Telmistal 40 Stallion treats hypertension (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Telmisartan

Ingredient

Composition information	Content
Telmisartan	40mg

Uses

indications

Telmistal 40 drugs are indicated in the following cases:

Treatment of hypertension in adults. Angiotensin II receptor (AT1 type) and oral activity. Telmisartan replaces Angiotensin II for a very high affinity at their position on the AT1 receptor mechanism, which is known to be responsible for the activity of Angiotensin II.

Angiotensin II does not show any partial activity in the AT1 receptor. Telmisartan mounted on AT1 receptors selectively. This cohesion usually lasts. Telmisartan usually has no affinity with other receptors, including AT2. The functional role of these receptors is not known nor does they know if they are too stimulating angiotensin II.

Plasma aldosteron levels decreased because of Telmisartan. Telmisartan does not inhibit human plasma renin or locked calcium channels. Telmisartan does not inhibit the enzyme (kininase II), the enzyme metabolizes Bradykinin. Therefore, there is no neutralization of unwanted effects of Bradykinin.

In humans, Telmisartan dose 80 mg completely inhibited Angiotensin II increased blood pressure. This inhibitor lasts 24 hours and can still be determined after 48 hours.

Pharmacokinetics

absorption

Telmisartan absorbs fast although the amount of absorption is very changing. Absolute average bioavailability of Telmisartan is about 50%. When Telmisartan is used with food, the area under the curve of the drug concentration over time decreases from 6% (dose of 40 mg) to nearly 19% (160 mg dose).

Distribution

Telmisartan is strongly attached to plasma proteins (> 99.5%), mainly albumin and alpha - 1 glycoprotein acid. The average apparent volume in a stable state (VDSS) is nearly the equal to 5001.

Metabolism

Telmisartan is determined by the exhaust dynamic dynamic of the exponent function with the semi -discharged time of> 20 hours. There is no clinical evidence related to the accumulation of Telmisartan at the recommended dose. Plasma concentration in women is higher than men, but does not affect efficiency.

After oral (and intravenous), Telmisartan is almost eliminated through feces, mainly in non -metabolic form. Kidney excretion accounts for less than 1% of the dose. Total plasma removal (CLTOT) (approximately 1000 ml/min) if compared to the rate of blood through the liver (about 1500 ml/min).

Before taking Telmistal 40 Stallion treats hypertension (3 blisters x 10 tablets)

How to use

Telmistal 40 drugs for oral.

Dosage

Dosage must be personalized. The starting dose is 40 mg once a day.

Some special patients: Patients with vascular volume reduced, patients with biliary obstruction disorders or liver failure using Telmisartan should be treated under the supervision of medical experts.

Most of the hypotension effect clearly that within two weeks and the maximum hypotension effect achieved after four weeks. Telmisartan can be increased by up to 80 mg once a day if necessary to achieve target blood pressure.

Do not use more than 40 mg/day in patients with mild and medium liver failure.

Children and teenagers: There is no data on the safety and effectiveness of Telmisartan in children and teenagers.

No initial dose adjustment for older patients or patients with renal impairment, including artificial dialysis. Patients with dialysis may have a standing hypotension, thus need to be closely monitored.

Telmisartan can be used with or without food.

Telmisartan can be used in combination with thiazid diuretics such as hydrochlorothiazid.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

The most prominent manifestation of Telmisartan overdose is hypotension and rapid vessels; Dizziness is slow, increased blood creatinine, acute renal failure is also reported.

Treatment

Telmisartan cannot be removed by fertilizer method. Patients should be tightly controlled, and symptomatic treatment should be treated. The main method depends on the time after taking the drug and the seriousness of symptoms. The recommended method is to cause vomiting or gastric lavage. Activated carbon can be useful in treating overdose. Serum and creatinine should be conducted regularly. If there is a hypotension, the patient should be on the back in combination with quick salt and fluid transmission.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Telmistal 40 you may experience unwanted effects (ADR).

Uncommon, 1/1000

Upper respiratory infections include pharyngitis infection, urinary tract infection including cystitis.

Anemia.

Hemorrhage.

depression, insomnia.

dizziness.

Slow rhythm.

Hypotension, hypotension.

Difficulty breathing.

Abdominal pain, diarrhea, indigestion, flatulence, vomiting.

Increase sweating, itching, skin rash.

Muscle pain, back pain (namely sciatica), muscle.

Renal failure includes acute renal failure.

Chest pain, weakness.

Hypertension of blood.

Rare, ADR

Small bloodshed.

Too hypersensitivity.

Axious. faint.

visual disorders.

tachycardia.

Stomach discomfort, dry mouth.

Extraordinary liver/liver function.

Red rash, angioedema, drug rash, skin toxicity, eczema.

joint pain, pain.

Tired like the flu.

hyperuricemia, hyper enzyme, increased creatin, blood phosphokinase, hemoglobin decrease.

Unknown frequency

Infections of death.

Incretion.

Anaphylaxis.

urticaria.

Ligament pain.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Telmistal 40 contraindications in the following cases:

Hypersensitivity to the ingredients of the drug.

Pregnant women.

Lactating women.

Severe kidney failure. Severe liver failure. biliary clogged.

Be cautious when using

liver failure

Telmisartan is not used for patients with biliary disorders or severe liver failure because Telmisartan is almost excreted by biliary tract. Telmisartan should be used carefully in patients with mild to moderate liver failure.

Aortic hypertension

Patients with 2 -sided kidney stenosis or artery stenosis to a functional area of the kidneys if treated with drugs that affect the Renin - Angiotensin - Aldosteron system will be an increase in the risk of serious hypotension and kidney damage.

kidney failure and kidney transplant

When using Telmisartan for patients with renal function, it is necessary to control potassium and blood creatinine levels periodically. Not much experience using Telmisartan on kidney transplant patients.

Reducing internal volume

Systemic hypotension, especially after using Telmisartan, the first dose may occur in patients with a decrease in volume or sodium ion for excessive diuretic, limited salt diet, diarrhea or vomiting. The above conditions may be treated before using Telmisartan.

Double blockade of Renin - Angiotensin - Aldosteron

The consequences of inhibiting the Renin - Angiotensin - Aldosteron, hypotension, unconsciousness due to hypotension, hyperboly, and renal function (including acute renal failure) have been reported in individual cases, especially if there is a combination with other drugs that also affect this system. Therefore, double blockade of the Renin - Angiotensin - Aldosterone (namely used enzyme inhibitors with Angiotensin II receptor antagonists) in patients who have controlled blood pressure levels and should be limited to use in patients to strictly control kidney function.

Other conditions stimulate the Renin - Angiotensin - Aldosteron system

In patients whose coronary artery status and renal function depend mainly on the activity of the Renin - Angiotensin - Aldosteron system (namely patients with severe congestive heart failure or kidney disease, including kidney artery stenosis), treated with drugs that affect this system such as Telmisartan is related to severe blood pressure lowering, hyperthyroidism, ureter, rare diameter.

Aortic stenosis or myocardial hypertrophic valve stenosis

As well as for other cardiovascular diseases, it is necessary to be especially cautious in patients with artery stenosis or myocardial hypertrophy.

Hyperbonia

Medicines on the Renin - Angiotensin system can cause hyperboly.

In the elderly or patients treated with many products and can cause increased blood potassium levels and/or patients who have recurrent recurrence, hyperkalemia can cause death.

Before deciding to simultaneously use drugs on the Renin - Angiotensin - Aldosteron system, it is necessary to evaluate the benefit ratio on risk.

It is necessary to strictly control the potassium level in plasma in patients at risk.

The ability to drive and operate machinery

There is no research on impact on the ability to drive and operate machinery. However, when operating the vehicle and driving machinery, it is possible to watch the problem of dizziness and drowsiness may occur when taking anti -hypertension drugs.

Pregnancy

If using this group of drugs from the second period of pregnancy, kidney and bone function should be checked. Needs to monitor babies with mothers using anti -receptor angiotensin II drugs.

The period of breastfeeding

There is no information and use Telmisartan during breastfeeding. Telmisartan is not recommended and should be changed to the use of drugs that are said to be safer.

Interactive drug

Lithium -containing drugs to treat some depression.

Medicines increase potassium levels such as potassium -replacement salts, potassium -saving diuretic, enzyme inhibitors, Angiotensin II receptor resistance, NSAIDs (such as aspirin or ibuprofen), heparin, dichotomic inhibitors (such as cyclosporin or tacrolimus) and trimethoprim antibiotic drugs.

Diuretics, especially if high doses with Telmisartan, can lead to dehydration in the body and low blood pressure.

As well as other antihypertensive drugs, Telmisartan's effectiveness can be reduced when used with NSAIDS or Corticosteroids.

Telmisartan may increase the effectiveness of hypotension of other hypertension drugs.

Storage

Store temperatures below 30 ° C, a cool dry place. Avoid light.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.