ThioGamma 600 oral drugs treat diabetes sensory disorders (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Thioctic acid

Ingredient

Composition information	Content
Thioctic acid	600mg

Uses

Indications

thiogamma® 600 oral drugs are indicated in the following cases:

Treatment of sensory disorders caused by diabetic neuritis.

The hyperglycemia in diabetes is a result of glucose accumulation in the mother protein in the blood vessels and forming substances called the final products of the Glycosylation process (Ages: Advanced Glycosylation End Products). This process leads to a decrease in neurological blood flow and hypoxia/hemorrhagic hypoxia, in combination with the increase in the production of free oxygen roots, which is recorded in peripheral nerves due to decrease in antioxidants such as glutathion.

In mice studies, thioctic acid interacts with biochemical processes caused by mice with experimental diabetes caused by streptozocin through a decrease in the formation of Ages, improving neurological blood flow, increasing glutathione antioxidant levels and antioxidants for antioxidants for free oxygen roots in diabetic diabetes.

The observed results under the experimental conditions show that the function of peripheral nerve may be improved by the thioctic acid. This is related to sensory disorders in diabetic polyneuropathy can be manifested as sensory disorders, paresthesia such as hot, pain, numbness, cow senses.

Supplementing the previous clinical results in the treatment of symptoms of diabetes with diabetes with Thioctic acid, a central, controlled study with Placebo conducted in 1995 shows the beneficial effects of Thioctic acid found in symptoms of hot, simple, numb and painful symptoms.

pharmacokinetic

alpha - Lipoic acid (thioctic acid) is quickly absorbed after drinking. Absolute bioavailability (when compared to the intravenous) of Alpha - Lipoic Acid is approximately 20%. With the rapid distribution of the tissues in the body, the semi -cancellation time in the plasma of Alpha - Lipoic Acid in humans is approximately 25 minutes. The relative bioavailability of alpha acid - lipoic acid when used in solid form is 60% higher than the form of oral solution. The maximum concentration in plasma is approximately 4 µg/ml is measured about 0.5 hours after taking 600 mg of alpha - lipoic acid.

Using radioactive marking methods in animal tests (mice, dogs) shows that the excretory sugar is mainly through the kidneys, accounting for large quantities (80 - 90%) in the form of metabolites. Only a small amount of unchanged substances found in urine. Biological changes occur mainly due to oxidation chain cutting (p - oxidation) and/or s - methylation of taste.

on in vitro alpha - lipoic acid reacts with metal ionic complexes (as with cisplatin). Alpha - Lipoic Acid forms a hard -to -soluble complex with sugar molecules.

Before taking ThioGamma 600 oral drugs treat diabetes sensory disorders (3 blisters x 10 tablets)

How to use

Thiogamma drugs are taken orally.

Dosage

separate and daily dose.

Cases of sensory disorders are associated with diabetic polygon inflammation in adults

Daily dose is recommended as 1 tablet thiogamma® 600 oral (corresponding to 600 mg of Alpha - Lipoic Acid) orally about 30 minutes before breakfast.

Cases of serious sensory disorders, infusion therapy with alpha-lipoic acid can be conducted first

Methods and time of use:

Thiogamma® 600 oral tablets should take whole tablets with a sufficient amount of water when hungry. Food can reduce the absorption of the drug if used simultaneously. Therefore, patients need to keep hungry stomachs when taking the drug and the right time to take the medication is 30 minutes before breakfast. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

After intentionally or unintentionally drink large amounts of 10 to 40 g alpha - lipoic acid accompanied by alcohol, severe poisoning and sometimes deadly cause. Signs of clinical poisoning can be first manifested in mental disorders or consciousness disorders, and typically develop general seizures and lactic acid infections. In addition, reducing blood glucose, shock, globulin muscle melting blood, thrombosis of scattered vessels (dic), bone marrow weakness and multi -organ failure have been described as a result of high doses of alpha - lipoic acid.

Treatment opinions in case of overdose

In case of suspicion of severe poisoning caused by Alpha - Lipoic Acid (such as a dosage> 10 tablets 600 mg in adults and> 50 mg/kg of weight in children) immediately takes patients to medical agencies with basic emergency conditions of poisoning cases (such as causing vomiting, gastric wash, activated charcoal, etc.).

Treatment of general seizures, lactic acid infections and other life -threatening consequences of poisoning should be done with modern supporting care principles and need symptom treatment. Benefits of hemorrhage and peritoneal fertilizer or filtering methods to eliminate thioctic acid do not give solid results.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using the thiogamma® 600 oral drug, you may experience unwanted effects (ADR).

Symptoms on gastrointestinal

Nausea, vomiting, stomach pain - intestines and diarrhea.

Allergic reactions such as rash, urticaria and itching.

Nervous system disorders

Change and/or taste disorders.

Other undesirable reactions

Because sugar consumption can improve in diabetes patients, hypoglycemia may occur. Symptoms similar to hypoglycemia have been described as dizziness, sweating, headache, visual transformation.

Notify the doctor with unexpected effects when taking the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

thiogamma® 600 oral drugs in the following cases:

thiogamma® 600 oral is absolutely contraindicated in patients who know how to be sensitive to alpha - lipoic acid or any ingredients of the drug.

Note: Because there is no research in children and adolescents, do not use thiogamma® 600 oal with these objects.

Be cautious when using

Patients with non -tolerant fructose in genetic, poorly absorbent glucose - Galactose or Saccharase - Isomaltase deficiency should not use thiogamma® 600 oral.

The ability to drive and operate machinery

does not affect.

Pregnancy

in accordance with the principles of pharmaceutical use, the product should only be used for pregnant women after careful consideration of the ratio between benefits and risks.

Pregnant women should treat with acidCtic acid only when they have followed in accordance with the instructions of the physician, even if the toxicity studies for the reproductive system do not give any results affecting fertility and embryo development and no signs showing fetal toxicity.

The period of breastfeeding

In accordance with the principles of using pharmaceuticals, the product should only be used for breastfeeding women after careful consideration of the ratio of benefits and risks.

Women who breastfeed should be treated with thioctic acid only when they follow the instructions of the physician.

It is unknown whether alpha - lipoic acid is secreted into human milk or not.

Medicinal interaction

Cisplatin's loss of effect when used simultaneously with thiogamma® 600 oral.

Alpha - Lipoic Acid is a metal complex and so should not be used simultaneously with metal compounds (such as iron, magnesium, dairy products containing calcium). If thiogamma® 600 oral is used daily 30 minutes before breakfast, iron and magnesi products can be used at noon or afternoon.

Hypoglycemic effects may occur in combination with insulin or other diabetes treatments. Therefore, it is necessary to monitor blood sugar closely, especially in the early stages of alpha-lipoic acid therapy. In special cases, reducing insulin or oral diabetes treatment drugs is necessary to prevent the manifestations of hypoglycemia.

Note: Regular use of alcohol is a high risk agent for the development and growth of neurological diseases, and thus reduces the success of treatment with Thiogamma® 600 oral. Therefore, patients with diabetic polygonary infections should be recommended to avoid alcohol. This also needs to be recommended for the time of untreated time.

Storage

Store at temperatures below 25 ° C.

Avoid light.

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