Tipha-C 1000mg tipharco effervescent tablets treat vitamin C (10 blisters x 2 capsules)

Dosage form Box of 10 blisters x 2 tablets
Specifications Acid ascorbic

Ingredient

Composition information	Content
Acid ascorbic	1000mg

Uses

Indications

tipha c indicated for treatment of vitamin C deficiency.

Pharmacology

Pharmacological group: Water -soluble vitamins

ATC code: A11ga01

Vitamin C is a water -soluble vitamin, necessary to synthesize collagen and components of connective tissue. The deficiency of vitamin C occurs when the food provides not enough vitamin C needed, leading to Scorbut.

Ascorbic acid has the ability to reduce in many oxidative - redox biological reactions. There are some biological functions of ascorbic acid that have been clearly defined, including collagen biosynthesis, carnitin, catecholamine, tyrosin, corticosteroids and aldosteron. Ascorbic acid has also participated as a reducing agent in the drug metabolic enzyme system along with Cytochrom P450.

The activity of this drug metabolic enzyme system will be reduced without ascorbic acid. Ascorbic acid also regulates absorption, transportation and reserves of iron.

Ascorbic acid is an effective antioxidant protection. Ascorbic acid immediately removes oxygen, reaction nitrogen (ROS = ROCTIVE OXYGEGE SPECIES and RNS = Reactive Nitrogen Species) such as hydroxyl, Peroxyl, Superoxid, Peroxitrit and nitroxid), free oxygen and hypoclorides, are toxic radicals for the body. There are many biological evidence proving that free radicals at high concentrations can damage cells. Some chronic diseases are associated with oxidative stress damage including cancer, cardiovascular disease (coronary atherosclerosis ...), cataracts, asthma and chronic lung disease. However, at present, it has not clearly identified the cause of the cause.

In vitro, ascorbic acid has shown to prevent LDL oxidation by removing ROS and RNS in the water environment. Oxidation LDL is thought to cause atherosclerosis.

Ascorbic acid in white blood cells is especially important because ROS arises during macrophages or active leukocytes due to inflammation. High ascorbate concentration in leukemia protects leukemia against oxidation damage without inhibiting the bactericidal activity of the microbiological body. The antioxidant activity of ascorbic acid also protects against protein breakdown in inflammatory positions such as joints (low inflammation), lungs (respiratory failure syndrome in adults, smoking, ozone).

Particularly for colds, so far the data has not been the most crowded to advise. In addition, there are several evidence of ascorbic acid that can synthesize protaglandin synthesis for bronchodilator, vasodilator and anticoagulants, the ability to convert folic acid into folinic acid, carbohydrate metabolism, lipid synthesis, protein, resistance and cell respiration.

Dynamic pharmacokinetics

absorption

Vitamin C is easily absorbed after drinking; However, absorption is a positive process and may be limited after huge doses. Provide regular amount of vitamin C through diets from 30 - 180 mg daily, about 70 - 90% absorbed. At the dose over 1 g
daily, the absorption decreases to about 50% or less. In normal human research, only 50% of a dose of 1.5 g vitamin C is absorbed. Vitamin C absorption in the stomach - intestines may be reduced in diarrhea or gastric disease.

Normal vitamin C concentration in plasma is about 10 - 20 micrograms/ml. Plasma concentrations below 1 - 1.5 micrograms/ml when scorbut disease. The total amount of vitamin C reserved in the body is estimated at 1.5 g with about 30 - 45 mg, which is circulated
daily. Clinical signs of Scorbut disease often become clear after 3-5 months of vitamin C deficiency.

distribution

Vitamin C is widely distributed in body tissues. High vitamin C levels are found in the liver, leukocytes, platelets, gland tissue and lens of the eye. About 25% of vitamin C in plasma combined with protein.

Ascorbic acid passes through the placenta and distributed in breast milk.

Elimination

Acal acid ascorbic oxidizes reversible into dehydrooscorbic acid. A little vitamin C converted into non -activity compounds including ascorbic acid - 2 - sulfate and oxalic acid excreted in urine. There is a threshold of eliminating ascorbic acid through the kidneys about 14 micrograms/ml, this threshold may vary depending on each person. When the body saturated ascorbic acid and blood concentration beyond the threshold, ascorbic acid is unchanged and eliminated into the urine. This is the basis for Ascorbic acid saturated test for vitamin C nutrients. When saturated in tissue and ascorbic acid level in low blood, ascorbic acid eliminates little or does not eliminate into the urine. Ascorbic acid can be removed by hemolysis.

Before taking Tipha-C 1000mg tipharco effervescent tablets treat vitamin C (10 blisters x 2 capsules)

How to use

Tipha c medicine in the form of oral tablet.

Dosage

The usual dose:

Adults: 1 capsule/day until symptoms are improved. The maximum dose must not exceed 1 tablet/day. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Treatment: Diuretic by infusion may work after a large dose.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using tipha C often increases oxalate urinary tract, nausea, vomiting, heartburn, abdominal spasms, fatigue, redness, headache, insomnia and drowsiness have occurred. After taking the dose of 1g daily or larger, diarrhea may occur.

Common, ADR> 1/100:

Kidney: Increase oxalate.

Blood: Hemolytic anemia How to handle ADR:

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Tipha c drugs in the following cases:

People with oxalate stones.

Caution when using

Causes need to be cautious:

Using vitamin C at this content can lead to greasy phenomenon, so when reducing the dose will lead to a deficiency of vitamin C. Large doses of vitamin C during pregnancy leading to scorbut disease in infants.

Increased oxalate oxalate and the formation of calcium oxalate stones in the kidneys may occur after high doses of vitamin C, should be avoided in this content for patients with calcium oxalate stones in the kidneys, if necessary, should closely monitor oxalate urine. Vitamin C can cause acidification of urine, sometimes leading to urate or cystin precipitate, or oxalate stones, or medications in the urinary tract.

Excessive use and prolonged preparations containing vitamin C can cause enamel corrosion.

Using vitamin C can falsify the results of glucose test in urine (fake positive when using copper sulfate reagent or fake negative when using glucose oxidase method).

Taking high doses of vitamin C for a long time can cause dangerous heart disease in people with high iron reserves or people infected with tissue.

can cause hemolysis in infant deficiency Glucose-6-phosphate dehydrogenase.

Some preparations containing Aspartam are substances converted into phenylalanin, not used in patients with phenylketon urine. Some preparations containing excipients can cause allergies.

Use carefully with people with a history of kidney stones, oxalate oxalate and standard oxalate chemical disorders (increased risk of kidney stones), thalassemia disease (increased risk of iron absorption).

High doses, prolonged for pregnant women.

Use drugs for pregnant or lactating women

Pregnancy: Ascorbic acid passes through the placenta, the blood concentration in the umbilical cord is 2 to 4 times the concentration of the mother's blood. If you use vitamin C according to normal needs, there is no problem on people. However, taking large amounts of vitamin C during pregnancy can increase the need for vitamin C and lead to scorbut disease in infants.

Breastfeeding period: Ascorbic acid is distributed in breast milk. Mother's milk has a normal diet containing 40 - 70 micrograms of vitamin C/ml, no problem has happened to babies.

The effect of drugs on driving, operating machinery

The drug can cause headaches, insomnia, sleep that should not be used for operators, driving train.

Medicinal interaction

Simultaneously used in the ratio of over 200mg of vitamin C with 30mg of elemental iron that increases iron absorption through stomach - intestines.

Simultaneous use of vitamin C with aspirin increases the secretion of vitamin C and reduces aspirin secretion in urine. Salicylate inhibits leukocytes and platelets to absorb ascorbic acid. Therefore, ascorbic acid levels in leukemia and in plasma are reduced, only slightly higher than the concentration of
people with Ascorbic acid deficiency in tissue.

Simultaneous use of Vitamin C and Fluphenazin leads to a decrease in plasma fluphenazin levels.

The acidification of urine after using vitamin C can change the excretion of other drugs.

Vitamin C high doses can destroy vitamin B12; It is necessary to advise patients to avoid high doses of vitamin C within an hour before or after taking vitamin B12.

Vitamin C can reduce the absorption of selenium (drink at least 4 hours apart).

Vitamin C can increase the effects of hydroxyd aluminum and reduce the effect of amphetamine.

Because vitamin C is a powerful reducing agent, it affects many tests based on oxidation - reducing reactions. The presence of vitamin C in urine increases the amount of glucose if quantitative with copper reagent (II) sulfate and false reduction of glucose amount if quantitative
by glucose oxydase method. With other tests, it is necessary to consult a specialized document on the effects of vitamin C.

There are several vitamin C reports that reduce wet coagulation effects, but not sure.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

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