Tenadinir 300mg Medipharco medicine for infections is mild and medium (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Cefdinir

Ingredient

Composition information	Content
Cefdinir	300mg

Uses

Indications

Tenadinir 300 mg drug is indicated for use in the case of infection treatment at a mild and moderate level caused by sensitive bacterial strains.

Adults and children over 12 years:

Inrated pneumonia from the community caused by the strains of Haemophilus influenzae, Haemophilus parainfluenzae, Streptococcus pneumoniae, Moraxiella Catatrhalis. Streptococcus Pneumoniae and Moraxiella Catnrhalis.

Sore throat/tonsillitis is caused by streptococcus pyogenes strains.

Dermatitis and uncomplicated soft tissue caused by staphylococcus aureus and streptococcus pyogenes.

Pharmacokological

The mechanism of action of CEFDinir is to inhibit the synthesis of bacteria walls.

Cefdinir has a broad spectral activity against Gram -positive and gram -negative microorganisms. Cefdinir works most in the strains of bacteria in vitro and clinically such as: Aerobic Gram -positive bacteria, including: Staphylococcus aureus (including seminarians Betalactamase), Streptococcus pneumoniae (penicilin -sensitive strain), Streptococcus pyogenes.

Aerobic gram-negative bacteria, including: Haemophilus influenzae, Haemophilus parainfluenzae and moraxella catrhalis (including beta-lactamase seminarians).

Cefdinir does not work on Pseudomonas, Entrobacter Species, Staphylococci resistant methicilin and anaerobic bacteria.

pharmacokinetic

absorption

CEFDINIR's peak plasma concentration is achieved within 2-4 hours after drinking. Foods containing high fat content will reduce the absorption capacity of the drug from 16% to 10%. So do not use cefdinir with food.

Distribution

The average distribution of CEFDinir in adults is 0.35 l/kg. 60 - 70% CEFDINIR bound with plasma, this cohesion regardless of concentration. Cefdinir can be distributed into phlegm, tonsils, sinus jaws, mucous membranes, ear production, tissue in the mouth. Cefdinir does not see breast milk.

Metabolism

Cefdinir is not metabolized.

Elimination

Cefdinir is excreted mainly through the kidney with half -life of semi -excreted life of 1.7 hours. Cefdinir clearance in patients with renal function.

Before taking Tenadinir 300mg Medipharco medicine for infections is mild and medium (2 blisters x 10 tablets)

How to use

Tenadinir 300 mg is taken orally. Do not drink with food.

Dosage

Dosage for all infections is 600mg/time/day and treatment within 10 days. There is no study of a daily dose for people with pneumonia and skin. So only drink 2 times/day in these patients.

adults and children over 12 years old

Pneumonia is suffering from the community

300 mg every 12 hours, for 10 days.

Heavy chronic pneumonia

300 mg every 12 hours or 600 mg every 24 hours, for 10 days.

Sinusitis

300 mg every 12 hours or 600 mg every 24 hours, for 10 days.

Sore throat/tonsillitis

300 mg every 12 hours or 600 mg every 24 hours, for 5 or 10 days.

Dermatitis and soft tissue without complications

300 mg every 12 hours, for 10 days.

Patients with renal failure

Adults

Creatinine clearance

Pediatric patients

Creatinine clearance

Patients with hemorrhage

Due to the hemorrhage excretion of cefdinir from the body, for patients with chronic juris, the starting dose is 300 mg or a dose of 7 mg/kg every two days. After each hemorrhage use 1 dose 300 mg or 7 mg/kg/day, every two days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Signs and symptoms of poisoning after overdose with other beta lactam antibiotics include: nausea, vomiting, epigastric pain, outside and convulsions.

Cefdinir can be removed from the body through hemorrhage. In case of severe poisoning due to overdose, hemorrhage can help eliminate Cefdinir from the body. That may be useful in case of severe poisoning due to overdose use, especially if the renal function is impaired.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Tenadinir 300 mg you may experience unwanted effects (ADR).

Unknown frequency

Disorders in the gastrointestinal tract: diarrhea, abdominal pain, serious colitis, colitis with fake membranes manifested by blood stools.

nervous: Stun.

Anaphylactic reaction: may encounter anaphylactic reactions (shortness of breath, spreading burning, angioedema, urticaria).

Skin disorders: Stevens -Johnson syndrome, Lyell syndrome.

Hematology disorders: All -blood cell reduction, grain leukemia, thrombocytopenia.

pneumonia: pneumonia or pie syndrome.

Hepatitis: Sudden hepatitis, liver or jaundice disorder.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Tenadinir 300 mg drug is contraindicated in the following cases:

Patients with allergies to antibiotics of cephalosporin or any ingredients of the drug.

Do not use drugs for children under 6 months old.

Precautions when using

people with a history of hypersensitivity to the penicillin group.

Personal or family tendencies have allergic reactions, such as bronchial asthma, rash or urticaria.

People with severe kidney disorders. Dosage should be reduced in patients with impaired or long -term renal function (Creatinine clearance

Patients who do not nourish oral, or patients need to be nourished by vein, or maybe depression (cefdinir may reduce prothrombin time, so meticulously monitoring in these subjects can develop symptoms of vitamin K deficiency).

Elderly patients: When using this drug for elderly patients, the dose and dosage should be adjusted, based on the clinical comments on the patient's state.

When suspected or uncertain about infections or prevention indications, patients should not take the drug as it may increase the risk of developing bacteria against drugs.

As well as antibiotics with wide antibacterial spectrum, prolonged treatment can lead to the development of antibacterial strains. Must monitor patients carefully if necessary.

If poisoning occurs during treatment, there should be appropriate supportive therapies.

Cefdinir should be used cautiously with patients with a history of colitis.

stool tinged with redness when drinking Cefdinir and iron -containing preparations such as powdered milk or drinking with nutrients. Can encounter a slightly red urine.

The ability to drive and operate machinery

There is no full study of the effect of the drug on the ability to drive and operate machinery. However, when using the drug may experience stunning, dizziness, tinnitus should avoid driving or operating machinery if this symptom appears.

Pregnancy

There is no adequate and controlled study in pregnant women. Only use Cefdinir during pregnancy when really necessary.

Breastfeeding period

After using a single dose of 600 mg, Cefdinir is not detected in breast milk. However, you should still be cautious when used for breastfeeding women, only used when really necessary.

Medicinal interaction

Antacids (containing aluminum or magnesium) simultaneously cefdinir with drugs containing aluminum or magnesium reduces CEFDINIR absorption. If Antacid is really necessary during treatment, it is necessary to take cefdinir before or after at least 2 hours to take antacids.

Probenecid: As well as other β-lactam antibiotics, Probenecid inhibits the renal elimination for Cefdinir.

Iron supplements and iron -containing foods: Cefdinir simultaneous use with iron -containing substances or will reduce Cefdinir absorption. If you really need to add iron during the treatment, then you need to take Cefdinir at least before or after 2 hours.

Storage

Store in a cool dry place, at temperatures below 30 ° C, avoiding light.

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