Tetracyclin 500mg Vidipha treatment for infection (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Tetracycline

Ingredient

Composition information	Content
Tetracycline	500mg

Uses

indications

Tetracyclin 500mg drugs are indicated in the following cases:

Chlamydia infections;

nicolas favre disease; Pneumonia, bronchitis or sinusitis caused by chlamydia pneumoniae, parrot fever (psittacosis); trachoma; Non -specific urethritis caused by Chlamydia Trachomatis;

Rickettsia infections; Description (by Vibrio Cholerae);

acne;

should only use tetracyclin when proving that bacteria are still sensitive. Due to the serious level of resistance of bacteria and due to many other antibacterial drugs, it is necessary to limit the use of tetracyclin. However, the drug still has some indications as above.

Pharmacokology

Mechanism of action:

Tetracyclin is a broad -spectrum antibiotic that has the effect of bacteria due to inhibiting bacterial protein synthesis. Therefore, tetracyclin prevents aminoelyl - RNA attachment leading to inhibition of protein synthesis. When tetracyclin resistant bacteria, the position of tetracycline on ribosom is transformed. Therefore, Tetracyclin cannot be attached to the bacterial ribosom and ineffective. The drug also works on Chlamydia, Mycoplasma, Rickettsia, Spirochochete, Mushroom, Yeast, Virus that are not sensitive to Tetracyclin.

Drug resistance:

All tetracyclin has a very important common property, which is to use a lot that always leads to drug resistance. In Vietnam, the abuse of Tetracyclin has led to wide resistance, reducing or losing effects of the drug.

For bacterial bridges: It is estimated that more than 50% of Staphylococcus strains, over 50% of streptococcus strains (especially over 60% of strains strains.

For Gram -negative bacilli: estimated over 40% of Haemophilus Influenzae, over 80% of the Klebsiella strains, E.Aerogenes, Shigella Flexneri, E.coli are all resistant to tetracyclin. All pseudomonas, Proteus, Serratia strains are also resistant to drugs.

According to ASTS data in 1997: In Vietnam, 92.9% Salmonella Typhi resisted tetracyclin, 41.4% H.influenzae, 87.9% K.Pneumoniae, 82.9% E.Aerogenes, 86.7% Shigella Flexneri, 57.1% Staphyloccus Aurus, 82% E.coli, 50% Streptococcus Pyogenes, 79.2% Streptococcus Group D has been resistant to DOXYCYCLIN, which means they also resisted tetracyclin.

Dynamic pharmacokinetics

absorption:

Tetracyclin is absorbed through the gastrointestinal tract. Taking drugs when hungry about 80% tetracyclin is absorbed.

Tetracycline absorption is reduced if there is a metal ions 2 and 3 due to sustainable insoluble complex. In addition, oral tetracyclin absorption is also affected by milk and food.

Distribution:

1 hour after taking a single dose of 250 mg, the drug reaches a plasma treatment concentration (over 1 mcg/ml). The maximum concentration of 2-3 mcg/ml is achieved after 2-3 hours, and the treatment concentration is maintained for about 6 hours. The concentration in cerebrospinal fluid is relatively low, but may increase in the case of meningitis. A small amount appears in saliva, tears and pulmonary fluid. Tetracyclin through the placenta and appears in the fetal circulation at a concentration of 25-75% compared to the concentration of drugs in the mother's blood. Tetracyclin attaches to the bone in the process of creating a new bone, calcification process and affecting the bone formation of bones and young teeth.

Elimination:

Half of the lifetime of tetracyclin is 8 hours, 55% of oral doses are discharged through urine in unproperated form. The concentration of tetracyclin in the urine can reach 300 mcg/ml after taking a normal dose of 2 hours and maintain within 12 hours.

Before taking Tetracyclin 500mg Vidipha treatment for infection (10 blisters x 10 tablets)

How to use

Take oral use, should drink 1 hour before or 2 hours after eating.

To avoid irritation of the esophagus should drink with plenty of water in a standing position, patients should not lie down immediately after taking the drug.

Dosage

Often used:

Adults: 500 mg, every 6 hours.

Children over 8 years old: 25 - 50 mg/kg body weight, divided daily 2-4 times.

In case of kidney failure, but if necessary, the dose must be reduced.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Tetracyclin 500mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100:

Digestive: Nausea, vomiting, diarrhea.

Metabolic: underdeveloped teeth and discoloration when using tetracyclin for pregnant women and children under 8 years old.

Other reactions: Increased antibiotic development bacteria and the risk of developing antibiotic -resistant intestinal bacteria.

Uncommon, 1/1000

Digestive: ulcers and esophagus narrowing.

Skin: skin allergic reaction, urticaria, edema, increased sensitivity to light when in direct contact with the sun.

Rare, ADR

Systemic body: Answer hypersensitivity reactions, anaphylactic bleeding, perinouretic inflammation, lupus erythematosus.

blood: Hemolytic anemia, thrombocytopenia, neutropenia and eosinophilic hypernagus. digestive: fake colitis, tongue, stomatitis, pancreatitis. gynecological: cervicitis, vaginitis, fungal infections due to permanent bacterial bacterial disorders.

Liver: Poisoning with liver along with renal function. Neurology: Hurry increased intracranial pressure.

Instructions on how to handle ADR:

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Tetracyclin 500mg contraindications in the following cases:

Sensitive to any tetracyclin.

Pregnant women and children under 6 years old.

Be cautious when using

may occur in superinfection.

When treated for prolonged treatment, it is necessary to perform periodic tests to evaluate liver, kidney and hematurian function.

The risk of a sensitive reaction to light manifests by sunburn when exposed to sunlight.

The ability to drive and operate machinery

No report.

Pregnancy

Do not use Tetracyclin antibiotics for pregnant women, the use of tetracyclin in and near pregnancy will cause harm to the teeth and fetal bones, the liver of the pregnant person, causing congenital deformities and other harmful effects.

breastfeeding period

tetracyclin distributed in breast milk. Although tetracyclin can be created with calcium in breast milk with unapproached complexes, it is not advisable to use tetracyclin during breastfeeding because of the ability to cause permanent teeth, reduce enamel, inhibit bone growth, light sensitive reactions and candidiasis in the mouth and vagina.

Drug interaction

Tetracyclin reduces penicillin activity in the treatment of meningitis caused by pneumococcal and may also be pink.

The effect of tetracyclin is reduced if used with anti -acid drugs containing aluminum, bismut, calcium or magnesium.

Collaborate with diuretics causing hyperur with hyperur.

Coordinate with iron -containing preparations to reduce or lose the treatment effect of both drugs. If required to use both of these drugs, drink apart as long as possible.

Absorbing tetracyclin significantly (up to 70 - 80%) if used in the same milk and dairy products, leading to reduction or loss of treatment ability.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

Other drugs

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