Tinidazol 500mg Domesco prevent infection after surgery (1 blister x 4 tablets)

Dosage form Box of 1 blister x 4 tablets
Specifications Tinidazole

Ingredient

Composition information	Content
Tinidazole	500mg

Uses

Indications

Tinidazol 500mg is indicated in the following cases:

Tinidazol often coordinates with other antibiotics in the following cases:

Preventive:

Infections after surgery due to anaerobic bacteria, especially infections related to Dai Trang, stomach and gynecological surgery.

Treatment:

Bacterial infections in the abdomen: Vectoritis , abscess. lungs. Metronidazol. The drug works with both virgin animals and mandatory anaerobic bacteria such as Bacteroides spp., Clostridium spp., Fusobacterium spp.

The mechanism of the effect of Tinidazol with anaerobic and animal bacteria is a drug penetrating the cells of microorganisms and then destroying the DNA chain or inhibiting DNA synthesis.

Tinidazol has the effect of preventing and treating bile or gastrointestinal infections, treating abscesses and treating anaerobic infections such as necrotic balancing and steam gangrene. In fact, mixed bacterial infections, so it is necessary to coordinate Tinidazol with other antibiotics appropriately to be able to eliminate bacteria when suspected. To prevent infections in surgery, tinidazol can be combined with gentamicin or tinidazol with cephalosporin, used before and during surgery. Do not use medication after surgery.

Preventive drug use does not increase preventive effects, but also increases the risk of hidden bacterial infections and drug resistance. If there is a suspected anaerobic and Enterococcus mixture, Tinidazol should be combined with both gentamicin and ampicillin/cephalosporin, or Tinidazol with Vancomycin. In case of suspected infection of Gram -negative bacteria of enterobacteriaceae such as Klebsiella, Proteus or Escherichia along with anaerobic bacteria, should coordinate Tinidazol with cephalosporins 1 or 2.

If there is suspicion of other Enterobacteriaceae bacteria such as Enterobacter, Morganella, Providencia Serratia in anaerobic and aerobic infections, tinidazol should be coordinated with 3rd generation cephalosporin, penicillin and beta-lactamase inhibitors, monobactam or Gentamicin. If you suspect metronidazol/tinidazole anaerobic bacteria can use other alternative drugs such as clindamycin or chloramphenicol impenem or penicillin and beta - lactamase inhibitors.

pharmacokinetics

Tinidazol is absorbed most after drinking and especially the peak concentration in plasma reaches about 40microgam/ml after 2 hours of using a single dose of 2g, dropped to 10microgam/ml after 24 hours and 2.5microgam/ml after 48 hours. With a daily maintenance dose of 1g can maintain concentration of 8microgam/ml. The equivalent dose, used by intravenous line, also gives similar plasma concentrations such as oral dose. Half lifetime elimination in plasma is 12 - 14 hours.

Tinidazol is widely distributed and concentrations achieved in bile, milk, cerebrospinal fluid, saliva and other tissues in the body are similar to plasma concentrations, the drug is easy through the placenta. Only 12% attached to plasma proteins. The drug has not metabolized and the metabolites of the drug are excreted in the urine and partly in the feces.

Before taking Tinidazol 500mg Domesco prevent infection after surgery (1 blister x 4 tablets)

How to use

Tinidazol 500mg Used orally at a single dose during or after eating.

Dosage

Tinidazol is often taken orally at a single dose during or after eating.

Used as directed by the physician or the following dose:

Preventing infections after surgery: Adults take 2g dose of 12 hours before surgery. Usually treated for 5 - 6 days.

Adults

single dose 2g. At the same time treat both spouses.

Children

The only dose of 50 - 70 mg/kg body weight.

Giardia infection

Adults: single dose 2g, drink once.

Children: The only dose of 50 - 75mg/kg, drink once, can use a dose to repeat, if necessary.

Amoeba infections in the intestine

Adults: 2g dose.

Children: use the dose of 50 - 60mg/kg body weight/day, take 3 consecutive days.

liver amoeba

Adults: Take 1.5 - 2g, for 3 - 6 days.

Children: 50 - 60mg/kg body weight/day, for 5 consecutive days.

Note:

Cases of use in combination with other antibiotics to treat mixed bacterial infections. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist. Mainly treat symptoms and support; Gastric lavage, possibly eliminating Tinidazol easily with a separation.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Tinidazol 500mg , you may experience unwanted effects (ADR).

There are about 3% of patients treated with unwanted reactions.

Common, ADR> 1/100

circulatory: thrombosis, pain in the injection place.

Digestive: Nausea, not delicious, abdominal pain.

Other reactions: Test taste change.

Uncommon, 1/1000

Body: Dizziness, headache.

digestive: vomiting, diarrhea .

Rare, ADR

Systemic: allergies, fever.

Blood: Reducing leukocytes. digestive: stomatitis.

Skin: Outdoor, itching, skin rash.

Muscle muscle: joint pain.

nerve: peripheral neuropathy.

Urinary urine: Dark urine. Occasionally there is a mixed allergic reaction: foreign rash, urticaria accompanied by fever and joint pain. A few cases of air conditioning and convulsions have also been notified.

Instructions on how to handle ADR

Stop treatment if you see abnormal nerve signs.

Treatment of reactions like Disulfiram is mostly symptomatic and supportive treatment.

Although most of these reactions are often out of self -life and life -threatening, treatment should be treated at a place where vehicles and emergency drugs should be available, because of severe arrhythmia and hypotension sometimes occur. Oxygen or 95% oxygen and 5% carbon dioxyd mixture can be used to support respiration. Can handle heavy reactions like the case of shock. Can use electrolytes or plasma solutions to maintain circulation.

Notify the doctor the unwanted side effects when using the drug.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Tinidazol 500mg contraindicated in the following cases:

Sensitive to any ingredients of the drug.

Hematopoiia or a history of porphyrin metabolism.

The first three months of pregnancy, nursing women.

Patients with physical neurological disorders.

Be cautious when using

during treatment with Tinidazol should not use alcohol preparations because there may be the same reaction as Disulfiram (flushed, abdominal spasms, vomiting, fast heartbeat).

Cases of use in combination with other antibiotics to treat mixed infections.

The ability to drive and operate machinery

Tinidazol can cause drowsiness so it is necessary to use the drug for trainers and operate machinery.

Pregnancy

Tinidazol through the placenta fence. Contraindicated to use this drug for pregnant women in the first 3 months and unknown effects of these drugs on the fetus. There is no evidence Tinidazole is harmful in the later period of pregnancy, but it is necessary to consider the benefits of medication and the possibilities that are harmful to the fetus and the mother in the second and third three months of pregnancy.

Breastfeeding period

Tinidazol excreted through breast milk. After 72 -hour medication, Tinidazol may still be found in milk. Do not use for breastfeeding mothers, or only breastfeeding for at least 3 days of stopping the drug.

Medicinal interaction

cimetidine can reduce the elimination of Tinidazol from the body. Perhaps due to cimetidine inhibits the metabolism of Tinidazole in the liver, increasing both treatment and toxic effects.

rifampicin may increase the release of Tinidazol. Maybe due to increased metabolism Tinidazol in the liver, and reducing the treatment effect.

Storage

In a dry place, avoid light, at temperatures below 30 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.