Topralsin Pharimexco drugs treat symptoms of dry cough (24 tablets)

Dosage form Box of 24 tablets
Specifications Paracetamol, Guapiphenesin, Sodium Benzoate, Oxomemazine

Ingredient

Thành phần cho 1 viên

Composition information	Content
Paracetamol	33.3mg
Guiphenesin	33.3mg
Sodium benzoate	33.3mg
Oxomemazine	1.65mg

Uses

Indications

Treatment of dry cough symptoms, especially coughing at night (cough due to allergies and irritation).

Pharmacological

oxomemazin:

is the derivative of phenothiazine dimethyllaminpropyl group, which has antihistamine and sedative effects. Like H1 antihistamines, oxomemazin disputes with histamine in the positions of the H1 receptor on the acting cells, but does not prevent the release of histamine, so the drug only prevents the reactions created by histamine including: urticaria, rashes.

oxomemazine is completely antagonistic with histamine at the trachea smooth muscle, digesting causes these muscles and partial antagonists on the heart causing reduced capillary permeability. Oxomemazin does not inhibit gastric secretion. Oxomemazin causes hypotension standing in patients sensitive to drugs.

In the treatment dose, the drug can be stimulated or incharged in the central nervous system. The stimulating effect on the central nervous system manifests itself with restlessness, temper, difficulty sleeping. The central neurological inhibitor is manifested by reducing agility, slow reaction time, drowsiness.

GuaiFenesin:

Antiseptic respiratory tract.

paracetamol:

is an analgesic, antipyretic. Reduce body temperature in fever, rarely reduce body temperature in normal people. The drug acts on the hypothalamus, causing cooling off, increasing heat due to vasodilation and increased peripheral blood flow. When an overdose of paracetamol, a metabolic substance is N-acetyl-benzoquinonimin that is toxic to the liver.

sodium benzoate:

Stimulates the excretion in the bronchus.

Dynamic pharmacokinetics

paracetamol absorbs quickly and completely through the digestive tract. The distribution is evenly distributed in most body tissues, 25% of the blood paracetamol combined with plasma proteins. Eliminate 90 - 100%drugs through the first day urine, mainly after the liver combination with glucuronic acid (about 60%), sulfuric acid (about 35%), or cysteine (about 3%) also detect a small amount of hydroxylation and reducing substances.

Before taking Topralsin Pharimexco drugs treat symptoms of dry cough (24 tablets)

How to use

oral medication.

Dosage

should be treated with short -term drugs, for a few days.

Adults: Take 2 - 6 capsules/ day, divided into 2-3 times.

Children: Use according to the guidance of the drug.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms of overdose:

In children: excitement, hallucinations, dance, convulsions. The pupils are fixed and dilated, the skin is flushed and high fever. Finally, there may be severe coma with cardiovascular collapse, death may occur in 2 - 98 hours.

In adults: depression and coma can occur before the agitation and seizures.

How to handle:

Symptomatic treatment, respiratory aid, artificial respiration, anti -convulsed drugs.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

oxomemazin:

Common, ADR> 1/100

Neurological: Drowsy, dizziness.

Respiratory: Increasing bronchial secretions.

digestive: dry mouth, constipation, urinary retention.

Other: Red Red.

Rare, 10,000

digestive: anorexia, nausea, vomiting, diarrhea.

Very rare, ADR

Neurological: late dysplasia due to prolonged use of antihistamine drugs of phenothiazin groups, stimulating phenomena in children and breastfed children.

immunity: leukopenia and granulocytes.

GuaiFenesin:

Rare, 1/10,000

Cardiovascular: tachycardia, arrhythmia (including atrial fibrillation, ventricular tachycardia and extra -collection) in sensitive patients.

paracetamol:

Uncommon, 1/1000

Body: Ban.

digestive: nausea, vomiting.

Hematopsiia: Hematopoiia (neutral hematoma, all bloody hemoglobin, hypoglycemia), Anemia.

kidney - urinary: kidney disease, kidney toxicity when abusing for a long time.

Rare, 10,000

Body: Hypersensitivity reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Contraindicated

Patients with respiratory failure, liver failure.

Caution when using

Do not drink alcohol during the period of treatment.

The ability to drive and operate machinery

The drug can cause dizziness and fall asleep. Need to avoid being used for people who are driving or operating machines.

Pregnancy

There is no drug safety report when used for pregnant women. Should not be used for pregnant women.

The period of breastfeeding

has not determined the safety of the drug for mothers during breastfeeding. Should not be used while breastfeeding

Drug interaction

Do not take medicine with zidovudin, levodopa, guanethidin and substances of the same them.

Be cautious when taking drugs with salt, oxyd, and hydroxyd of Mg, AI, CA.

Some other combinations should also be noted: antihypertensive drugs, atropine and substances that have atropinic effect, nervous systems that cause nervous system.

Storage

Leave the medicine in a cool dry place, temperatures below 30 ° C, avoiding light.

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