Toganin 500 longevity Pharma treatment for hyper ammonia blood, indigestion disorders (12 blisters x 5 tablets)

Arginin, such as other amino dibasic acids, stimulates the pituitary glands to release growth hormones and prolactin, pancreas release glucagon and insulin.

arginin is a major amino acid in the urea cycle in patients with N-acetylglutamate Synthase (NAGS), Carbamyl Phosphate Synthetase (CPS), Okithin Transcarbamylase (OTC), ArginoSucaneinat Synthase (ASS), or ArginininoSucInat Lyase (ASL).

Use Arginin hydrochloride in patients with these disorders that restore arginin concentration, which helps prevent protein catabolism. Intravenous infusion for patients with ASS or ASL deficiency has the effect of promoting ammonia consolidation into citrullin and areinininosuceinat. These intermediate products of the urea cycle are less toxic and easier to excrete in urine than ammonia and provide a series of biochemical reactions to eliminate nitrogen waste.

arginine increases blood glucose levels. This effect may be directly. Glycogen decomposition and new glucose creation can also be through arginin intermediaries stimulating glucagon release.

The serum gastrin concentration is enhanced by arginin. The drug inhibites the recovery of the renal tubules and thus increases the excretion of the protein in the urine including albumin, light chain Immunoglobulin and beta2 microglobulin.

Dynamic pharmacokinetics

arginin hydrochloride absorbed well through the gastrointestinal tract. The peak concentration in plasma is achieved after about 2 hours. Absolute 70%bioavailability.

After intravenous infusion, Arginin's peak concentration is achieved at 20-30 minutes after the beginning of the transmission.

Arginin hydrochloride is combined with many biochemical reaction processes. Strong metabolic drugs in the liver, forming Ornithine Urea through the hydrogen subdivision of Guanidin under the catalyst of Arginase. Arginin is filtered in the renal tubules and is absorbed almost completely in the renal tubules.

Half lifetime elimination: 1.2 - 2 hours.

Medicinal allergies, erythema and swelling in the hands and face decrease rapidly after stopping the drug and using diphenhydramin.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Do not use arginin hydrochloride for patients with atopic allergies. Antihistamine drugs are used if allergic reactions occur. Arginin hydrochloride causes hyperkalemia to threaten life for patients with renal impairment because the excretion of potassium decreases in these patients. Arginin should be used with care for patients with kidney or anuria.

For acute hyperactive hyperglycemia, high doses of arginin can cause an acid to metabolize hypertension, so it is necessary to monitor the concentration of chloride and bicarbonate in plasma and can simultaneously use a suitable amount of bicarbonate.

Because arginin contains high levels of nitrogen that can be metabolized, before taking the drug, it must be an evaluation of a temporary effect on the kidneys of the high amount of nitrogen.

Do not use Arginin for patients after myocardial infarction.

The effect of the drug on the ability to drive and operate machinery

The drug does not cause drowsiness so it does not affect the ability to drive and operate machinery as well as work.

Use drugs for women during pregnancy and lactation

Pregnant women:

There is no complete and well -verified research on the use of arginin in pregnant women, so they do not use this drug for women during pregnancy.

breastfeeding women:

It is unknown whether the arginin is secreted in a significant amount in human milk or not. It is necessary to consider the benefits of treatment with drugs and the risk of fetus to decide the use of drugs and stop breastfeeding.

Interactive drug

Estrogen and progesterone combined oral drugs may increase the response of growth hormones and reduce the response of glucagon and insulin with arginin.

Insulin concentration in plasma after arginin stimulation can be increased by thiazid, xylitol and aminophylin diuretics. The following two drugs also reduce the response of glucagon with arginine. For a long time, Sulfonylurea, an oral diabetes, can prevent glucagon response in plasma with arginin, when patients do not tolerate glucose intolerant to glucose.