The domenic oral phlegm is 10mg/10ml to treat vomiting, nausea (20 tubes x 10ml)

Dosage form Drink
Specifications Box of 4 blisters x 5 tubes
Ingredient Domperidon

Ingredient

Thành phần cho 10ml

Composition information	Content
Domperidon	10mg

Uses

Indications

domenic domenic indications in the following cases:

Treatment of vomiting and nausea. Because the drug has almost no effect on the dopamine receptors in the brain, the domeridon has no effect on mental and nervousness.

Domperidon stimulates the peristalsis of the gastrointestinal tract, increases the tasting muscle tone and increases the amplitude of the pyloric sphincter after meals, but does not affect the excretion of the stomach. The drug is used to treat nausea and acute vomiting, both nausea and vomiting due to the use of levodopa or bromocriptin in Parkinson's disease.

pharmacokinetic

absorption

domperidon is absorbed in the digestive tract but has low oral bioavailability (in hungry people only about 14%) due to the initial metabolism of the drug through the liver and metabolism in the intestine. The biological use of the drug after oral oral increases significantly if taking the drug 90 minutes after eating, but the time to reach the peak concentration in plasma is slowed down.

Distribution

Biology of the drug after oral oral increases in proportion to the dose of 10 to 60mg, 92 to 93% of the drug attached to plasma proteins.

Metabolism

Metabolic drugs are very fast and much thanks to hydroxylation and reducing oxidation N-alkyl.

Elimination

Half lifetime eliminates in healthy people about 7.5 hours and lasts for kidney failure. There is no phenomenon of drugs accumulated in the body due to renal failure, as the renal clearance is much lower than the total clearance of plasma. Domperidon excreted in feces and urine, mainly in the form of metabolites, 30% of oral doses excreted in urine for 24 hours (0.4% are intact), 66% excreted in feces within 4 days (10% is intact). Domperidon almost does not pass the blood - brain barrier.

Before taking The domenic oral phlegm is 10mg/10ml to treat vomiting, nausea (20 tubes x 10ml)

How to use

domenic doses should only use the lowest doses effectively in the shortest time to control vomiting and nausea.

Should drink domenic before meals. If taken after meals, the drug may be slowly absorbed.

Patients should take medicine at fixed time.

If you forget 1 dose, you can skip the dose and continue taking the drug as scheduled as before. Do not double the dose to compensate for the forgotten dose.

Maximum treatment time should not exceed a week.

Dosage

Adults and adolescents (aged 12 years and older and weighing 35kg or more)

Use 10ml (or 1mg/ml of oral fluid) up to 3 times a day with a maximum dose of 30ml/day.

Patients with liver failure

domenic domenic against patients with medium and severe liver failure. No need to adjust the dose for patients with mild liver failure.

Patients with renal failure

Due to the prolonged semi -discharged time of the domeridon in patients with severe renal impairment, it is used to repeat, the number of domenic drugs should be reduced to 1 to 2 times/day and adjust the dose depending on the degree of renal failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

Symptoms and overdose signs have been reported mainly in infants and children. Symptoms of overdose may include agitation, a sense of changes, seizures, disorientation, drowsiness and foreign reactions.

Handling

There is no specific antidote. In case of large overdose, stomach lasers need to use activated carbon for 1 hour when taking the drug. Anti -anti -cholinergic drugs, Parkinson's anti -Parkinson drugs can be effective in controlling foreign reactions. In the case of an overdose, it is necessary to take symptomatic treatment immediately. Should monitor the electrocardiogram because it is likely to extend QT.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using an unwanted domenic domenic (ADR).

Common, ADR> 1/100

Digestive: dry mouth.

Uncommon, 1/1000

Mental: loss of sexual desire, anxiety.

nerve: Sleep, headache. digestive: diarrhea. skin and subcutaneous tissues: rash, itching.

Reproduction and breast: Increased milk secretion, breast pain.

Other: Myasthenia.

Not determined frequency

Anaphylactic reaction: Including anaphylaxis.

Mental: Anxiety, stress. nerve: epilepsy, extracurricular syndrome.

Eye: eye seizures.

Cardiovascular: ventricular arrhythmia, prolonged QT interval, torsion, sudden death. skin: urticaria, angioedema. kidney: urinary retention.

Reproduction and breast: female mammary glands, amenorrhea.

Other: Examining abnormal liver function, increasing blood prolactin.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Contraindicated

Dopmenic drugs contraindicated in the following cases:

Hypersensitivity to domperidon or any ingredient of the drug.

vomiting after surgery.

Gastrointestinal bleeding.

Mechanical intestine.

Children under 1 year of age.

Use domperidon regularly or long -term.

Pituitary gland increases prolactin secretion, perforation.

Patients with average and severe liver failure.

Patients with prolonged heart impulse transmission time, especially QT interval, patients with clear electrolytes or patients with cardiovascular disease such as congestive heart failure.

Simultaneously used with drugs that extend QT.

Simultaneously used with CYP3A4 inhibitors (no side effects that extend QT).

Children weighing under 20kg.

Caution when using

due to sorbitol ingredients, should not be used for patients with rare genetic disorders in tolerance.

Renal failure: Domperidon's waste time is prolonged in patients with severe renal impairment. In case of repeat use, the frequency of giving domperidon should be reduced to 1 to 2 times/day depending on the level of renal failure. Can adjust the dose if needed.

Cardiovascular effects: Domperidon extends the QT interval on electrocardiograms.

Epidemic studies show that domeridon may increase the risk of serious ventricular arrhythmia or sudden cardiovascular disease. This risk is higher for patients over 60 years old, patients taking daily doses greater than 30mg and patients with simultaneous use of the drug extending the QT or CYP3A4 inhibitors.

Use domperidon with the lowest doses effectively in adults and children.

Contraindicated domperidon for patients with prolonged heart impulse conduction time, especially QT interval, patients with obvious electrolytes (hypokalemia, hyperkalemia, hypoglycemia), slow heartbeat or patients wearing cardiovascular disease such as congestive heart failure due to risk of ventricular arrhythmia, electrolytic disorders (hypotension, hyperkalemia, blood mageci) Increases the risk of arrhythmia.

Need to stop treating with domperidon and exchange with health workers if there are any symptoms or signs related to arrhythmia. Advise patients to quickly report symptoms on the heart.

The ability to drive and operate machinery

Use for drivers and operate machinery.

Pregnancy

There is little data on the use of domperidon in pregnant women. A mouse study showed that toxicity on the reproductive system at high doses. The potential risk in people is not known. Therefore, the drug should only be used during pregnancy when evaluating and prognosing the benefits of treatment.

Breastfeeding period

domperidon excreted through breast milk and breastfed babies receive less than 0.1% dose according to the mother's weight. The adverse effects, especially the effect on the heart, can still occur after a baby breastfed. The benefits of breastfeeding and the benefits of mothers treat to decide to stop breastfeeding or stop/avoid domeridon treatment. Caution should be careful in cases where there is risk factors that extend the QT interval in breastfeeding.

Medicine interaction

can use domperidon along with anxious antidote.

Cholinergic anti -antacids can inhibit the effects of domperidon. If forced to combine with these drugs, atropine can be used after giving domperidon.

If using domperidon along with antacids or acid -secreting drugs, taking domperidon before meals and having to take antacids or acid inhibitors after meals.

Contraindicated with the following drugs:

Medications that extend the QT range:

IA's anti -arrhyths (for example: disopyramid, hydroquinidin, quinidine).

Anti -arrhythmia group III (for example: Amiodaron, dofetilid, droneedaron, ibutilid, sotalol).

Some anti -psychotic drugs (for example: Haloperidon, Pimozid, Servinol).

Some antidepressants (e.g. citalopram, Escitalopram).

Some antibiotics (for example: erythromycin, levofloxacin, moxifloxacin, spiramycin).

Some antifungal drugs (for example, pentamidin).

Some medications for malaria treatment (especially halofantrin, lumefantrin).

Some gastric - intestinal drugs (for example: Cisaprid, Dolasetron, Prucaloprid).

Some antihistamine drugs (for example: Mequitazin, Mizolastin).

Some cancer treatments (for example: Toremifen, Vandetanib, Vincamin).

Some other drugs (for example: Bepridil, Diphemanil, Methadon).

Strong CYP3A4 inhibitors (regardless of the effect of extending QT), for example:

Protease inhibitors.

Azol -body antifungal drugs.

Some macrolid drugs (erythromycin, clarithromycin and telithromycin).

It is not recommended to simultaneously use the following drugs: Average CYP3A4 inhibitors, for example: Diltiazem, Verapamil and some macrolid drug groups.

Use cautiously when used simultaneously with the following medications: Slow heart rate, medications that reduce blood potassium and some following macrols contribute to the QT interval: azithromycin and Roxithromycin (contraindicated clarithromycin due to being strong CYP3A4 inhibitors).

The list of substances above is representative and incomplete drugs.

Storage

Temperature does not exceed 30 ° C.

Other drugs

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