TopRalsin Benovas treats symptoms of dry cough, allergies and irritation (24 tablets)

Paracetamol (acetaminophen or N - acetyl - P - Aminophenol) is a metabolic substance with the activity of phenacetin, an effective analgesic - antipyretic. Paracetamol reduces body temperature in fever, but rarely reduces body temperature in normal people. The drug acts on the hypothalamus, causing cooling off, increasing heat due to vasodilation and increased peripheral blood flow. Paracetamol, with treatment, less impact on the cardiovascular and respiratory system, does not change acid -base balance, does not cause irritation, scratches or stomach bleeding like when using salicylate, because paracetamol does not work on the body cycloxygenase, only affect cycloxygenase/prostaglandin of the central nervous system. Paracetamol does not work on platelets or bleeding time. When an overdose of paracetamol, a metabolic substance is N - Acetyl - Benzoquinonimin that is toxic to the liver.

Guaifenesin has a sputum effect by irritating the gastric mucosa, then stimulates increased secretion in the
respiration, increasing the vol As a result, the drug increases the effectiveness of cough reflexes and makes it easier to expel phlegm. This mechanism is different from the mechanism of anti -cough drugs, the drug does not lose cough. The drug is indicated to treat symptoms of cough with thick sputum is difficult to cough due to colds, mild respiratory inflammation.

Sodium benzoat stimulates the excretion in the bronchus.

Dynamic pharmacokinetics

paracetamol quickly absorbed and completely through the digestive tract. The distribution is evenly distributed in most body tissues, 25% of the blood paracetamol combined with plasma proteins. Eliminate 90 - 100%of the drug through the first day of urine, mainly after the liver combination with glucuronic acid (about 60%), sulfuric acid (about 35%), or cysteine ​​(about 39%); Also detected a small amount of hydroxyl metabolites - chemical and reducing acetyl.

Paracetamol is n -hydroxylation by cytochrom P450 to create N - Acetyl - Benzoquinonimin, an intermediate reaction. This metabolic substance normally reacts with sulfhydryl groups in glutathion and is dimidated. If Paracetamol is taken high doses, this metabolite forms a sufficient amount to exhaust the glutathion of the liver. Its reaction to the increasing sulfhydryl of liver protein leads to liver necrosis.

GuaiFenesin absorbs well through the gastrointestinal tract. In the blood, 60% of the drug is hydrolyzed for 7 hours. The metabolites are no longer active and excreted through the kidneys. Half of the lifetime of Guaifenesin about 1 hour.

Oxomemazin has no research on pharmacokinetics data.

Sodium benzoat has no research on pharmacokinetics data.

What to do when overdose?

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Skin rash and other allergic reactions occur. Usually erythema or urticaria, but sometimes worse and may be accompanied by fever due to drugs and mucosal lesions. Patients with susceptibility to rare salicylate sensitive to paracetamol and related drugs.

In a few individual cases, paracetamol has caused neutropenia, thrombocytopenia and hypoglycemia.

Uncommon, 1/1000

Other unwanted or unexpected effects such as:

The unwanted effects are usually light, all self. If vomiting or abdominal pain should stop the drug. Avoid prolonged medication. Very cautious when taking children for children.

Notify the doctor with unwanted effects when taking the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Doctors need to warn patients on signs of serious skin reactions such as Stevens - Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

Paracetamol is relatively non -toxic to treatment. Sometimes there are skin reactions including itchy and urticaria, other sensitive reactions including laryngeal edema, angioedema, and anaphylactic reactions that may rarely occur. Platelets, leukopenia, and all bloody hematuria have occurred with the use of p - aminophenol derivatives, especially when used for large doses. Neutral leukopenia and thrombocytopenic hemorrhage occur when using paracetamol. Rarely loss of granulocytes in patients using paracetamol.

Must use paracetamol carefully in patients with anemia before, because purple blue may not show clearly, although there are dangerous high concentrations of methemoglobin in the blood.

Drinking plenty of alcohol can cause toxicity to the liver of paracetamol; Should avoid or limit drinking. Do not use drugs in the case of prolonged or chronic cough like smoking patients, asthma, chronic bronchitis, lung gas or cough with too much phlegm.

Patients should be fully rehydrated while using the drug. Do not arbitrarily take the medicine for more than 7 days without consulting the doctor. The drug containing glutinous dowovers can be used for people with intestinal diseases, but patients with allergies to wheat should not use this drug.

The ability to drive and operate machinery

The drug can cause dizziness and fall asleep. Need to avoid being used for people who are driving or operating machinery.

Pregnancy

There is no drug safety report when used for pregnant women. Should not be used for pregnant women.

The period of breastfeeding

has not determined the safety of the drug for mothers during breastfeeding. Should not be used while breastfeeding.

Drug interactions

Do not use this drug with preparations containing dextromethorphan for patients who are taking MAO inhibitors. Be careful when using this drug with preparations containing phenylpropanolamine for patients with hypertension, heart disease, diabetes or peripheral vascular disease, prostate hypertrophy and glaucoma.

Out of alcohol too much and long may increase the risk of liver toxicity. Anti -convulsions (Phenytoin, Barbiturat, Carbamazepin) cause enzyme induction in the liver microsom, which can increase liver toxicity due to increased drug conversion into toxic substances to the liver. In addition, simultaneously used with isoniazid can also lead to an increased risk of liver toxicity.