Topical on Benate Fort Ointment Merap treatment for dermatitis, psoriasis (10g)

Dosage form Tube x 10g
Specifications Clobetasol Propionate
Ingredient Eczema, psoriasis, lupus erythematosa, atopic dermatitis, contact dermatitis

Ingredient

Composition informationContent
Clobetasol Propionate0.05%

Uses

Indications

Benate Fort Ointment Merap 10 g is indicated in the following cases:

  • The drug is a formula that contains corticosteroids, which reduces inflammation and itching of skin diseases that respond to corticosteroids: persistent skin diseases, psoriasis, eczema for a long time is difficult to treat, flat lichen, lupus pink disc, and other conditions that do not respond to weaker steroids. Located corticosteroids elsewhere, Clobetasol Propionate has anti -inflammatory, anti -itching and vasoconstrictive effects. The anti -inflammatory mechanism of Clobetasol Propionat is locally used in the treatment of skin diseases that respond to corticosteroids is not sure. It is possible that the drug that causes common proteins is lipocortin has the effect of inhibiting phosphorylase A2. These proteins control the biosynthesis of strong inflammatory intermediate substances such as prostaglandin and leucotrien, due to the inhibition of Arachidonic acid release, a common precursor of prostaglandin and leucotrien. Arachidonic acid is released from film phospholipids by phospholipase A2.

    pharmacokinetics

    The level of skin absorption of Clobetasol is different between individuals and may be changed by using different carriers. Absorbing through the skin may be increased by sealed bandages, by inflammation and/or other diseases of the epidermal fence (such as psoriasis, eczema). After applying on the spot with the normal dose of clobetasol on most normal skin areas, only a small amount of the drug penetrates to the dermis, then goes into the common circulatory system. However, the whole body absorption may increase when used overdose or when the skin is inflamed, skin disease.

    The peak concentration of plasma of Clobetasol is 0.63 ng/ml occurring in a study after 8 hours of use of the second dose of 30 g (13 hours after the starting dose) of 0.05% clobetasol ointment in healthy skin with normal skin. The peak concentration of the drug is a bit higher than that has appeared after 10 hours of using the second dose of 0.05%Clobetasol cream. The peak concentration of plasma is about 2.3 or 4.6 ng/ml appearing in another study nearly 3 hours after applying a single dose of 25 g of 0.05% fat in patients with psoriasis or Eczema corresponding.

    After absorbing through the skin of Clobetasol can be metabolized in the paths of corticosteroids used in the body. However, the body metabolism of Clobetasol is not fully described or unpretently quantified. Clobetasol and its metabolites are eliminated through bile and urine in animals.

    • Before taking Topical on Benate Fort Ointment Merap treatment for dermatitis, psoriasis (10g)

    How to use

    topical skin.

    Dosage

    Apply a thin layer of clobetasol ointment to the affected skin 2 times/day, rub gently and completely.

    Do not cover. Avoid applying on open wounds and sensitive skin.

    Should stop using when symptoms are improved. If there is no sign of improvement within 2 weeks, it is necessary to diagnose.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when overdose?

    Management:

    When used for a long time and apply on a large scale (high doses), it is necessary to evaluate the adrenal function by solutions such as stimulating methods by ACTH, the method of determining cortisol in plasma and free cortisol in urine. If there is signs of adrenal insufficiency, a stop to stop the drug, reduce the number of applied times, or replace it with a lower activity glucocorticoid. When stopping the drug, the HPA axis function often recovers quickly and completely, but if there is a shortage of glucocorticoid, it must be supplemented by taking corticosteroids.

    In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

    What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not use double the prescribed dose.

    Side Effects

    When using Benate Fort Ointment Merap 10 g, you may experience unwanted effects (ADR).

    The most common side effect is burning, painful feeling like insects. Less side effects such as itching, skin atrophy, cracking, erythema, folliculitis, finger numbness and capillary dilatation. When there are signs of hypersensitivity, stop the drug immediately.

    Systemic absorption when using topical corticosteroids can inhibit the hypothalamus - pituitary - adrenal gland with the ability to deficiency of glucocorticosteroids, cushing syndrome, hyperglycemia and urinary glucose may appear in some patients.

    Notify the doctor the unwanted effects encountered when using the drug

    Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Benate Fort Ointment Merap 10 g is contraindicated in the following cases:

  • Red acne, acne, inflammation around the mouth.

    • Virus skin disease (herpes, chicken pox), fungal infection (Candida, hair fungus) or infection (impetigo).

  • Contraindicated in patients with a history of allergies to any component of the drug.

    • Caution when using

    should not be used on the face, groin or armpit.

    Do not use drugs in patients under 12 years old. The treatment should be limited to 2 consecutive weeks, and should not be used more than 50 g per week.

    If infected or fungal infection at the same time, clobetasol treatment, combined with appropriate antibiotics or antifungal drugs, if infected, fungal infections are not controlled immediately, stop clobetasol until they have been controlled by bacterial infections, fungal infections.

    The ability to drive and operate machinery

    No report.

    Pregnancy

    There is no adequate and controlled study when using Clobetasol Propionate in pregnant women. Benate Fort Ointment should be avoided for pregnant women.

    Breastfeeding period

    Be cautious when using the drug in breastfeeding women.

    Drug interaction

    No report.

    Storage

    Where dry, under 30 ° C, avoid direct light.

    Expiry date: 36 months from the date of manufacture. Do not use overdue drugs stated on the packaging.

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