Tomax Genta Detapharm skin cream for allergic skin (6g)

Dosage form Tube x 6g
Specifications Clotrimazole, Triamcinolone, Gentamicin

Ingredient

Composition information	Content
Clotrimazole	0.06
Triamcinolone	0.006
Gentamicin	0.006

Uses

Indications

Tomax Genta drugs are indicated in the following cases:

Eczema (Eczema, dermatitis, etc.).

Tomax Genta is a on -site, broad spectrum. There is a combination of 3 main active ingredients: clotrimazol, triamcinolon acetonid, gentamicin sulfate. With pharmacological properties as follows:

Clotrimazol: A broad -spectrum antivirus drug used to treat skin diseases caused by different types of fungus and also work on Trichomonas, Staphylocus and Bacteroides. There is no effect on lactobacili. Clotrimazol is linked to phospholipids in the fungal cell membrane, changing the absorbent of the membrane, causing loss of intracellular essential substances that lead to the destruction of mushroom cells. Invitro, Clotrimazol have the effect of restraining and killing fungi. Depending on the concentration, with Trichophyton Rugbrum, Trichophyton Mentagrophytes, Epidermophyton Floccosum, Microsporunrcanis and Candida species. Natural resistance with rare clotrimazol.

triamcinolon acetonid is a substance of the corticoide family that has anti -inflammatory effects through a variety of different mechanisms. It has the effect on the multiplication receptor to inhibit the generation of many cells and many factors present in the inflammatory process of the chest, thus reducing the release of vascular and dynamic movements, reducing the secretion of tissue and protein pepper, reducing leukemia in damaged areas, and eventually reducing fiber chemistry. All lead to reducing inflammation.

Gentamicin Sulfate: An antibiotic of the aminoglycosides, which kill bacteria through inhibiting bacterial protein biosynthesis. The actual gentamicin antibacterial spectrum includes Gram -negative aerobic bacteria and bacterial capacitors, including strains producing penicillinase and methicillin resistance.

pharmacokinetic pharmacokinetics

absorption: The drug can be absorbed through the skin to enter the bloodstream but with very small doses (1-1.5%). The skin absorbed through the skin is excreted through bile and urine.

gentamicin sutfate

Distribution: When absorbed into the blood gentamicin sutfate is attached to plasma proteins. Gentamicin sulfate diffuses mainly on extracellular fluids and easily diffuse into foreign ears.

Metabolism - Elimination: In the blood, half -life of Gentamicin Sulfate from 2 to 3 hours, can last in patients with renal impairment. Gentamicin sulfate is not metabolized and eliminated (almost unchanged) into the urine through the glomerular filtration, in a stable state, at least 70% of the dose is exported to urine for 24 hours. Gentamicin sulfate is also accumulated to some extent in the tissue of the body, especially in the kidney.

triamcinolon acetonid

absorption - distribution: When absorbed into the blood, triamcinolon acetonid is distributed into all tissues in the body (muscles, liver, skin, intestines, kidneys ...). The drug can pass the placenta and secret the milk.

Metabolism - Elimination: Triamcinolon acetonid metabolizes mainly in the liver, partly in the kidney, and the exit through the urine, half -life of plasma is 2 - 5 hours. Links to plasma albumin.

Clotrimazol

Six hours after applying the cream and 1% solution of radioactive clotriTrimazole on the skin intact and on acute inflammatory skin, clotrimazol concentration varies from 100mcg/cm3 in the horny layer to 0.5 - 1mcg/cm3 in the spinning layer and 0.1mcg/cm3 in the subcutaneous tissue layer.

Before taking Tomax Genta Detapharm skin cream for allergic skin (6g)

How to use

Use on the skin.

Dosage

Use a sufficient amount to gently apply on the skin area from 1 to many times a day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Apply clotrimazol six hours after applying 1% cream clotrimazol to the skin intact or acute inflammation, clotrimazol levels vary from 100 mcg/cm3 in the horn layer to 0.5 - 1 mcg/cm3 in mesh layer and 0.1 mcg/cm3 under the skin.

No quantitative radioactive substance (0.001 mcg/ml) in the serum within 48 hours after applying and then irritating 0.8g cream is marked into the healthy skin or the disease and then sealed for 6 hours to prevent the quantitative amount of radioactive substance into the drug serum (the lowest limit is 0.001 mcg/ml), almost no overdose when using clotrimazole.

Use more than a single dose of Gentamicin Sulfate will not cause symptoms.

Using Gentamicin Sulfate in place excessive or prolonged can aggravate the damage due to unsure microorganisms.

Handling: appropriate symptomatic treatment should be treated. Symptoms of adrenal gland growth often recover. Treatment of electrolyte balance if necessary. In the case of chronic poisoning, the triamcinolon should be slowly.

If there is an excessive hyperlike proliferation, the microorganisms are not sensitive, it is advisable to stop treating with Tomaxgenta and appropriate therapeutic replacement.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Tomax Genta, you may experience unwanted effects (ADR).

Other skin diseases: Long-term use of powerful cortico-steroids can cause steroid folliculitis caused by steroids, cyclic dermatitis, skin atrophy changes such as thin and shallow vascular stretching or skin changes such as fish scales, hemorrhage, abnormal growth and pigmentation.

Hypersensitivity: stimulating skin and rash.

Hill - pituitary - adrenal axis function: Should take the drug in a short time because this drug can inhibit the hypothalamus axis - pituitary - adrenal long, long -term adrenal or pressed tape.

Avoid widespread skin application, because the risk of absorption into the blood causes systemic corticosteroid effects: may be adrenal failure, kidney replacement.

eyes: eye diseases including glaucoma may be the result of continuous treatment with Tomaxgenta, sugar metabolism, protein catabolism, glaucom.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Tomaxgenta drugs contraindicated in the following cases:

Patients with a history of allergies to the drug. Eczema external ear has perforation.

ulcer (basalt disease).

Patients with amino-glycoside antibiotics or allergies to one of the ingredients of the drug.

Be cautious when using

When using corticoide on many wide skin areas with or without tape can lead to systemic corticosteroid absorption.

The ability to drive and operate machinery

No report.

Pregnancy

Used for pregnant women.

Breastfeeding period

Used for breastfeeding women.

Drug interaction

No information.

Storage

Closed packaging, temperature not exceeding 30 ° C.

Other drugs

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