The oral phosphate of profen ibuprofen100mg/10ml CPC1HN analgesic, reducing fever in children (2 blisters x 5 tubes)

ATC code: M01AE01

ibuprofen is an nonsteroidal anti -inflammatory drug, derived from propionic acid. Like other nonsteroidal anti -inflammatory drugs, ibuprofen has the effect of reducing the head, antipyretic and anti -inflammatory.

The mechanism of action of the drug is Prostaglandin inhibitors Synthetase and thus preventing prostaglandin, thromboxan and other products of cyclooxygenase. Ibuprofen also inhibits prostacyclin synthesis and can cause water stasis risk due to reducing blood flow to the kidneys.

It is important to pay attention to this for patients with kidney failure, heart failure, liver failure and disorders with plasma volume disorders.

ibuprofen has a stronger antipyretic effect than aspirin, but inferior to indomethacin. The drug has good anti -inflammatory effects and has good analgesic effect in the treatment of teenagers.

pharmacokinetics

ibuprofen well absorbed in the digestive tract. The maximum concentration of the drug in plasma is achieved after 1 to 2 hours. The drug is highly attached to plasma proteins. Half life of the drug is about 2 hours. Ibuprofen eliminates very quickly through the urine (1% in constant form, 14% in the form of combined).

If the patient looks blurred, reduces vision, or color reception disorders, Ibuprofen must be stopped.

If there is a mild digestive disorder, you should take medicine when eating or drinking with milk.

Be cautious when using

The unwanted effect of the drug can be minimized by the lowest use of the lowest doses in the shortest time to control symptoms.

Patients with rare genetic problems are the ability to intolerine fructose, malventine-galactose absorption or deficiency of sucrase-isomaltase should not use this medication.

As other NSAID drugs, ibuprofen can hide signs of infection.

Avoid combining drugs with other NSAIDs, including selective inhibitors on COX-2 (cyclooxygenase-2) due to increased risk of ulcer or bleeding.

Be careful when using ibuprofen for the elderly due to increasing the adverse reaction frequency of NSAIDs, especially gastrointestinal bleeding, gastric perforation and can be fatal.

Increased risk of kidney failure in children and adolescents.

Gastrointestinal hemorrhage, ulcerative or perforation can be reported to all NSAIDs at any time during the treatment period including having or without symptoms related to the previous digestive system.

The risk of gastrointestinal bleeding, ulcers or perforation increases when increased by NSAIDs, in patients with a history of ulcer, especially patients with hemorrhage disorders and in the elderly. These patients should be treated at the lowest doses and still meet the effectiveness. Combined with stomach protection (such as Misoprostol) or proton pump inhibitors that need to be considered in these patients and also consider low -dose aspirin use simultaneously or other drugs may increase risk to the digestive system.

In patients with a history of gastrointestinal tract, especially the elderly, it is necessary to report the arrest often related to the digestive system (especially gastrointestinal bleeding) especially in the early stages of treatment.

When gastrointestinal bleeding or ulcers occurs due to the use of ibuprofen preparations, it is necessary to stop the drug.

In patients with a history of ulcerative colitis or Crohn's disease, it should be paid special attention when using NSAIDs, because the use of NSAIDs can make the disease worse.

Respiratory disorders:

Caution for patients with a history of bronchial asthma when using NSAIDs can increase the risk of bronchospasm.

heart, kidney, liver:

When using NSAIDs can inhibit the formation of prostaglandin leading to renal failure, especially in patients with impaired renal function, heart failure, liver dysfunction or diuretics, fake people. Kidney function should be closely monitored in these objects.

Edema has been reported in patients with heart failure or high blood pressure.

Cardiovascular and cerebrovascular

It is necessary to have a reasonable supervision and priesthood for patients with a history of hypertension and or patients with mild to medium hemorrhage heart failure due to the ability to retain water or coverage. Clinical research shows that the use of high -dose ibuprofen (2400 mg/day) increases the risk of increasing arterial thrombosis such as myocardial infarction or stroke, but with low doses (≤ 1200 mg/day), there is no report on this disadvantage.

In patients with systemic erythematosus lupus (SLE) and mixed connective tissue disorders may increase the risk of aseptic meningitis.

Dermatology: Some serious skin reactions such as flaking dermatitis, Stevens - Johnson syndrome, symbolic necrosis have been reported when used in combination with NSAIDs, but very rare. Ibuprofen should be discontinued if there are some of the following signs: skin rash, mucosal damage, or any hypersensitive signs.

Hematology: Ibuprofen as well as other NSAIDs can inhibit platelet aggregation and cause prolonged bleeding time in normal people.

ibuprofen reduces fertility in women so it should not be used or stopped using ibuprofen for those who are treating infertility, women who are pregnant.

In the profen formula contains sorbitol, therefore be careful when used for non -tolerated sorbitol objects. With sorbitol dose up to 140 mg/kg/day, there may be a feeling of uncomfortable intestinal and light laxative.

Risk of cardiovascular thrombosis:

Non -steroid anti -inflammatory drugs (NSAIDs), non -aspirin, use systemic sugar, may increase the risk of cardiovascular thrombosis, including myocardial infarction and stroke, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recorded mainly at high doses.

Doctors need to periodically evaluate the appearance of cardiovascular events, even if the patient has no previous cardiovascular symptoms. Patients should be warned of symptoms of serious cardiovascular events and need to visit a doctor as soon as this symptom appears.

To reduce the risk of adverse incidents, the lowest daily daily daily dose is needed in the shortest possible time.

Use drugs for women during pregnancy and lactation

Pregnant women

Anti -inflammatory drugs can inhibit uterine contractions and slow delivery.

Non -steroid anti -inflammatory drugs can also cause severe lung pressure and severe respiratory failure in infants due to early uterus. Anti -inflammatory drugs also CPC1HN
platelet function, increasing the risk of bleeding.

After taking nonsteroidal anti -inflammatory drugs, there is also a risk of less amniotic fluid and anuria in babies. In the last 3 months of pregnancy, it must be very limited to use for any anti -encephalitis.

These drugs also have absolute contraindications in a few days before birth.

breastfeeding women

ibuprofen into breast milk is very small, negligible. Less likely to occur risks for children at normal doses with mothers.

The effect of the drug on the ability to drive and operate machinery

The drug causes some unwanted effects such as headache, dizziness, restlessness. Need to be cautious when using drugs for patients driving or operating machinery.

Interactive drug

Caution should be careful with patients treated with any of the following drugs in the category
the following interactive drug:

Hematoplasty drugs, beta blockers and diuretics: Ibuprofen reduces the effects of these drugs. Diuretics increase the toxicity of ibuprofen.

Antaginalism: Ibuprofen increases the effects of anticoagulants such as warfarin, heparin ...

Cholestyramin: Concomitance use of cholestyramin with ibuprofen can reduce the absorption
of ibuprofen in the digestive tract. However, clinical significance is unknown.

corticosteroid: increases the risk of gastrointestinal bleeding.

Platelets inhibitors, Serotonin recovery inhibitors: increases the risk of bleeding.

cardiatic glycosides (digoxin): increases the risk of severe heart failure, increases the concentration of heart glycosides in plasma.

Lithi: ibuprofen increases the plasma concentration of lithium.

tacrolimus: Increased risk of kidney toxicity when used with NSAIDs.

For other nonsteroidal anti -inflammatory drugs: increased the risk of bleeding and ulcers.

Magnesi Hydroxyd increases the initial absorption of ibuprofen; But if aluminum hydroxyd is also present, there is no effect.

For other nonsteroidal anti -inflammatory drugs: increased the risk of bleeding and ulcers.

methotrexate: Ibuprofen increases the hematology of methotrexate, especially when using methotrexate at a dose of over 15 mg/week.

ciclosporin: increases the risk of kidney toxicity.

Zidovudin: Increases blood toxicity when used with other anti -inflammatory drugs.

Mifepriston: Do not use NSAIDs within 8-12 days after using Mifepriston.

NSAIDs can reduce the effectiveness of Mifepriston.

Antibiotics Quinolon: Animal research data shows the risk of increased convulsions when combining Quinolon antibiotics and NSAIDs.

aminoglycosides: NSAID can reduce the excretion of aminoglycosides.

Herbal extract: Ginkgo Biloba can increase the risk of NSAID bleeding.

CYP2C9 inhibitor: Concentrated use of CYP2C9 inhibitors (such as voriconazol, fluconazol) with ibuprofen increases ibuprofen levels so it is necessary to reduce the dose of ibuprofen with this CYP2C9 inhibitors.