Tobicom ICA supports the treatment of eye fatigue, soreness (3 packs x 6 blisters x 10 tablets)

Dosage form Hard capsules
Specifications Box of 18 blisters x 10 tablets
Ingredient Sodium chondroin sulfate, choline, retinol, riboflavin, thiamin hydrochloride
Indication Eye fatigue, night blindness, keratitis, blurred vision

Ingredient

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Composition information	Content
Sodium chondroitin sulfate	100mg
Choline	25mg
Retinol	2500iu
Riboflavin	5mg
Thiamin hydrochlorid	20mg

Uses

Indications

Tobicom® drugs are indicated in the following cases:

Treatment of eye fatigue, eye pain, night blindness. Maintain the elasticity of contact lenses.

Cholin Bitartrat, Retinol Palmitat, Thiamin Hydrochorid and Riboflavin are the substances needed for the development and maintenance of epithelium, restoring visual function, protecting cornea and preventing eye aging.

pharmacokinetics

Vitamin A

Fast absorption through the gastrointestinal tract but the absorption is reduced in people with poorly absorbing fat, eating less protein or liver or pancreatic function. Some retinols are stored in the liver. The retinol part that is not stored in the liver will match with glucuronic acid and then oxidize into retinal and retinoic acid. These substances, along with metabolites, are eliminated in urine and feces. Vitamin A does not pass the placenta but is present in breast milk.

thiamin

After drinking, a small amount of thiamin is well absorbed through the gastrointestinal tract. However, the absorption is limited at a dose higher than 5 mg. Thiamin distributes most of the tissues in the body, and is present in breast milk. In cells, Thiamin exists mainly in the form of diphosphate. Thiamin hardly reserved in the body. When absorbed beyond the body's demand, the excess amount will be eliminated through the urine in the form of non -guava or metabolic.

riboflavin

easily absorbed through the gastrointestinal tract. Although Riboflavin is widely distributed throughout the body's tissues, the amount of drugs stored in the body is negligible. In the body, Riboflavin is transformed into Coenzyme Flavin Mononucleotide (FMN; Riboflavin 5 ' - Phosphate) and then into another coenzym, Flavin Adenine Dinucleotid (FAD). About 60 % FMN and FAD are attached to plasma proteins. Riboflavin is excreted in urine, partly in the form of metabolites. When increasing the dose, large amounts of drugs are discharged in constant form. Riboflavin has passed the placenta and distributed into breast milk.

sodium chondroin sulfate

Used by oral, plasma peak concentration is achieved after 6-8 hours and maintains the concentration of detection in 24 hours, 50% - 60% is excreted in the urine in the form of mucopolysaccharid, a component of cartilage tissue in mammals.

Before taking Tobicom ICA supports the treatment of eye fatigue, soreness (3 packs x 6 blisters x 10 tablets)

How to use

Tobicom drugs are taken orally.

Dosage

1 capsule, 1-2 times/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? When these symptoms occur, stop the drug and consult a doctor or pharmacist.

Together with vitamin A

Chronic poisoning

For prolonged high doses of vitamin A can lead to vitamin A. The characteristic symptoms are: fatigue, irritability, blankets, weight loss, vomiting, digestive disorders, fever, liver - Spleen, changing skin, hair loss, dry hair, chapped lips and bleeding, headache, high blood calcium, edema under the skin, pain in bones and bones. stretching), eyelid edema, tinnitus, visual disorders, painful swelling along the long bones. When stopping vitamin A, the symptoms also gradually disappear, but the bone may stop growing because the long bone heads have been reinforced too early.

Acute poisoning

Take Vitamin A very high doses leading to acute poisoning with signs of drowsiness, dizziness, loss of flowers, nausea, vomiting, prone to irritation, pain, delusion and convulsions, diarrhea. Symptoms appear after drinking from 6 to 24 hours.

Handling

Must stop taking the drug. Symptomatic treatment and supportive treatment.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Tobicom®, you may experience unwanted effects (ADR).

sodium chondroin sulfate

Common, ADR> 1/100

Without information.

Rare, ADR

Digestive system: Nausea, vomiting, diarrhea, mild stomach pain.

The presence of cholin can cause trimethamine ureter (or fish smell syndrome) in patients with an enzyme deficiency of trimethylamine metabolism - n - oxide.

Retinol Palmitat (Vitamin A)

Harmful side effects and effects will appear when taking high doses of high doses or when taking a very high dose of vitamin A (see the overdose of vitamin A).

riboflavin

There is no unwanted effect when using riboflavin. Using high doses of riboflavin, the urine will turn light yellow, causing deviations to some urine tests in the laboratory.

thiamin hydrochloride

The harmful reactions of Thiamin are very rare and often allergic. Hypersensitivity reactions occur mainly when injecting.

Normally, thiamin enhances acetylcholin effects, some skin reactions can be considered as an allergic reaction.

Common, ADR> 1/100

Without information.

Rare, ADR

Systemic: Sweating, hypersensitivity.

Circulation: Acute hypertension.

Skin: skin, itching, urticaria.

Respiratory: Difficulty breathing.

Instructions on how to handle ADR

Notify the doctor of side effects, if any, when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Tobicom® drugs contraindicated in the following cases:

Hypersensitivity to one of the ingredients of the drug.

Do not use the same drugs containing vitamin A.

Precautions when using

Follow the right dose and usage.

In children, taking medicine under the supervision of adults.

Keep pills out of reach of children.

Do not use vitamin A more than 5000 IU per day because vitamin A is also provided from daily food.

Patients who are being treated with other drugs or pregnant women should consult a doctor or pharmacist before taking the drug.

The ability to drive and operate machinery

No information.

Pregnancy

Pregnant women should consult a doctor or pharmacist before taking the drug.

Recommendation: Avoid using vitamin A exceeding 5000 IU (international unit) every day for pregnant women because of the ability to give birth.

Breastfeeding period

No information.

Drug interaction

Sodium Chondroitin Sulfate

chondroitin increases the anticoagulant effects of anticoagulants (warfarin). This can cause serious bleeding, so it should not be taken when taking warfarin.

cholin hydrotartrat

Cholin in combination with vitamins B6, B12 and Folic acid plays a role in homocysteine metabolism. Methotrexate reduces Cholin's metabolites when used with this drug, whereas research on mice also shows cholin that reduces the liver fattyness caused by methotrexate.

Retinol Palmitat (Vitamin A)

neomycin, cholestyramin, liquid paraffin reduces vitamin A absorption.

Oral contraceptives may increase vitamin A concentration in plasma and have an unfavorable effect on conception. This explains why sometimes the possibility of conception is reduced in time right after stopping the use of steroids.

Vitamin A and Isotretinoin simultaneously can lead to an overdose of vitamin A. It is necessary to avoid using the two above drugs such as avoiding high doses of vitamin A.

riboflavin

Meet a number of "lack of riboflavin" in people who used clepopromazin, imipramin, amitriptylin and adriamycin.

Wine can hinder the absorption of riboflavin in the intestine.

Probenecid used with riboflavin causes reduced absorption of riboflavin in the stomach, intestines.

thiamin hydrochloride

Thiamin may falsify a number of tests (including blood uric acid tests, urinary urinary urin). Therefore, it is necessary to notify your doctor and your treatment doctor when using this vitamin.

Other interactions

In the ingredient of DL - Alpha Tocopherol (Vitamin E). Vitamin E reduces the effectiveness of vitamin K and increases the effectiveness of anticoagulants.

Simultaneous use of vitamin E and acetylsalicyclic acid is at risk of bleeding.

Vitamin E can increase the absorption, use and storage of vitamin A. Vitamin E protects vitamin A from oxidation due to oxidation, causing the level of vitamin A in cells to increase; Vitamin E also protects against the effects of excess vitamin A. However, these effects are still arguing.

Storage

Keep a cool dry place (below 30 ° C), avoid light.

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