Tetracyclin TW3 500mg Treatment of infections, plague (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Tetracyclin

Ingredient

Composition information	Content
Tetracyclin	500mg

Uses

Indications

Tetracyclin 500 mg TW3 is indicated in the following cases:

Treat the infections caused by Rickettsia, Mycoplasma, plague, cholera, trachoma, acne, pneumonia, bronchitis or sinusitis caused by chlamydia, Brucella disease. The mechanism of action of tetracycline is due to the ability to attach and inhibit the ribosom function of bacteria, especially attached to the 30S unit of ribosom. Therefore, tetracyclin prevents the process of attaching aminoelyl t - RNA leading to inhibition of protein synthesis. When tetracyclin resistant bacteria, the position of tetracycline on ribosom is transformed. Therefore, tetracycline is not attached to the ribosom of bacteria and ineffective.

Tetracyclin works on many bacteria that cause both gram -negative and gram -positive bacteria, both aerobic and anaerobic. The drug also works on Chlamydia, Mycoplasma, Risketsia, Spirochochete.

drug resistance

all tetracyclin has a very important common property, which is to use a lot that always leads to drug resistance.

So far, there are many strains of bacteria that have been resistant to tetracyclin due to unreasonable drug abuse, especially in Vietnam.

For bacterial bridges: It is estimated that more than 50% of Staphylococcus strains, over 50% of streptococcus strains (especially over 60% of Str.Pneumoniae) are resistant to tetracyclin. For Gram -negative bacilli: estimated over 40% of Haemophilus Influenzae, over 80% of Klebsiella, E.Aerogenes, Shigella Flexneri, E.coli are all resistant to tetracyclin. All Pseudomonas, Proteus Serratia strains are also resistant. Therefore, Tetracyclin is currently rarely used or used but ineffective.

Pharmacokinetics

absorption

Tetracyclin is absorbed through the gastrointestinal tract.

Distribution

Tetracyclin is widely distributed in tissues and fluid fluid, concentration in cerebrospinal fluid is relatively low, but can increase in the case of meningitis, a small amount appears in saliva, tears and lung fluid, tetracyclin also appears in breast milk with a concentration of 60% or 60% or more than the concentration of drugs in the mother's blood.

Tetracyclin through the placenta and appears in the fetal circulation with a concentration of 25 - 75% compared to the concentration of drugs in the mother's blood. The drug is attached to the bone during the new bone formation, the calcification process and affects the process of forming bones and teeth.

Elimination

Tetracyclin in the form of oral doses is discharged through urine in unproperated form. Tetracyclin is also concentrated in the liver, excreted through bile into the intestines and partly reabsorbed back through the liver - intestines.

Before taking Tetracyclin TW3 500mg Treatment of infections, plague (10 blisters x 10 tablets)

How to use

Take 1 hour before eating or after 2 hours.

Dosage

Adults: 1 tablet/time, every 6 hours.

Children over 8 years old: drink 25 - 50 mg/kg body weight/day, divide 2-4 times.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? With minor adverse reactions, usually just stop the drug. In case of severe sensitivity or allergic reactions, supportive treatment should be carried out (keeping epinephrin, oxygen breathing, antihistamine, corticosteroids ...).

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Tetracyclin 500 mg TW3, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: Nausea, vomiting, diarrhea.

Metabolism: Babies are underdeveloped and discolored when using tetracyclin for pregnant women and children under 8 years old. other reactions: Increased development of antibiotic bacteria and the risk of developing antibiotic -resistant intestinal bacteria.

Uncommon, 1/1000

Digestive: ulcers and esophagus narrowing.

skin: skin allergic reaction, urticaria, edema, increase in sunlight.

Instructions on how to handle ADR

Stop using tetracyclin. With minor adverse reactions, usually just stop the drug. In case of severe sensitivity or allergic reactions, supportive treatment should be conducted (keeping Epinephrin, oxygen breathing, antihistamine, corticoid ...).

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Tetracyclin 500 mg contraindicated in the following cases:

Sensitive people with any tetracyclin.

Pregnant and lactating women, children under 8 years old.

Be cautious when using

tetracyclin can cause excessive growth of non -sensitive microorganisms, including mushrooms. If the infection occurs, it is necessary to stop the drug and replace it with another appropriate regimen.

When long -term treatment, periodic tests are required to evaluate liver, kidney and hemorrhage.

Some cases of tetracyclin use a sensitive reaction to light manifested by sunburn when exposed to sunlight. Patients who use tetracyclin if exposed to direct sunlight or ultraviolet rays should be warned about this risk and need to stop the drug as soon as there are the first symptoms of the erythema.

The ability to drive and operate machinery

does not affect.

Pregnancy

Do not use Tetracycline antibiotics for pregnant women. The use of tetracyclin in and near pregnancy will cause harmful consequences for teeth and bone, toxic to the liver of pregnant women, causing birth defects.

breastfeeding period

tetracyclin distributed in breast milk. Although tetracyclin can create calcium in breast milk, unapproached complexes, it is not recommended to use tetracyclin during breastfeeding due to permanent teeth coloring, reducing enamel production, inhibiting bone growth, light sensitive reactions and candidiasis in the mouth and young vagina.

Drug interaction

tetracyclin and penicillin: Tetracyclin reduces penicillin activity in the treatment of meningitis caused by pneumococcal and may also be pink.

tetracyclin and anti -acid drugs: plasma tetracyclin concentrations lead to antibiotic treatment activity significantly or completely lost if used with aluminum, bismut, calcium or magnesi -containing drugs.

Tetracycline and diuretics: There are recommendations not to coordinate tetracyclin with diuretics because this interaction leads to hyperur with hyperur.

Tetracyclin and iron -containing preparations: combination of tetracyclin with iron salts significantly reduces the absorption of both drugs in the intestine, leading to a decrease in serum levels, treatment effect reduction or loss. If it is required to use both of these drugs, the time to drink them must be apart as long as possible to avoid mixing these two drugs in the intestine.

Tetracyclin and milk and dairy products: absorbing tetracyclin significantly (up to 70 - 80%) if used in the same milk and dairy products, leading to reduction or loss of treatment ability.

Storage

In a cool, dry place, the temperature does not exceed 30 degrees Celsius, avoiding light.

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