Tomethrol 4mg medicine for rheumatism (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Methylprednisolone

Ingredient

Composition informationContent
Methylprednisolone4mg

Uses

Indications

Tomethrol 4 mg medicine is indicated in cases where glucocorticoids such as:

  • Endocrine disorders: primary and secondary adrenal renal failure, congenital adrenal hyperplasia. PEMPHIGUS Normal Body (P. Vulgaris). Pulmonary sarcoid, acute or spreading pulmonary tuberculosis when using appropriate tuberculosis chemotherapy, Inhalation pneumonia. (When using appropriate tuberculosis chemotherapy), organ transplantation. The drug has anti -inflammatory effects, immunosuppressive and anti -cell proliferation. Methylprednisolon reduces production, releases inflammatory mediators (histamine, prostaglandin, leucotrien ...), thereby reducing the initial manifestations of the inflammatory process.

    methylprednisolon prevents white blood cells from adhesion and immigration in damaged vessels, reducing permeability in that area, thus reducing vessel escape, swelling, edema, pain.

    The immunosuppressive properties reduces response to allergic reactions III and IV. This is due to the inhibitor of the antigen complex - antibodies that cause allergic vasculitis in the skin. By inhibiting the effects of lymphocytes, target cells and macrophages, corticosteroids have reduced allergic contact dermatitis reactions. In addition, corticosteroids also prevent T -cell lymphocytes and sensitive macrophages to target cells. Anti -cell proliferating effects reduces the characteristics of psoriasis.

    Methylprednisolon only has mineralocorticoid effect (very little salt metabolism), is not suitable for the adrenal insufficiency. If using methylprednisolon in this case, a combination of a mineralocorticoid.

    pharmacokinetic

    absorption

    Birth is approximately 80%. The drug works 1-2 hours after drinking.

    Distribution

    Time lasts up to 30-36 hours. The distribution volume is 0.7 - 1.5 liters/kg.

    Metabolism

    methylprednisolon is metabolized in the liver like metabolism of hydrocortison.

    Elimination

    Metabolic substances are excreted through urine. Selling waste time is approximately 3 hours and decreases for obese people.

    • Before taking Tomethrol 4mg medicine for rheumatism (3 blisters x 10 tablets)

    How to use

    Tomethrol drugs are used orally in the morning in the rhythm of physiological glucocorticoid secretion.

    Determine the dose for individuals. The dose is needed to maintain the lower treatment effect than the dose needed to achieve the initial effect. Lowest dose must be used by reducing the dose gradually until signs or symptoms increase.

    When high doses are needed for a long time, using the day after control of the disease process, there will be less unwanted effects because of the recovery time between each dose.

    Dosage

    In a daily -way therapy, using a single dose of methylprednisolon every 2 days.

    Treatment of severe asthma attacks for inpatient people

    Priority, Metylprednisolon intravenous injection 60 - 120mg/time, every 6 hours; After getting rid of acute asthma attack, taking daily dose 32 - 48mg. Then gradually decrease the dose and may stop the drug within 10-14 days, from the start of corticosteroid treatment.

    acute asthma attack

    32 - 48mg/day x 5 days, then additional treatment can be added at a lower dose for 1 week. When from acute attacks, gradually reduce methylprednisolon.

    Severe diseases

    Start with methylprednisolon 0.8mg/kg/day divided into small doses, then maintain a single dose/day and then gradually decrease to the minimum dosage.

    Rheumatoid arthritis: The starting dose of 4 - 6 mg/day. During the acute phase, taking the dose of 16 - 32mg/day, then gradually decreases quickly.

    Chronic arthritis in children with life -threatening complications

    Methylprednisolon is used in a dose of 10 - 30mg/kg/batch attack therapy (usually used 3 times).

    Chronic ulcerative ulcerative

    Heavy exacerbations use 8 - 24mg/day.

    Nephropathy syndrome

    Start at a dose of 0.8 - 1.6mg/kg/day for 6 weeks, then gradually reduce the dose for 6 - 8 weeks.

    Sarcoid disease

    0.8mg/kg/day to improve the disease, then use the maintenance dose 8mg/day.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when overdose?

    Symptoms

    Cushing syndrome, muscle weakness and osteoporosis, all only occur when using long -term glucocorticoids.

    When using too high doses for a long time, it may increase adrenal gland energy and inhibit the adrenal glands. It is necessary to consider suspending or stopping the use of glucocorticoids.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    Side Effects

    When using Tomethrol 4mg, you may experience unwanted effects (ADR).

    Common, ADR> 1/100

  • Central nervous system: Insomnia, ease of excitement.

    Uncommon, 1/1000

  • Central nervous system: dizziness, convulsions, psychosis, fake tumors in the brain, headache, mood change, delirium, hallucinations, refreshment. Glucose, reduced blood potassium, alkaline infection, amenorrhea, sodium and water, hyperglycemia

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    • Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Tomethrol 4mg drug is contraindicated in the following cases:

  • Severe bacterial infections, except for bacterial shock and meningitis.

    Caution when using

    Caution in people with osteoporosis, new blood vessels, mental disorders, stomach ulcers, duodenum ulcers, diabetes, hypertension, heart failure and growing children.

    Due to the risk of unwanted, cautious effects when using whole corticosteroids for the elderly and must be used in the lowest doses, in the shortest possible time.

    Acute adrenal insufficiency may occur when stopping the drug suddenly after a long time of treatment or when stressed.

    When using high doses, it can affect the effects of vaccines.

    The ability to drive and operate machinery

    The effect of corticosteroids on the ability to drive and operate machines has not been systematically assessed. Unwanted effects such as dizziness, dizziness, visual disorders and fatigue may occur after corticosteroid treatment. If affected by patients should not drive or operate machinery.

    Pregnancy

    only used when really necessary and must consult a doctor.

    Breastfeeding period

    only used when really necessary and must consult a doctor.

    Medicinal interaction

    methylprednisolone is a cytochrome P450 enzyme induction and is the substrate of P450 3A enzyme. Therefore, the drug has an impact on the metabolism of cyclosporin, erythromycin, phenobarbital, phenytoin, carbamazepin, ketoconazole, rifampicin.

    phenytoin, phenobarbital, rifampin and diuretics decreased potassium can reduce the effectiveness of methylprednisolone.

    methylprednisolone may cause hyperlemor of blood glucose, so higher insulin dose is needed.

    • Storage

    In a cool dry place, temperatures below 30 ° C, avoid light.

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