoid light.

Other drugs

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