Terbutalin Sulfat Guaifenesin Olexon S Ha Nam solution for coughing cough, cough due to bronchial asthma (90ml)

Dosage form Jar
Specifications Terbutalin sulfate, Guifenesin

Ingredient

Thành phần cho 5ml

Composition informationContent
Terbutalin sulfate1.5mg
Guiifenesin66.5mg

Uses

Indications

Oral solution of Oxon S indicated in the following cases: cough with phlegm, cough due to bronchial asthma, bronchitis, puncture gas and other lung diseases that cause bronchospasm and increase secretion.

Pharmacokology

terbutalin sulfate

Pharmacological group: bronchodilators, reducing uterine contractions, selected Beta2 selection owners

ATC: R03CC53

Terbutalin sulfate is a sympathetic nerve synthetic amino, a beta2 -adrenergic agreement, which stimulates the beta receptor of the sympathetic nervous system, has no effect on the alpha receptor. The main effect of Terbutalin is to relax the bronchial smooth muscles, uterus and peripheral circuits. The drug reduces the respiratory resistance, so it increases exertion in 1 second (FEV1: Forced Expiratory Volume in One Second). Terbutalin does not directly change the artery oxygen pressure. The drug stimulates the production of adenosin-3'5'5'-Monophosphate (AMPC) due to the activation of the adenyl cyclase enzyme.

Like metaproterenol and albuterol, terbutalin has a strong stimulating effect on the beta2 receptor of the bronchi, uterine smooth muscle, blood vessels and very little effect on the beta2 receptor of the heart. However, at high doses, Terbutalin may cause heart and central nervous system. Terbutalin sometimes increases the heart rate, but it is unclear, it is due to the Terbutalin stimulating the beta2 receptor or due to reflex response with changes in blood pressure due to peripheral vasodilation.

GuaiFenesin

Pharmacological group: Drugs for phlegm

ATC: R05CA03

Guaifenesin has a sputum effect by irritating the gastric mucosa, then stimulating increasing secretion in the respiratory tract, increasing the vol

As a result, the drug increases the effectiveness of cough reflexes and makes it easier to expel phlegm. This mechanism is different from the mechanism of anti -cough drugs, it does not lose cough reflexes. The drug is indicated to treat symptoms of cough with thick sputum difficult to cough due to colds, mild upper respiratory tract. The drug is often combined with bronchodilators, nasal congestion, antihistamine or anti -cough drugs.

pharmacokinetics

terbutalin

absorption

About 30-50% of terbutalin sulfate oral dose is absorbed through the gastrointestinal tract. After drinking, the breathing effect appears within 30 minutes, the lung function is improved in the clinical nature after 1-2 hours, reaching the maximum within 2-3 hours and the effect time lasts 4-8 hours. Half life of the drug is about 3-4 hours.

Distribution

Terbutalin is distributed into breast milk at the least concentration equal to plasma concentrations at the same time. However, the amount of drug in milk is not equal to 1% of the mother's oral dose.

Metabolism and elimination

Terbutalin is partially metabolized in the liver, mainly into substances associated with sulfuric acid that is no longer active. When taken, most of the dose is eliminated in the form of a complex substance. This indicates that the drug may be metabolized in the digestive tract, or initially metabolized through the liver. The elimination of drugs and metabolites completed within 72 - 96 hours after taking a dose of oral. After taking single dose in patients with asthma, half -life eliminates about 3.4 hours.

GuaiFenesin

After drinking, the drug absorbs well from the digestive tract. In the blood, 60% of the drug is hydrolyzed for 7 hours. The metabolites are no longer active and excreted through the kidneys. After taking 400 mg of guaifenesin, no drug is not detected in the intact form in the urine. Half of the lifetime of Guaifenesin about 1 hour.

Before taking Terbutalin Sulfat Guaifenesin Olexon S Ha Nam solution for coughing cough, cough due to bronchial asthma (90ml)

How to use

Oral solution Oxon S is directly drinking, can be diluted with water or drink water after use.

Dosage

Adults:

  • Take 10 - 15 ml (2 - 3 teaspoons) x 2-3 times/day.

    • Children:

  • 7 - 15 years old: 5 - 10 ml (1 - 2 teaspoons) x 2-3 times/day. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

    Symptoms and possible signs:

  • headache, anxiety, tremor, cramps, suspense, arrhythmia. Sometimes hypotension. Beta2 motorbikes can cause hypokalemia due to potassium re -distribution, but often do not need treatment.

    • Handling:

    a) Mild to medium case: reduce the dose. Then increase the dose slower if it has not been effective against spasms.

    b) Severe case:

  • Stomach, activated carbon. Check the balance of acidic alkaline, blood sugar and electrolytes. Monitor frequency, heart rate, blood pressure. It is necessary to promptly adjust the changes in metabolic. If the peripheral resistance via the beta2 receptor contributes significantly to hypotension, the plasma volume is needed.

    What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

    • Side Effects

    The intensity of adverse reactions depends on the dose and usage.

    The following terms are used to classify adverse reactions based on frequency:

  • Very common: ≥1/10;
  • Common: ≥1/100 and

    Terbutalin

    Common

  • Cardiovascular: increased heart rate, changing blood pressure, brushing chest drums.
  • Neurology: headache, nausea, vomiting; restlessness, difficulty sleeping, or sleeping, sleeping chicken; weak people; hot face, sweating, chest tightness, muscles, tinnitus.
  • Neurological: convulsions, hypersensitivity.

    Rare or rare reactions: dizziness, headache, diarrhea, vomiting or nausea, abdominal pain, skin rash, urticaria. Kidney stones have been reported in patients who abuse the preparation containing Guaifenesin.

    Treatment: Stop taking the drug if vomiting and abdominal pain are much. Avoid prolonged medication.

    Notify the physician the unwanted effects when using the drug.

    • Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Oral solution of Oxon S contraindicated in the following cases:

  • Patients with hypersensitivity to any ingredients of the drug.

    • Be cautious when using

    use caution in the case of increased sensitivity to sympathetic amines, such as untreated patients with thyroid poisoning.

    Need to monitor more blood sugar tests for asthma patients and have diabetes at the same time when they start treatment, due to the risk of hyperglycemia by beta2 transportation drugs.

    Beta2 transport owners have been successfully used in the treatment of emergency heart failure due to severe ischemia. However, these drugs are likely to cause arrhythmia, so it is necessary to consider treatment for each patient with lung disease.

    Due to the stimulating effects of myocardial contraction of Beta2, this drug should not be used in patients with hypertrophic cardiomyopathy.

    Hypotension can occur when using Beta2 agonized drugs simultaneously with the derivatives of xanthin, steroids, diuretics or due to hypoxia. So need to monitor blood potassium in these cases.

    Note that this drug may have a positive reaction when doing anti -doping tests.

    consult your doctor before use if there is a condition without tolerance.

    Use drugs for women during pregnancy and lactation

    recommendations not for pregnant women.

    Only for women who are breastfeeding when benefits are superior to risks.

    The effect of the drug on driving and operating machinery

    does not have enough evidence to act on the ability to drive and operate machinery. Be cautious when driving and operating machinery.

    Drug interaction

    terbutalin

    With sympathetic stimulants:

    Terbutalin is not used simultaneously with sympathetic stimulants, as the ability to increase the complications on the cardiovascular system. However, the aerosole bronchodilator type irritates adrenergic (bronchiectasis), which can be used, reducing acute bronchospasm in patients who are taking long oral terbutalin.

    With the conduction of theophylin:

    There is evidence thanks to animal studies showing simultaneous use of sympathetic stimulants (including terbutalin) and theoophylin derivatives such as aminophylin, which can increase the toxicity on the heart, such as arousing.

    Mao inhibitors or 3 -round antidepressants increase the harmful effects on the cardiovascular system when combined with Terbutalin. Therefore, when it is necessary to coordinate, must be very careful.

    GuaiFenesin

    Interactive drugs: Do not use Guaifenesin combination preparations with dextromethorphan for patients who are taking Mao inhibitors.

    Be careful when using the coordination products of Guaifenesin and Phenylpropanolamine for patients with hypertension, heart disease, diabetes or peripheral patients, prostate hypertrophy and glaucoma.

    Storage

    Leave a cool place, avoid light, temperature below 30⁰C.

    Other drugs

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