Tomethrol 16mg anti -inflammatory, immunosuppressive and anti -cell proliferation (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Methylprednisolone

Ingredient

Composition information	Content
Methylprednisolone	16mg

Uses

indications

Tomethrol drugs are indicated in cases where glucocorticoids need:

Endocrine disorders: primary and secondary adrenal renal failure, congenital adrenal hyperplasia. PEMPHIGUS Normal (P. Vulgaris)

allergies: Seasonal or year -round allergic rhinitis, hypersensitivity reactions, serum, contact dermatitis, bronchial asthma. Pulmonary sarcoid, acute or spreading pulmonary tuberculosis when using appropriate tuberculosis chemotherapy, Inhalation pneumonia. (When using appropriate anti -tuberculosis chemotherapy), internal transplantation. The drug has anti -inflammatory effects, immunosuppressive and anti -cell proliferation. Methylprednisolon reduces production, releases inflammatory mediators (histamine, prostaglandin, leucotrien ...), thereby reducing the initial manifestations of the inflammatory process.

methylprednisolon prevents white blood cells from adhesion and immigration in damaged vessels, reducing permeability in that area, thus reducing vessel escape, swelling, edema, pain.

The immunosuppressive properties reduces response to allergic reactions III and IV. This is due to the inhibitor of the antigen complex - antibodies that cause allergic vasculitis in the skin. By inhibiting the effects of lymphocytes, target cells and macrophages, corticosteroids have reduced allergic contact dermatitis reactions. In addition, corticosteroids also prevent T -cell lymphocytes and sensitive macrophages to target cells. Anti -cell proliferating effects reduces the characteristics of psoriasis.

Methylprednisolon only has mineralocorticoid effect (very little salt metabolism), is not suitable for the adrenal insufficiency. If using methylprednisolon in this case, a combination of a mineralocorticoid.

Pharmacokinetics

absorption

Birth is approximately 80%. The drug works 1-2 hours after drinking.

Distribution

Time lasts up to 30-36 hours. The distribution volume is 0.7 - 1.5 liters/kg.

Metabolism

methylprednisolon is metabolized in the liver like metabolism of hydrocortison.

Elimination

Metabolic substances are excreted through urine. Selling waste time is approximately 3 hours and decreases for obese people.

Before taking Tomethrol 16mg anti -inflammatory, immunosuppressive and anti -cell proliferation (3 blisters x 10 tablets)

How to use

oral medication in the morning in the pace of physiological glucocorticoid secretion.

Determine the dose for individuals. The dose is needed to maintain the lower treatment effect than the dose needed to achieve the initial effect. Lowest dose must be used by reducing the dose gradually until signs or symptoms increase.

When high doses are needed for a long time, using the day after control of the disease process, there will be less unwanted effects because of the recovery time between each dose.

Dosage

In a daily -way therapy, using a single dose of methylprednisolon every 2 days.

Treatment of severe asthma attacks for inpatient patients: Priority, Methylprednisolon intravenous injection 60 - 120mg/time, every 6 hours; After getting rid of acute asthma attack, taking daily dose 32 - 48mg. Then gradually decrease the dose and may stop the drug within 10-14 days, from the start of corticosteroid treatment.

Acute asthma attacks: 32 - 48mg/day x 5 days, then additional treatment can be treated at a lower dose for 1 week. When from acute attacks, gradually reduce methylprednisolon.

Severe diseases: Initially with methylprednisolon 0.8mg/kg/day divided into small doses, then treatment maintained a single dose/day and then gradually decreases to the minimum dosage.

Rheumatoid arthritis: The starting dose of 4 - 6 mg/day. During the acute phase, taking the dose of 16 - 32mg/day, then gradually decreases quickly.

Chronic arthritis in children with life -threatening complications: Methylprednisolon is used in a 10-30mg/kg/batch attack therapy (usually 3 times).

Chronic ulcerative ulcer: Heavy exacerbations use 8 - 24mg/day.

Nephropathy syndrome: Start at a dose of 0.8 - 1.6mg/kg/day for 6 weeks, then gradually reduce the dose for 6 - 8 weeks.

Sarcoid disease: 0.8mg/kg/day to improve the disease, then use the maintenance dose 8mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

When using too high doses for a long time, it may increase adrenal gland energy and inhibit the adrenal glands. It is necessary to consider suspending or stopping the use of glucocorticoids.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Tomethrol, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Central nerve: insomnia, easily agitated.

digestion: Increase appetite, indigestion. Skin: Skin.

Endocrine and metabolism: diabetes.

Neurosomal and bone: joint pain.

Eyes: cataracts, glaucoma.

Respiratory: Nosebleeds.

Uncommon, 1/1000

Central nerve: dizziness, convulsions, psychosis, fake tumors in the brain, headache, mood change, delirium, hallucinations, refreshment.

Cardiovascular: edema, hypertension. skin: acne, skin atrophy, bruising, tissue hyperpigmentation.

Endocrine and metabolism: Cushing syndrome, pituitary inhibition, adrenal, slow growth, glucose intolerance, hypokalemia, alkaline infection, amenorrhea, sodium and water, hyperlem of blood glucose.

digestion: stomach ulcers, nausea, vomiting, bloating, esophageal ulcer, pancreatitis.

Neurosurgery and bone: muscle weakness, osteoporosis, fracture.

Body: Hypersensitivity reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Tomethrol medicine is contraindicated in the following cases:

Severe infections, except for bacterial shock and meningitis.

Too hypersensitivity to methylprednisolon.

Viral, mushroom or tuberculosis skin lesions.

is using a living virus vaccine.

Caution when using

Caution in people with osteoporosis, new people connecting blood vessels, mental disorders, stomach ulcers, duodenal ulcers, diabetes, hypertension, heart failure and growing children.

Due to the risk of unwanted, cautious effects when using whole corticosteroids for the elderly and must be used in the lowest doses, in the shortest possible time.

Acute adrenal insufficiency may occur when stopping the drug suddenly after a long time of treatment or when stressed.

When using high doses, it can affect the effects of vaccines.

The ability to drive and operate machinery

The effect of corticosteroids on the ability to drive and operate machinery has not been systematically assessed. Unwanted effects such as dizziness, dizziness, visual disorders and fatigue may occur after corticosteroid treatment. If affected by patients should not drive or operate machinery.

pregnancy

only used when necessary and must consult a doctor.

The period of breastfeeding

is only used when it is necessary and must consult a doctor.

Drug interaction

methylprednisolone is a cytochrome P450 enzyme induction and is the substrate of the P450 3A enzyme. Therefore, the drug has an impact on the metabolism of cyclosporin, erythromycin, phenobarbital, phenytoin, carbamazepin, ketoconazole, rifampicin.

phenytoin, phenobarbital, rifampin and diuretics decreased potassium can reduce the effectiveness of methylprednisolone.

methylprednisolone may cause hyperlemor of blood glucose, so higher insulin dose is needed.

Storage

In a cool dry place, temperatures below 30 ° C, avoid light.

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