TENFOVIX medicine for HIV infection, hepatitis B (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Tenofovir disoproxil fumarate

Ingredient

Composition information	Content
Tenofovir disoproxil fumarate	300mg

Uses

indications

TENFOVIX drug is indicated in the following cases:

Coordinate with other antiviral drugs to treat HIV infection. Tenofovir Disoproxil Fumarate Hydrolyzed Diester Based to form Tenofovir. After that, Tenofovir was transformed by the enzymes of the cell into tenofovir diphosphate.

Tenofovir Diphosphate inhibits the activity of HIV -1 by competing directly with the natural substrate of Deoxyadenosine 5 -triphosphate, and then, merged into the virus's DNA DNA to end the AND end. Tenofovir diphosphate inhibits DNA polymerase α, β and polymerase DNA mitochondrial.

pharmacokinetics

Oral bioavailability is about 25%.

In people with HIV-1 infected, after taking the dose of Tenotovir disoproxil tumarat 300mg, CMAX is achieved after 1.0 ± 0.4 hours. CMAX, AUC of Tenotovir are 296 ± 90 ng/ml and 2287 ± 685 ng.hr/ml. Food has an effect on CMAX of Tenofovir about 1 hour.

In vitro, about 7.2% associated with human serum protein.

Tenotovir's sale time is about 17 hours. Tenofovir is excreted through the kidneys thanks to the combination of glomerular filtration and active excretion through the renal tubules.

Before taking TENFOVIX medicine for HIV infection, hepatitis B (3 blisters x 10 tablets)

How to use

Tennfovix medicine for oral use.

Dosage

Adults: 1 capsule (300 mg) x 1 time/day.

Patients with renal failure

Creatinine clearance (ml/minute)

≥ 50

30 - 49

10 - 29

1 tablet (300 mg) every 24 hours

1 tablet (300 mg) every 48 hours

1 tablet (300 mg) every 2 times/week.

Every 7 days or after a 12 -hour separation.

Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? In healthy subjects, Tenofovir Disoproxil Fumarate dose 600mg in 28 days, no complications occur.

If there is an overdose of the drug, the patient must be monitored to see if there is any manifestation of poisoning, and if necessary, it is possible to apply supportive treatments.

After using Tenofovir Disoproxil Fumarate 300mg Single dose, a hemorrhage jury within 4 hours has eliminated about 10% Tenofovir.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Tenfovix, you may experience unwanted effects (ADR).

Common

Agent to medium-sized stomach disorders such as anorexia, abdominal pain, diarrhea, indigestion, flatulence, vomiting and nausea. In addition, it is possible to experience dizziness, fatigue, headache, skin rash, reduced blood phosphate.

rarely

Increased plasma amylase levels, pancreatitis, increased liver enzyme, hepatitis; Kidney toxicity includes: fanconi syndrome, interstitial nephritis, and acute renal failure; Lactic acid infections are often accompanied by liver and fatty liver hypertrophy.

The effect of reducing the density of minerals in the bone is recorded in patients with HIV infected with a history of fracture or have risk factors for osteoporosis or bone loss.

Cases of accumulation of fat, metabolic abnormalities such as hyperglyceride, hypercholesterolemia, insulin resistance, hyperglycemia or increased creatine phosphokinase, muscle pain, muscleitis have also been reported.

Instructions on how to handle ADR

Notice the unwanted physician when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

TENFOVIX drug is contraindicated in the following cases:

Patients with hypersensitivity to the ingredients of the drug.

Lactating women.

Be cautious when using

Lactic acid infection/Liver hypertrophy and fatty liver

Lactic acidosis, liver and fatty liver hypertrophy (including death), have been reported when using nucleoside similar substances including tenofovir in combination with other antiretroviral drugs. Most cases occur in women. In which obesity and exposure to long -lasting nucleoside are risk factors. Therefore, it is necessary to be careful when using the drug in patients with risk factors for liver disease.

The use of the drug should be suspended if there is an increase in the concentration of aminotransferase, lactic acidic acidosis, or showing signs of toxic liver (including liver hypertrophy and fatty liver even in the absence of a significant increase in transaminase).

Patients with renal failure

Be cautious about monitoring kidney function, especially in patients at risk or have a history of renal dysfunction, to detect changes in creatinine and serum phosphate.

Patients with HIV -infected and hepatitis B virus

Patients infected with HIV virus should check for hepatitis before conducting Retrovirus resistance. Tenotovir is not indicated in the hepatitis B. The effect and safety of Tenotovir has not been proven in HIV -infected patients and hepatitis B virus B. Some reports show that there is a severe hepatitis B.

Other caution

Children

should only take the drug during pregnancy when it is really necessary and after careful consideration of the risks and benefits of the drug.

The ability to drive and operate machinery

Tenofovir disoproxil fumarat can cause dizziness. If you feel dizzy when taking the drug, do not drive and operate machinery.

Pregnancy

There has been no complete research on the use of drugs in pregnant women. The drug should only be used during pregnancy when it is really necessary and after careful consideration of the risks and benefits of the drug.

Lactation period

Contraindications for breastfeeding women.

Medicinal interaction

Tenofovir concurrence with drugs that reduce kidney function or drugs compete with Tenofovir to be discharged in the renal tubules can increase the serum concentration of tenofovir or shared drugs.

Tenofovir simultaneous use with Atazanavir, Lopinavir, Ritonavir may increase the concentration of tenofovir.

Storage

In a dry, cool place (below 30 ° C), avoid light.

Other drugs

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