Thioridazin 50mg Danapha treat schizophrenia (100 tablets)

Dosage form Box of 100 capsules
Specifications Thioridazine

Ingredient

Composition information	Content
Thioridazine	50mg

Uses

Indications

Thioridazin 50 mg is indicated in the following cases:

Treatment in schizophrenia does not respond to other psychotic drugs.

The drug has an antagonistic effect dopamine, specifically the D2 - dopamine receptor blockers in the black sickles, the funnel, between the shell and the middle of the brain.

In addition, the dopamine receptor of the onion and the front part of the brain.

pharmacokinetic

absorption

Thioridazin is quickly absorbed through the gastrointestinal tract. The peak concentration in plasma is achieved after drinking for 2-4 hours.

Distribution

Pigments attached to plasma proteins (95%).

Metabolism

The drug is metabolized in the liver into active metabolites (mesoridazin, sulforidazin).

Elimination

T1/2 is about 21 hours. Excretion is mainly in stool and partially through both intact form and active metabolites. Thioridazin passes the placenta and excreted in breast milk.

Before taking Thioridazin 50mg Danapha treat schizophrenia (100 tablets)

How to use

Thioridazin is taken orally.

Dosage

Because Thioridazin has the ability to extend the QT range, which can be life -threatening, so the dosage must be effectively used in each patient.

Adults

Starting dose for schizophrenia patients: 50 - 100 mg x 3 times/day, increasing to a maximum dose of 800 mg/day if needed. When achieved treatment effect, reduce the lowest dose to the lowest dose effectively. Total daily dose is about 200 - 800 mg divided into 2-4 times.

Children

usually 0.5 mg/kg/day, gradually increasing to optimal dose effectively or up to 3 mg/kg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Poisoning concentration is about 1 mg/dl, death concentration 2 - 8 mg/dl.

Symptoms

On the heart: arrhythmia, hypotension, shock, ECG change, extend QT, slow rhythm, fast sinus rhythm, atrial block.

On the digestive system: constipation, intestinal obstruction.

Monitor abnormal heart rate for timely handling. The treatment includes: abnormal adjustment of electrolytes, acid imbalance - base, can use lidocaine, phenytoin, isoproterenol.

Consider gastric lavage and use activated carbon. Do not recommend vomiting because it can cause muscle disorders and inhalation of vomiting.

Symptoms of extracurricular treatment with: diphenhydramin hydrchlorid or benztropin mesylate.

Increase the urinary tract, hemolytic, do not use Barbiturar to treat convulsions because it can cause respiratory failure.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using Thioridazin 50 mg , you may experience unwanted effects (ADR).

Central nerve: Drowsy, especially when high doses in the first stage of treatment.

Plant nerves: dry mouth, blurred vision, constipation, nausea, vomiting, diarrhea, stuffy nose, pale.

Endocrine system: Increasing milk secretion, breast tension, amenorrhea, inhibiting ejaculation, peripheral edema, menstrual disorders . Skin: Dermatitis, rash due to urticaria, light sensitivity. blood disorders: leukemia, leukemia, hypoclower, anemia, immune system reduction. allergic reactions: fever, larynx, pulse edema, asthma.

Liver poisoning: jaundice, bile stasis.

Syndrome syndrome: Sitting restless, excited, restless, crooked neck, tremor, stiff muscle.

Cardiovascular: extends the QT range.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Thioridazin 50 mg contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Children under 1 year of age.

Concomitant use with drugs that extend QT or patients with congenital QT syndrome.

Concentrated use of Cytochrom P450 2D6 inhibitors such as fluoxetin, paroxetin or other drugs inhibitors inhibitors of thioridazin metabolism (fluvoxamin, propranolol and pindolol).

The coma, the central nervous system is severely inhibited or is taking other TKTW inhibitors.

Cardiovascular disease is severely caused by hypertension or hypotension.

Precautions when used

Caution in patients with leukopenia or leukemia, seizures, convulsions. In schizophrenia patients with epilepsy should maintain anti -convulsions during treatment with thioridazin.

Pig pigeitis is reported in patients with a dose larger than the recommended dose, symptoms: Reduction of vision, night vision reduction, symptoms that can be reduced when given the recommended dose.

Women's patients are at higher risk of hypotension than male patients. Do not use epinephrin to treat hypotension caused by drugs because it can reverse the effect of epinephrin.

Thioridazin can cause drowsiness, hypotension standing, feeling unstable, may fall fracture or other injuries. For patients with disease or taking this drug, it can be worse than this effect should be assessed before treatment with psychotic drugs or periodically with prolonged anti -psychotic therapy.

The ability to drive and operate machinery

Caution when used for people who are driving or operating machinery because the drug can cause sleep, dizziness.

Pregnancy

Children exposed to anti -psychotic drugs in the last 3 months of pregnancy are at risk of outsourcing of extracurricular syndrome and/or have postpartum cessation syndrome. There have been reports of agitation, reducing muscle tone, tremor, sleeping, weakness, eating disorders in this infant.

Do not use special in the first 3 months of pregnancy, only medication when considering benefits and risks.

Breastfeeding period

thioridazin excreted in milk, so breastfeeding women should not use.

Medicinal interaction

Cytochrome p450 2d6 inhibitors such as fluoxetin, paroxetin or substances that reduce the activity of this isoenzyme: increase the concentration of Thioridazin.

Thiniidazine elimination drugs through other metabolic paths: fluoxamine, propanolol, pindolol .

The drug extends the QT interval: Do not coordinate.

Alcohol, anesthetic, barbiturat, opiat, other sedatives: Increases the inhibitory effect on the nerves.

Storage

In a dry place, avoid light, the temperature does not exceed 30ºC.

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