Theratussin 5mg TV.Pharm treat acute alcohol, respiratory allergy (10 blisters x 25 tablets)

Dosage form Box of 10 blisters x 25 tablets
Specifications Alimemazin Tartrat

Ingredient

Composition information	Content
Alimemazin Tartrat	5mg

Uses

indications

Theratussin 5mg is indicated for treatment in the following cases:

Acute alcoholic state (due to alcohol)

Money before surgery

respiratory allergies (rhinitis, sneezing, runny nose) and skin (urticaria, itching)

Vomiting regularly in children

insomnia of children and adults

Alimemazin is a phenothiazine derivative, which has a strong antihistamine and serotonin resistance, the drug also has a sedative, reducing cough, anti -vomiting.

Alimemazin competes with histamines at H1 histamine receptors, thus having H1 antihydration effect. The drug is against the majority of pharmacological effects of histamine, including urticaria and itching. The peripheral cholinergic anti -peripheral effect of the drug is relatively weak, but it has been manifested in some patients who have used alimemazin (Du Du's mouth, blurred vision, urination, constipation).

Alimemazine has a sedative effect due to the inhibition of nistamine n - methyltransferase and due to the blocking of the central hypamine receptors at the same time with the effect on other ones, especially the serotonergic receptor. This effect is also the basis for using alimermazin as a dedicated medicine.

alinemazin has anti -vomiting effects. The mechanisms of this effect are not fully known. The anti -vomiting effect may be due to the effect of the drug directly on the central region of the chemical sensitivity of the spinal cord. It seems that due to squeezing dopaminergic receptors in this region.

pharmacokinetics

Alimemazin quickly absorbed through the gastrointestinal tract. After taking 15-20 minutes, the drug works and lines 6 ~ 8 hours long. Half a life of plasma is 3.5 - 4 hours, linked to plasma proteins is 20 - 30%.

Alimemazin eliminates the kidneys in the form of sulfoxyd fire transfer (70 - 80%, after 48 hours).

Before taking Theratussin 5mg TV.Pharm treat acute alcohol, respiratory allergy (10 blisters x 25 tablets)

How to use

Theratussin tablets for oral film.

Dosage

Dosage Theratussin cure urticaria, itching

Adults: Take 10mg/time, 2-3 times a day, even up to 100mg/1 day in persistent and difficult cases.

Elderly: Do dose reduction, oral 10mg/time, 1-2 times a day.

Children 2 years and older: drink 2.5 - 5mg/time, 3-4 times a day.

Theratussin dose with anti -histamine, anti -cough effects

Adults: Take 5 - 40 mg/day, divide a lot of encroachment

Children 2 years and older: 0.5 - 1 mg/kg body weight/day, divided many times

Theratussin dose to sleep

Adults: Take 5 - 20 mg, oral before going to bed.

Children 2 years and older: Drink. 0.25 - 0.5 mg4kg body weight/day, oral before going to bed.

Dosage to treat acute alcohol (excitement)

Adults: Take 50 - 200 mg/day.

Do not use Theratussin for children under 2 years old.

What to do when overdose?

Symptoms: Overdose of phenothiazine derivatives cause drowsiness or loss of consciousness, lower blood pressure, increase heart rate, transform electrocardiogram, ventricular arrhythmia and heat lower. The suburban reactions can occur.

Management:

If detected early (before 6 hours, after overdose), it is best to wash the stomach. The method of vomiting is almost unused.

can be used for active carbon. There is no specific antidote. Need supportive treatment. All vessel dilatation can lead to a circuit collapse: enhancing the legs of the patient can be effective, in severe cases, increasing the volume of circulatory venous intravenous intravenously is needed to be warmed before use to avoid serious heat lower body.

Muscle gankers such as dopamine can be used in case the cardiovascular collapse is not resolved by the enemy. Often do not use peripheral vasoconstrictions, avoid adrenalin.

ventricular or erratic tachycardia responds when the body temperature returns to normal and circulating disorders or the fire is adjusted. If continuing or life -threatening, anti -Loan pills can be used.

Avoid using lignoCaine or anti -arrhythmic drugs for a long -lasting effect. When inhibited from the central nervous system, respiratory support is needed. Heavy contraction control reactions often respond to processes (5 - 10 mg) or orphenadrin (20 - 40 each) intramuscularly or intravenously. Convulsions need to be treated with intravenous diazepam intravenously.

Malignant syndrome caused by sedatives should be treated with cooling for patients and can use sodium dantrolen.

What to do when forgetting the dose?

If you forget a dose, use it as soon as possible. However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

The frequency of unwanted effects depends on the dose and duration of use and indications for treatment.

Common, ADR> 1/100

tired, tired, headache, mild dizziness

dry mouth, solid phlegm

Constipation

Urinary retention

Eye regulatory disorders

Rare, ADR

Blood: Loss of granulocytes, leukopenia

circulatory: Reducing blood pressure, increasing heart rate

liver: Hepatitis jaundice due to cholestasis Kinh

Respiratory: The risk of respiratory suspension, even causing death suddenly encountered in children

Instructions on how to handle ADR

Foreign tower reaction:

The tower's non -tower reaction caused by phenothiazine usually divides the three main types: muscle tone increases reactions, feeling always moving (meaning lying, restless) and Parkinson's signs and symptoms.

Most patients with muscle -dysching disorders quickly respond to anti -Parkinson anti -cholinergic drugs (eg benzotropin, trihexyphenidyl) or with diphehydramine.

Signs and symptoms of restless sitting are usually automatically relieved. However, if this is uncomfortable, it is usually possible to control this condition by reducing the dose or simultaneously taking a anti -cholinergic anti -Parkinson, a benzodiazepam or propranolol.

Parkinson's symptoms are often controlled using combination of anti -Parkinson anti -cholinergic drugs. However, Parkinson's anti -Parkinson drugs are only used when it is necessary.

Malignant syndrome caused by sedatives can occur in patients using phenothiazine derivatives or other mental drugs. This foul is characterized by increased body temperature, severe algorithmic disorders (including musculoskeletal tone), loss of awareness at different levels (including lethargy and coma) mental state changes (including tone reducing reactions) and instability automatic nerves (including cardiovascular effects).

willow treatment of malignant syndrome is to stop phenothiazin immediately, symptomatic treatment and support treatment, water and electrolyte balance, cooling for patients and maintain kidney function, adjust cardiovascular disorders (stabilize blood pressure), prevent respiratory complications. There is currently no special treatment for this syndrome, although it is used the following drugs bromocriptin, amantadin, levodopha, etc. The agents of non -reducing neurotransmitter in some patients.

Warnings

Contraindicated

Do not use for people with liver or kidney dysfunction, epilepsy, Parkinson's disease, armoral disabilities, chromium cell tumors, myasthenia gravis, prostate hypertrophy.

Do not use for people who are sensitive to phenothiazin or have a history of an asthma angle or any ingredient of the drug.

Do not use for overdose caused by barbituric, opiat and alcohol.

Not used when leukemia, when there is a previous batch of granulocytes.

Not for children under 2 years old.

Precautions when using

Be cautious when used for the elderly, especially when the weather is very hot or very cold (causing risk of increasing or cooling). It is necessary to notify the patient to know the phenomenon of drowsiness during the first days of treatment and recommend that they should not control the car and machinery during the medication days. Elderly people are very susceptible to lower blood pressure.

Alimemazin can affect skin tests with allergens, avoid alcohol or other central neurological inhibitors.

The ability to drive and operate machinery

The drug can cause dizziness, so it is necessary to use carefully for drivers or operating machinery.

During pregnancy and breastfeeding

Pregnancy: There is a notice of Alimemazin causing jaundice, and the symptoms of the pagoda in children that the mother has used this drug during pregnancy. Alimemazin must be avoided for pregnant women, unless the physician is deemed necessary.

Breastfeeding period: Alimemazincc can excrete in tamarind milk, so do not use medication for mothers who are breastfeeding or have to stop breastfeeding during stopping the drug.

Drug interaction

The central neurological inhibitory effect will be stronger by: alcohol, barbituric and other sedatives. Respiratory inhibition also occurred when used in combination with these drugs.

The hypotension effect of anti -hypertension drugs, especially the alpha -adrenergic receptor blockers increases when using the lungs in accordance with phenothiazine derivatives.

The anti -cholinergic effect of phenothiazine increases when combined with other anti -cholinergic drugs, leading to constipation and heat.

anti -cholinergic drugs can reduce the anti -psychotic effects of phenothiazin.

Phenothiazine antagonists with therapeutic effects of amphetamine, levodopa, clonidin, guanethidin, adrenalin.

A number of drugs that prevents phenothiazine absorption is antacids, Parkinson, lithium medications.

Aliinemazin high dose reduces response to blood sugar factors. Do not use adrenalin for too much use of alimemazin.

Most of the above drug interactions are theoretical and often not dangerous.

Although most patients use lithium in combination with phenothiazin does not see harmful effects, there is a case of acute brain syndrome that occurred, especially when using high doses of lithium. Patients who use such combined drugs should be monitored with two nervous effects. Must stop treatment immediately if the symptoms appear.

When using phenothiazine in combination with levodopa, the anti -Parkinson effect of Levodopa may be inhibited due to the dopamine receptor in the brain. Levodopa is not effective in Parkinson's syndrome due to phenothiazin.

Storage

Where dry, no more than 30 ° C, avoid light.

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