Tetracyclin 500mg Uphace treatment for respiratory infections (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Tetracycline

Ingredient

Composition information	Content
Tetracycline	500mg

Uses

indications

Tetracyclin is indicated in the following cases:

Upper respiratory infections caused by Streptococcus Pyogenes, Streptococcus Pneumoniae, Haemophilus Influenzae.

Lower respiratory infections due to streptococcus pyogenes, streptococcus pneumoniae, Mycoplasma pneumoniae.

Skin infections and soft tissue due to streptococcus pyogenes, Staphylococcus aureus.

Infections caused by Rickettsia, Chlamydia Trachomatis (Urethritis, cervix or uncomplicated rectum), Campylobacter fetus.

Diseases caused by Chlamydophila Psittaci, Klebsiella Granulomatis (granuloma), Borrelia sp. (Fever), Bartonella Bacilliformis (soft orange), Francisella Tularensis (Lymphoma), Yersinia Pestis (Plague), Vibrio Cholerae (Dichon) Brucella, Entamoeba Histolytica (amoeba dysentery).

Urinary tract infections caused by Escherichia Coli strains, Klebsiella, ...

Other infections caused by sensitive Gram -negative bacteria such as E. coli, Entrocter Aerogenes, Shigella SP., Acinetobacter sp., Klebsiella sp., and Bacteroides sp.

In severe acne, tetracyclin can be used.

When contraindicated to penicillin, tetracyclin is a replacement drug in the treatment of the following infection symptoms: Syphilis and scabies caused by treponema pallidum and pertenue; Fusobacterium fusiforme infection; Infections caused by Neisseria Gonorrhoeae, anthropomic due to Bacillus anthracis; infections caused by listeria monocytogenes; infection of Actinomyces species; Infections caused by clostridium species.

Pharmacy

Tetracyclin is a broad -spectrum antibiotic that has the effect of bacteria due to inhibiting bacterial protein synthesis. The mechanism of action of tetracycline is due to the ability to attach and inhibit the ribosom function of bacteria.

When entering the bacterial cell, Tetracyclin is attached to the 30s subunit of ribosom, separating the aminoacyl trna cohesion that inhibits protein synthesis. When tetracyclin resistant bacteria, the position of tetracycline on ribosom is changed, so tetracycline is not attached to the ribosom of bacteria and ineffective.

pharmacokinetics

absorption:

Tetracyclin is absorbed through the digestive tract, about 80% tetracyclin is absorbed when taking the drug when hungry. Tetracycline absorption decreases when there is a valence metallic ionic ion 2 and 3 due to sustainable insoluble complexes. In addition, the absorption of tetracyclin when wasted is also affected by milk and food.

Distribution:

Tetracyclin is widely distributed in tissues and fluid fluids. The concentration in cerebrospinal fluid is relatively low, but may increase in the case of meningitis. A small amount appears in saliva, tears and lung fluid.

Tetracyclin is also found in breast milk with a concentration that can reach 60% or more than the concentration of drugs in the mother's blood. Tetracyclin through the placenta and appears in the fetal circulation with the heat of about 25 - 75% compared to the concentration of drugs in the mother's blood.

tetracyclin attaches to the bone during the new bone formation, calcification process and affects the formation of children's bones and teeth.

Metabolism and elimination:

The half -life of Tetracyclin is about 8 hours, 55% of oral doses are eliminated through urine in unproperated form. In addition, the drug is also excreted through the bile into the intestine and partly re -absorbed through the hepatic circulatory round.

Before taking Tetracyclin 500mg Uphace treatment for respiratory infections (10 blisters x 10 tablets)

How to use

Take the medicine at least 1 hour before or 2 hours after meals or after drinking milk.

To avoid irritation of the esophagus, tetracyclin should be taken with plenty of water in a straight position, should not be lying immediately after taking the medication, do not take the medicine before going to bed.

Dosage

adults:

Common dose: 1 g/day, drink 500 mg x 2 times/day (1 tablet x2 times/day).

Cases of severe infections or cases of infections that do not respond to small doses: oral 500 mg x 4 times/day (1 tablet x 4 times/day).

Streptococcus infection. Treatment time should continue for 10 days.

Brucellosis:

Tetracyclin 500 mg x 4 times/day (1 capsule 4 times/day), used for 3 weeks.

Early syphilis (less than 1 year) 500 mg 4 times/day (1 tablet x 4 times/day), for 15 days.

Dosage recommended 500 mg 4 times/day (1 tablet x 4 times/day), for 7 days.

Take 500 mg x 4 times/day (1 tablet x 4 times/day), at least 7 days.

According to the diagnosis of a clinical doctor, long -term treatment, the recommended starting dose is 1000 mg/day divided into several times. Age:

Take 25 - 50 mg/kg body weight/day, divided 4 times.

used on special subjects:

In patients with renal failure, it is recommended to reduce the total dose by reducing the dose and/or increasing the distance between use.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

How to handle:

Currently there is no specific antidote. Mainly symptomatic treatment:

Measures to cause vomiting and stimulation.

Control hypersensitivity reactions.

For regular or prolonged convulsions, the diazepam or lorazepam intravenous injection is required.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using tetracyclin , you may experience unwanted effects (ADR).

Rare (1/10,000

Blood disorders and lymphatic systems: hemolytic anemia, thrombocytopenia, neutropenalia, eosinophilia, leukopenia, anemia do not regenerate.

Gastrointestinal disorders: Difficulty swallowing, esophagitis and esophageal ulcer.

Biliary disorders: Temporarily increase the results of liver function tests, hepatitis, jaundice, liver failure.

Kidney and urinary disorders: acute renal failure , renal inflammation.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Tetracyclin contraindicated in the following cases:

Sensitive people with any drugs of Tetracyclin;

Pregnant and lactating women;

Children under 8 years old;

Severe renal function; chronic liver failure;

Systemic lupus erythematosus;

Do not share tetracyclin and vitamin A or retinoids due to the risk of increased intracranial pressure.

Be cautious when using

tetracyclin can cause excessive growth of unsure microorganisms, including mushrooms. If the infection occurs, it is necessary to stop the drug and replace it with another appropriate regimen.

When long -term treatment, periodic tests are required to evaluate liver, kidney and hemorrhage.

Light sensitivity: Patients who use tetracyclin if exposed to direct sunlight or ultraviolet rays should be warned about this risk and need to stop the drug as soon as the first symptom of the Red Red Red

Dental development: The use of tetracyclin drugs in the stage of tooth development (the second half of pregnancy and children under 12 years old) can cause permanent teeth discoloration (yellow, gray, brown) and the drug can be attached and affect bone growth.

The ability to drive and operate machinery

There is no information on the effect of the drug on the ability to drive, operate machinery

Pregnancy

The use of tetracyclin in and near pregnancy will cause the following consequences: Harm to the teeth and bone, tetracycline hepatitis in pregnant women, causing congenital malformations.

Contraindicated for pregnant women. Only use tetracyclin for pregnant women when really necessary.

breastfeeding period

tetracyclin distributed in breast milk. Although tetracyclin can be created with calcium in breast milk into unapproachable complexes, it should not be used during breastfeeding due to permanent teeth discoloration, reducing enamel, inhibiting bone growth, light sensitive reactions and candidiasis in the mouth and vagina.

Therefore, mothers should consider not using tetracyclin or not breastfeeding when taking this medication.

Drug interaction

tetracyclin + Penicilin: Tetracyclin reduces penicillin activity in the treatment of meningitis caused by pneumococcal.

tetracyclin + antacids: When used with antacids containing aluminum, bismuth, calcium or magnesi, plasma tetracyclin levels decrease, leading to significant or completely loss of antibiotic activity. Other antacids such as sodium bicarbonate increases gastric pH can also reduce the bioavailability of tetracyclin. tetracyclin + Diuretics: This interaction leads to hyperemia. tetracyclin + iron -containing preparations: significantly reducing the absorption of both of these drugs in the intestine, leading to a decrease in serum concentration, reduced or lost treatment effect. If it is required to use both of these drugs, the time to drink them must be as long as possible to avoid mixing these two drugs in the intestine.
tetracyclin + Milk and dairy products: Tetracyclin absorption is significantly reduced (70 - 80%) if used in the same milk and dairy products, resulting in reduced or lost treatment.
tetracyclin + anticoagulant: Tetracyclin reduces the activity of plasma prothrombin, so the patient is being treated with anticoagulants can adjust the anticoagulant dose.
tetracycline + methoxyflurane: reported to be toxic to the kidneys.

tetracyclin + contraceptive pills: can be used in effective oral contraceptive pills.

Storage

Tetracyclin 500 mg stiff capsules in a dry place, avoiding light, temperatures not exceeding 30 degrees C.

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