The Novomix 30 Flexpen Novo Nordisk injection pen treats diabetes (5 trees x 3ml)

Dosage form Box of 5 trees x 3ml
Specifications Dissolved insulin aspart, insulin aspart crystallized with protamine

Ingredient

Thành phần cho 3ml

Composition information	Content
Insulin aspart dissolved	30%
Insulin Aspart crystallizes with protamine	70%

Uses

indicated

Novomix 30 Flexpen injection pen is indicated for treating patients diabetes need to be treated with insulin.

Pharmacokic

The effect of reducing the blood sugar of insulin aspart is due to increasing glucose absorption by attaching insulin into receptors on muscle and fat cells, and at the same time inhibits the production of glucose production from the liver.

When injecting Novomix 30 under the skin, the drug will initiate effect within 10 to 20 minutes after the injection. The peak is about 1 to 4 hours after the injection. The effect time lasts up to 24 hours.

In a 3 -month clinical study, the comparison between Novomix 30 and insulin 30 2 -phase effect used before breakfast and dinner in patients with type 1 diabetes and type 2 diabetes, resulting in Novomix 30 significantly reduced blood sugar after eating both meals (breakfast and dinner).

A gross analysis consists of 9 clinical studies in patients with type 1 diabetes and type 2 diabetes shows that compared to the 30 -phase -acting insulin, Novomix 30 treatment before breakfast and dinner for better results in blood sugar control after eating (average increased blood sugar during breakfast, lunch and dinner). While the glycemia is higher than the patients treated with Novomix 30, the overall blood sugar control effect by measuring the haemoglobin glycosylate (HBA1C) is similar.

In a study, 341 patients with type 2 diabetes were chosen to random treatment with the only Novomix 30 injection pen or in combination with metformin , or in combination with Metformin and Sulfonylurea. After 16 weeks of HBA1C treatment, there is no difference between patients using Novomix 30 in combination with Metformin and patients using Metformin and Sulfonylurea. In this study, 57% of patients had HBA1C initially> 9%; In patients treated with Novomix 30 in combination with Metformin, HBA1C has decreased significantly compared to Metformin in combination with sulfonylurea.

In a study of type 2 diabetes patients, the effect of controlling blood sugar is not enough when taking medication to treat single -drink diabetes, randomly selected for treatment with Novomix 30 2 times/day (117 patients) or Insulin Glargine once a day (116 patients). After 28 weeks of treatment with Novomix 30 in the recommended dose, the average reduction of HBA1C was 2.8% (the initial average = 9.7%). With Novomix 30, 66% and 42% of patients reach HBalc

In patients with type 2 diabetes, gross analysis shows the risk of night hypoglycemia and severe hypoglycemia when used with Novomix 30 compared to 2 -phase human insulin (mixed/mixed mix). The risk of daytime hypoglycemia in patients treated with Novomix 30.

In the Children's Humanity: A 16 -week clinical study compares blood sugar control after eating (blood sugar related to meals) of Novomix 30 with human insulin/insulin 30 2 phase (mixed/mixed) and insulin NPH when going to bed have been done in 167 patients aged 10 to 18 years old. The average HBA1C is still similar to the beginning during the study in both the above treatment groups, and there is no difference in the hypoglycemia ratio of Novomix 30 or 2 -phase human insulin (mixed/pre -mixed) 30.

In a smaller group (54 patients) and younger groups (aged 6 to 12 years old), treatment in double, cross -study study (12 weeks for each study) The ratio of hypoglycemia and the post -eating hyperglycemia of Novomix 30 significantly lower than 2 -phase human insulin (mixed/pre -mixed). HBA1C ends research in the treatment group with 2 -phase human insulin (mixed/mixed) 30 significantly lower than the treatment team with Novomix 30.

Elderly patients: The pharmacological properties of Novomix 30 are not studied in elderly patients. However, comparative research on PK/PD randomly, diagonal of insulin aspart with insulin insulin (Human -acting insulin) is performed in elderly patients with type 2 diabetes (19 patients aged 65 to 83, average age 70 years old). The relatively difference in pharmacological properties (GIRMAX, AUCGIR 0-120 min) of insulin aspart and insulin insulin (human insulin quickly acted) in elderly patients is similar to healthy people and younger patients with diabetes.

Dynamic pharmacokinetics

In insulin aspart , the replacement of amino acid proline with aspartic acid at the B28 position reduces the tendency to create 6 molecules (Hexamer) in the solubility of human insulin. Insulin aspart in the dissolved (fast phase) phase of Novomix 30 consists of 30% of total insulin; This part is absorbed from subcutaneous tissue faster than the soluble insulin ingredient of 2 -phase human insulin (mixed/mixed) 30. 70% remaining in the form of crystals is insulin aspart protamine, this form has a long absorption chart similar to the NPH human insulin.

Average, maximum serum insulin concentration of Novomix 30 is 50% higher than 2 -phase insulin. On average, the maximum time of concentration is 1/2 compared to the 30 -phase effect.

In healthy volunteers, the maximum maximum serum concentration is 140 ± 32 PMOL/l reaching about 60 minutes after 1 -dose of 0.20 U/kg body weight. The average half -life (T1/2) of Novomix 30 reflects the absorption rate of the protamine mounting part of about 8 - 9 hours. Serum insulin concentration returns to normal levels of 15 - 18 hours after subcutaneous injection. In patients with type 2 diabetes, the maximum concentration reaches about 95 minutes after the injection and the measurement concentration is still greater than 0 with no less than 14 hours of injection.

A group of elderly patients

The pharmacokinetic properties of Insulin Novomix 30 injection pen are not studied in elderly patients. However, the relative difference in the pharmacokinetic properties of insulin aspart and insulin people dissolve in elderly patients (ages 65 to 83, on average 70 years old) with type 2 diabetes are similar in health and younger patients with diabetes. Reducing the absorption ability to be observed in the elderly, resulting in 82 -minute TMAX time (ranging in about 60 to 120 minutes) while CMAX is similar in younger patients with diabetes in type 2 and slightly lower than patients with type 1 diabetes.

Patients with liver and kidney failure

The pharmacokinetics of Novomix injections are not studied in patients with liver and kidney failure.

Pediatric patients

The pharmacokinetics of Novomix 30 are not studied in children or adolescents. However, the pharmacokinetic and pharmacokinetic characteristics of the soluble insulin aspart have been studied in children (6 to 12 years old) and adolescents (13 to 17 years old) with type 1 diabetes. Insulin Aspart is quickly absorbed in both patients, and TMAX time is similar to adults. However, CMAX has a difference between age groups, which emphasizes the importance importance of insulin according to each individual.

Before taking The Novomix 30 Flexpen Novo Nordisk injection pen treats diabetes (5 trees x 3ml)

How to use

Novomix 30 diabetes pen is only injected under the skin.

Novomix 30 is not intravenous because it can cause excessive hypoglycemia. Injecting should be avoided. Novomix 30 is not used in insulin transmission pumps.

Novomix 30 injection pen is used under the thigh or abdominal wall. If convenient, the buttock muscles or Delta muscles can also be injected. Should change the injection site in the same injection area to reduce the risk of fat disorders. Like all insulin preparations, the injection time depends on the dosage, injection site, blood flow, temperature and physical activity level.

Novomix 30 has a faster onset of 2 -phase insulin (mixed/mixed) and is often used right before meals. When necessary, Novomix 30 can be used immediately after meals.

Instructions for patients.

Do not use Novomix 30 if

If you are allergic (too sensitive) with insulin aspart or with any component of Novomix 30.

If you start suspecting hypoglycemia (low blood sugar).

In insulin transmission pumps.

If Insulin injection pen Novomix Flexpen falls, damaged or broken.

If the pen is not preserved or frozen.

If the drug is not uniformly opaque white when shaking.

If after mixing, there is a hard white sub -stool attaches to the wall or bottom of the tube.

Before using Novomix 30 diabetes, Novomix 30

Check the label to ensure the right type of insulin to use.

Always use new needles for each injection to prevent infection.

Do not use the same needle and Novomix 30 Flexpen.

Novomix 30 is used for subcutaneous injection (subcutaneous injection). It is never injected directly into the vein (intravenous) or intramuscular (injected in muscle).

For each injection, change the injection site in the same skin area. This helps reduce the risk of skin tumors and pitting. The best injection site is: the front of the belt (abdomen); butt; The front of the thigh or above the arm. This insulin will impact faster if it is injected around the abdomen. You should measure your blood sugar regularly.

How to handle Novomix 30 Flexpen?

Read the instructions for using the Novomix 30 Flexpen instructions carefully before use. If you do not follow the instructions carefully, you can get too little or too much insulin, which can lead to too high or too low blood sugar level.

Novomix 30 Flexpen is a pre -pumped insulin injection pen.

You can rotate to determine the dose from 1 to 60 units by increasing 1 unit.

Novomix Flexpen injection pen is designed for use with a 8 mm long Novotwist.

always carry an insulin flexpen in case of loss or damage.

Novomix 100iuml

Novomi 100iumL 1

1. Homogeneous insulin

a. Check the name and label color of the pen to ensure the correct type of insulin. This is especially important if you use more than one type of insulin. If you use the wrong insulin, the blood sugar level may be too high or too low.

Each time you use a new pen.

Bring insulin to room temperature before use. This makes it easier to mix.

Open the pen cap.

b. Before the first injection with Flexpen pen, you have to identify insulin:

Rolling the pen between the palms 10 times - It is important to hold the pen in the horizontal (horizontal with the ground).

c. After that, move the pen to get up and down between the two positions as shown (Figure C) 10 times for the small ball to move from one end to the other end of the pen of the pen.

Repeat the rolling process and move until the solution in the pen becomes uniform white.

For each injection.

Move the pen in and down between the two positions at least 10 times until the solution of the pen in the pen becomes uniform white.

Always make sure you have homologous insulin before each injection. This reduces the risk of blood sugar too high or too little insulin, taking the steps immediately.

2. Attach Kim

d. Take a new needle and tear the paper. Turn and tighten the needle into Flexpen.

e. Remove the large outer lid and hold it later.

f. Remove the small inside and throw it away. Never try to cover the needle back to the tip of the needle. You can be stabbed into your hand.

3. Insulin flow test

Before each injection may have a small amount of air at the tip of the needle and the pipe during normal use. To avoid air injection and ensure accurate dose.

g. Rotate the dose button to select 2 units.

h. Put the Novomix pen with a needle on top and use a finger to tap it a few times to make the air bubbles move to the top of the medicine tube.

i. Hold the needle upwards, press the button to get the drug in the fullest. Select the injection dose button back 0.

A drop of insulin appears at the tip of the needle. If not, replace the needle and repeat this process not more than 6 times.

If a drop of insulin does not appear, the pen is damaged, you must use a new pen.

4. Injecting dose

Check the injection dose button in position 0.

j. Rotate the risk button to the number of units to be injected.

Injectable dose can be adjusted to increase or decrease by rotating the up and down dose button until the point is indicated with the cursor. When adjusting the dose, be careful not to press the injection button, causing insulin to escape.

You cannot do the larger dose than the remaining drugs in the pen.

5. Injection

Stabbing the needle through the skin. Injecting techniques are performed by a doctor or nurse.

k. Inject the drug by pressing the button to inject the drug to the fullest until the point is only 0 straight with the cursor. Be careful only to press the pump button when injecting.

l. Rotate the dose button if not injected insulin.

Hold the drug button in the down position and leave the needle under the skin for at least 6 seconds to make sure all the drugs are injected.

Remove the needle from the skin, then drop the injection button.

Always make sure the button options to return to point 0 after injection. If the stop button stops before returning to the point 0, the dose will not be fully received, this leads to too high level of blood sugar.

m. Lead the needle into the large needle lid outside without touching it. When the needle is completely tightly closed, carefully pushing the large needle lid completely and turning the needle back.

Discard the needle carefully and cover the lid of the pen.

Note when using

Always check at least 12 remaining insulin units in the pipe to be able to shake the drug. If there are less than 12 units, use a new flexpen pen. 12 units are marked on the medication quantity ladder. See a large picture at the beginning of this tutorial.

Do not use pen if insulin after mixing mixed without heterogeneity and opaque head of this tutorial.

Always use a new needle for each injection. This reduces the risk of infections, bacterial infections, insulin leaks, metal obstruction and incorrect dose.

Be careful not to bend or damage the needle before use.

Always make sure a drop of insulin appears at the tip of the needle before the injection. This is definitely not clogged insulin injection pen. If the insulin drop does not appear, you should not inject insulin even though the dose button is still moving. This leads to too high levels of blood sugar.

Always use the dose and needle button to find out how many units you choose before injecting insulin.

Do not count the pen of pen. If you choose and inject the wrong dose, your blood sugar level may be too high or too low. Do not use the medication ladder, it only indicates how much insulin is in the pen approximately.

Always cancel the needle after each injection and preserve the insulin Novomix flexpen injection pen without needles. This reduces the risk of infections, bacterial infections, insulin leaks, metal blockages and incorrect doses.

More important information

The caregivers must be very careful when treating needles when used to avoid needle and cross -bacterial infections.

Cancel cancellation has been used carefully, not attached to needles.

Never use the same pen or needle with others. Can lead to cross -bacterial infections.

Never use the same pen with others, your medicine is harmful to their health.

Always keep the pen and needles in the vision and reach of others, especially children.

Your pen care

Novomix Flexpen diabetes pen must be used cautiously. If falling, damaged or broken, there is a risk of insulin leakage. This can cause incorrect doses, which can lead to too high or too low blood sugar levels.

You can clean the outside of Flexpen by wiping it off with medical gauze. Do not soak, wash or lubricate because it can damage the pen.

Do not pump insulin into flexpen injection pen.

Dosage

Novomix 30 dose depending on the patient and are determined to do the dosage according to the needs of the patient. Monitoring blood sugar and adjusting insulin dose is recommended for optimal effect in blood sugar control.

In patients with type 2 diabetes, Novomix 30 injection pen can be used single. Novomix 30 can also be combined with oral diabetes pills when unable to control blood sugar with pills to treat pure oral diabetes.

Howlin arises?

Patients who have not used insulin:

For patients with type 2 diabetes, the recommended starting dose of Novomix 30 is 6 units at breakfast and 6 units at dinner (dinner). However, it can also be used 1 time/day at a dose of 12 units at dinner (dinner).

How to convert?

When transferring patients from 2 -phase human insulin (mixed/mixed) to Novomix 30, starting with the same dose and mode. Then adjust the dose according to the needs of each patient. Like all insulin preparations, closely monitor blood sugar during conversion and the first weeks.

How to treat it?

Novomix 30 can be used for enhanced treatment 1 time/day to 2 times/day. When using the Novomix 30 -day injection pen, the dose has been up to 30 u, it is often recommended to switch to treatment divided into 2 times/day by dividing the same dose at breakfast and dinner (50/50).

From Novomix 30 days 2 times to 3 times: Morning dose can be divided into morning and lunch time (use 3 times/day).

How to adjust the dose?

Adjust the dose of Novomix 30 is based on blood sugar levels before the lowest meal of the previous 3 days.

Always adjust the dose earlier with blood sugar levels before meals.

Adjust the dose can be done once a week until HBA1C goals.

Do not increase the dose if hypoglycemia occurs in these days.

The dose adjustment may also be necessary if the patient enhances physical activity or changes the daily diet or has an accompanying disease.

Dosage adjustment guidelines are recommended for the dose adjustment:

Sugar level before meals adjust the dose of Novomix 30 Flexpen

mmol/l

80-110 mg/dl 0 4U 10 mmol/l

Like all insulin preparations, in special patients, blood sugar monitoring should be enhanced and the dose of insulin aspart is adjusted based on patient needs.

Elderly

Novomix 30 can be used in elderly patients; However, there is little experience using a combination of Novomix 30 with oral diabetes pills in humans over 75 years old.

Patients with liver and kidney failure

Can reduce insulin needs of patients with liver and kidney failure.

Children

Novomix 30 injection pen can be used for children and teenagers to 10 years old and bigger if suitable for 2 -phase insulin (mixed/mixed). Few clinical data for children from 6 to 9 years old (see section of pharmacological properties).

There is no data on Novomix 30 in children under 6 years old.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? However, hypoglycemia can occur through the following stages if the dose is too high compared to the patient needs:

Mild hypoglycemia, can be treated using oral glucose or sugar products. Therefore, patients with diabetes are always carrying people with sugar products.

Severe hypoglycemia, when the patient is unconscious, can be treated with intramuscular injection or subcutaneous injection of Glucagon (0.5 to 1 mg) due to a person who has been trained, or glucose transmission by intravenous lines by medical staff. Intravenous glucose must be transmitted if the patient does not respond to glucagon within 10-15 minutes. When the patient wakes up, the patient eats foods containing carbohydrates to avoid coma again.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Novomix 30 drugs , you may experience unwanted effects (ADR).

Summary of safety

Unwanted effects are observed in patients using Novomix mainly due to the pharmacological effects of insulin.

The most common adverse reaction during the treatment process is reported as hypoglycemia. The frequency of hypoglycemia is different for patients, the dose regime and the level of blood sugar control (see section C below).

When starting with insulin treatment, refractive, edema and reaction at the injection site (including pain, redness, urticaria, inflammation, bruising, swelling and itching). These reactions are often transient. The rapid improvement in blood sugar control may be related to acute neurological pain, which can be recovered. The active insulin treatment with sudden improvement in blood sugar can be associated with retinopathy due to diabetes deteriorating temporarily, while blood sugar control has been improved for a long time, reducing the risk of diabetic retinopathy progression.

Understanding reactions

Very common, ADR> 1/10

Metabolic and nutrient disorders: Hypoglycemia.

Uncommon, 1/1000

immune system disorders: rash urticaria , ban, rash.

Eye disorders: refractive disorders, diabetes retinopathy.

Skin and subcutaneous tissue disorders: Lipid disorders (lipids), reaction at the injection site, edema.

Rare, 1/10000 ≤ ADR

Nervous system disorders: peripheral neuropathy (neuropathy).

Very rare, ADR

immune system disorders: Anaphylaxis.

Describe the selective adverse adverse reactions

Anaphylactic reaction

Symptoms of hypersensitivity (including body rash, itching, sweating, stomach discomfort, nervous-mental edema, shortness of breath, chest drum and lower blood pressure ) are very rare but can be life-threatening.

Hypoglycemia

The most common adverse reaction is reported to hypoglycemia. It may occur when insulin dose is too high compared to the need to use insulin. Hypoglycemia can lead to unconsciousness and/or convulsions and can lead to temporary or permanent brain failure or even death. Symptoms of hypoglycemia usually occur suddenly. They include cold sweat, pale skin, fatigue, restlessness, tremor, anxiety, fatigue or abnormal weakness, confusion, difficulty in concentration, drowsiness, excessive hunger changing vision, headache , nausea and chest drum.

In clinical studies, the frequency of hypoglycemia is different in each patient object, the dose regime and the level of blood sugar control. In clinical studies, the ratio of hypoglycemia in general has no difference between patients treated with insulin aspart and human insulin.

Fatty disorder

Fatty disorders (including over -fat tissue hypertrophy or fat atrophy) may occur in the injection site. Continuous changes in the injection site in the same injection area reduces the risk of developing these reactions.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Novomix 30 contraindications in cases of hypersensitivity to insulin aspart or any excipient of the drug.

Be cautious when using

read the user manual carefully before use. If you need more information, please consult your doctor.

This drug is only used as prescribed by the doctor.

Before moving to different geographical areas, patients should consult a doctor's advice because this means that patients use insulin at meals at different times.

Hyperglycemia (high blood sugar)

Inadequate or non -continuous treatment, especially in patients with type 1 diabetes, can lead to hyperglycemia and diabetes metonic acidosis. Usually the first symptoms of hyperglycemia appear gradually over a period of several hours or days. Symptoms include thirst, increased frequency of urination, nausea, vomiting, drowsiness, dry skin, dry mouth, anorexia and ceton smell. In patients with type 1 diabetes, untreated hyperglycemia can lead to metonic acidosis caused by diabetes.

Hypoglycemia (low blood sugar)

Forget a stressful meal or exercise, there is no plan that can lead to hypoglycemia. Hypoglycemia may occur if the insulin dose is too high compared to insulin needs (see unwanted and overdose effect).

Compared to 2 -phase human insulin (mixed/mixed), Novomix 30 can have a stronger hypoglycemic effect of up to 6 hours after injection. This may have to be adjusted for each patient's individual by adjusting the insulin dose and/ or the amount of food.

Patients with blood sugar control have been greatly improved, for example, due to positive insulin therapy, may occur changes in previous symptoms that are usually hypoglycemia and should be consulted by a doctor. Warning symptoms can often be lost in patients with long -term diabetes.

Strictly controlling blood sugar levels can increase hypoglycemia and thus requires special attention during the dose increasing process as stated in the dose section.

Novomix 30 diabetes pen should be used immediately related to meals. Therefore, the onset of effects must be considered in patients with pathology that comes with or taking the medicine with drugs that slow down the absorption of food.

The accompanying pathologies, especially infections, fever, often increases the patient's insulin demand. In case of kidney, liver or adrenal, pituitary, and thyroid diseases may require changes in insulin dose.

When the patient is converted between different types of insulin, the early signal symptoms of hypoglycemia may change or less than the previously used insulin.

Conversion from other insulin preparations

Patients switch to using insulin or new insulin brands should be performed under the close monitoring of health workers. Changes in content, brand (manufacturer), type, type (human insulin, Insulin analogue and/or production process can lead to the need for dose changes.

Patients switching to using Novomix 30 from other insulin may require an increase in the number of injections/day or change the dose compared to the previously used insulin. If the adjustment is necessary, it can be done at the first dose or in the first few weeks or the first few months.

Reaction at the injection site

Like any insulin therapy, the response at the injection site may occur including pain, redness, urticaria, inflammation, bruising, swelling and itching. Continuing to change the injection site in a certain area will help reduce the risk of these reactions. These reactions disappear for a few days to a few weeks. In case of donation, reaction at the injection site may need to stop using Novomix 30.

Combining thiazolidinediones with insulin products

Cases of congestive heart failure have been reported when used in combination with thiazolidinedion with insulin, especially in patients with risk factors for congestive heart failure. This should be noted when used combined with thiazolidinediones with insulin drugs. If used in combination, patients should be observed the signs and symptoms of congestive heart failure, edema and weight gain. Thiazolidinediones should be stopped when there are any symptoms of heart failure.

Insulin antibodies

Insulin treatment may appear antibodies of insulin.

In a rare case, the presence of insulin antibodies may need to adjust the correct insulin dose to avoid increasing or hypoglycemia.

The ability to drive and operate machinery

The patient's concentration and reaction ability may be impaired as a result of hypoglycemia. This can be dangerous in situations where these possibilities are of special importance (such as driving or operating machinery).

Patients are advised to be cautious to avoid hypoglycemia while driving or operating machinery. This is very important in patients who are difficult to identify whether or not to recognize the warning signs of hypoglycemia or in patients who often have hypoglycemia. It is necessary to consider driving or operating machinery in these cases.

Pregnancy

few clinical studies on the use of insulin Novomix 30 injection pen during pregnancy. Novomix 30 has not been studied in pregnant women.

However, data from two verified random clinical studies (157 and 14 pregnant women, respectively, treated with insulin aspart in the background - fast) does not indicate any unwanted effects of insulin aspart in pregnant women or fetal health/babies when compared to human insulin.

In general, positive control of blood sugar and monitoring pregnant women with diabetes is recommended during pregnancy and when intending to get pregnant. The demand for insulin usually decreases in the first 3 months of pregnancy and gradually increases in the middle 3 months and the last 3 months of pregnancy. After birth, insulin demand quickly returns to the level of pregnancy.

breastfeeding period

There is no restriction on the treatment with Novomix 30 during breastfeeding. The treatment of insulin for mothers during breastfeeding does not risk children. However, maybe the dose of Novomix 30.

Drug interaction

Some drugs are known to interact with glucose metabolism. The following drugs may reduce the patient's insulin demand: oral diabetes treatment, inhibit monoamine oxidase (Maois), beta blockers, inhibit enzymes (ACE), Salicylates, Steroid assimilation and sulfonamides.

The following drugs may increase the patient's insulin demand: oral contraceptives, thiazides, glucocorticoids, thyroid hormones, sympathetic strengths, growth hormones and danazol .

Beta blockers can cover the symptoms of hypoglycemia.

octreotide /Lanreotide may increase or decrease insulin demand.

Alcohol can increase or decrease the hypoglycemic effect of insulin.

Storage

Store in the refrigerator (2 ° C - 8 ° C). Stay away from the cooling unit. Do not freeze.

The expiry date is printed on the packaging.

After bringing the Insulin Novomix 30 Flexpen pen to the refrigerator, it is recommended to bring back room temperature before mixing (homogeneous) insulin for the first use as instructions.

Store when used and backup: Novomix 30 Flexpen is using or carrying preventive preventive in the refrigerator. It can be kept at room temperature (below 30 ° C) for 4 weeks.

Close the flexpen injection pen to avoid light.

Novomix 30 injection pen must be protected from excessive light and heat.

Instructions for use, manipulation and cancellation

needles and Novomix 30 Flexpen are not shared, the pipe is not recharged. Novomix® 30 is not used if the mixture is not uniformly white. The need for homogeneity of the Novomix 30 Flexpen mixture right before the injection must be emphasized to the patient.

Do not use Novomix 30 has been frozen.

Patients need to be still still canceling needles after each injection.

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