Toraxim phase powder 400mg/50ml Deltapharm Treatment of infection (50ml)

Dosage form Box X 50ml
Specifications Cefpodoxime

Ingredient

Thành phần cho 50ml

Composition information	Content
Cefpodoxime	400mg

Uses

indications

Toraxim drugs are indicated in the following cases:

Upper respiratory infections: Acute otitis media, acute sinusitis, sore throat and tonsillitis. Due to poisoning, boils, follicles, poisoning and skin ulcers. Low, Cefpodoxim has a high sustainability of the attack of beta - lactamase, created by Gram -negative and gram -positive bacteria.

Cefpodoxim is a broad spectrum antibiotic against many common pathogenic bacteria, including beta -lactamase secretion strains. Cefpodoxim stabilizes well in Beta - Lactamase bacteria environment and thus works for many strains of resistance to ampicillin and amoxycillin in principle, cefpodoxim has energy for gram -positive bridge such as pneumococcal (streptococcus pneumoniae), streptocococcus (streptococcus) Staphylococcus aureus, S. Epidermidis whether or not produces beta - lactamase. However, the drug has no anti -staphylococcus staphylococcus aureus - penicillin due to changes in penicillin -mounted proteins (the resistance type of methicillin methicillin staphylococcus). This MRSA antibiotic resistance is growing in Vietnam.

Cefpodoxim also works for Gram -negative bacteria, Gram -positive and gram -negative bacilli. The drug has anti -anti -gram -negative bacteria that are important. Coli, Klebsiella, Proteus Mirabilis and Citrobacter.

However, in Vietnam, these bacteria are also resistant to cephalosporin 3rd generation. This issue should be noted because it is a risk of failure in treatment.

In contrast to other oral cephalosporins, sustainable cefpodoxim for beta - lactamase due to Haemophilus Influenzae, Moraxella Catatrhalis and Neisseria born.

However, this comment has not been monitored with Vietnam system and the activity of Cefpodoxim is higher than the extent compared to the effort of other oral cephalosporins.

Cefpodoxim has little effect on Proteus vulgaris, Entratia, Serratia Marcesens and Clostridium Perfringens. These bacteria are sometimes completely resistant.

Staphylococcus a staphylococcus of methicilin, Staphylococcus Saprophyticus, Enterococcus, Pseudomonas Aeruginosa, Pseudomonas spp All cephalosporins.

Cefpodoxim on the market is the form of oral cefpodoxim Proxetil (ester of Cefpodoxim). Cefpodoxim Proxetil has little antibacterial effect when not hydrolyzed into cefpodoxim in the body. Cefpodoxim Proxetil is absorbed through the gastrointestinal tract and is metabolized by non -specific esterases, maybe in the intestinal wall, the metabolite of Cefpodoxim is effective.

Dynamic pharmacokinetics

bioavailability of cefpodoxim is about 50%. This biological use increases when using Cefpodoxim with food. The half -life of Cefpodoxim is 2.1 - 2.8 hours for patients with normal kidney function. Half of the serum increases to 3.5 - 9.8 hours in people with kidney disabled. After taking a dose of Cefpodoxim, in healthy adults has a normal renal function, plasma peak concentration is reached within 2-3 hours and has an average value of 1.4 micrograms/ml, 2.3 micrograms/ml, and 3.9 micrograms/ml for doses of 100 mg, 200 mg, and 400 mg.

about 40% Cefpodoxim binds to plasma proteins. The drug is eliminated in the form of non -change through the filter of the glomerular and excretion of the renal tubules. About 29 - 38% of the dose is eliminated within 12 hours in adults with normal kidney function. There is no biological change in the kidneys and liver. The drug is eliminated to a certain extent when the hemorrhage.

Before taking Toraxim phase powder 400mg/50ml Deltapharm Treatment of infection (50ml)

How to use

Toraxim orally.

Dosage

Common dose

Adults and children over 12 years old

Take 100 - 400 mg 12 hours/time.

Children from 2 months old to 12 years old

Take 10 mg/kg/day, divided into 2 times, 12 hours apart (maximum dose 400 mg/day).

recommended dose for some specific diseases

Adults and children over 12 years old

The acute drama of chronic bronchitis or mild pneumonia to the community: The common dose of Cefpodoxim is 200 mg/time, every 12 hours, for 10 or 14 days, corresponding to the above diseases.

Sore throat and/or tonsillitis due to streptococcus pyogenes infection: Cefpodoxim dose is 100 mg, every 12 hours, for 5 to 10 days.

Skin infections and mild and medium -complicated skin organizations: The common dose is 400 mg/time, every 12 hours, for 7 to 14 days.

Mild to medium -sized urinary infections have no complications: 100 mg/time, every 12 hours, used for 7 days.

Inhuman illness in men and women: take a single dose of 200 mg or 400 mg Cefpodoxim, followed by oral doxycyclin treatment to prevent chlamydia infection.

Children from 2 months old to 12 years old

Acute otitis media: 5 mg/kg (to 200 mg) 12 hours apart, for 5 days. Sore throat and tonsils by S. Pyogenes (Beta hemolytic bacterial bacteria): 5 mg/kg (to 100mg) 12 hours/time, for 5 to 10 days.

Acute sinusitis (mild to medium sinusitis): 5 mg/kg (to 200mg)/12 hours, for 10 days.

Invalid illness (8 -year -old children, weighing over 45 kg): A single dose of 400 mg, in combination with an antibiotic effect on chlamydia infection.

Pneumonia in the community, exacerbations due to chronic bronchitis: 200 mg/time, in 14 days and 10 days, respectively.

Skin and skin structure: 400 mg every 12 hours, for 7 to 14 days.

Uncomplicated urinary tract infections: 100 mg/time, for 7 days.

Dose for people with kidney failure

Must reduce the dose depending on the degree of renal failure. For diseases with creatinine clearance less than 30 ml/min and no blood separation, oral dosage, every 24 hours.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

Nausea, vomiting, diarrhea, abdominal pain, headache, allergic reactions such as rash, urticaria, itching.

Treatment:

In case of serious toxic reactions due to overdose, dialysis or peritoneal can assist in removing Cefpodoxime from the body, especially if the kidney function is damaged.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Toraxim you can experience unwanted effects (ADR).

Digestive: Nausea, vomiting, diarrhea, abdominal pain.

Allergic reactions: Diverse erythema, urticaria, itching, reaction like serum with rash, fever, joint pain and anaphylactic reaction. liver: Disorders of liver enzyme, hepatitis and temporary jaundice. Blood: Eosin hypernagus, blood disorders.

kidney: interstitial nephritis has a recovery.

Central nervous system: headache, increased activity, agitation, difficulty sleeping, confusion, increased tone, dizziness, and dizziness.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Toraxim drugs contraindicated in the following cases:

Patients who are allergic to cephalosporin or antibiotics of cephalosporin.

Patients with porphyrin metabolic disorders.

Be cautious when used

to reduce the growth of anti -drug bacteria and maintain the effectiveness of Cefpodoxime and other antibacterial drugs, before appointment of drugs, it is necessary to make antibiotics to identify sensitive bacteria.

Antibacterial treatment, including Cefpodoxime, may cause excessive growth of Clostridium bacteria that cause diarrhea and colitis (CDAD; also known as diarrhea related to antibiotics and colitis or fake colitis).

Hypersensitivity reactions: Hypersensitive reactions can be seen as urticaria, itching, rash, fever and chills, eosinophilia, arthritis or inflammation, edema, erythema, genitals and anus, angiography, shock, hypotension, vasodilation, Stevens - Johnson syndrome, diverse roses, toxic, epidermal necrolysis cephalosporins.

If the hypersensory reaction occurs, it is necessary to stop using cefpodoxim and treat appropriate drugs such as epinephrine, corticosteroids, and necessary for oxygen patients.

Avoid using patients who have had hypersensitivity reactions to penicillin and cephamycins antibiotics, because of the diagonal hypersensitivity reaction between antibiotics.

In cases of renal function impairment, the total daily dose of cefpodoxim should be reduced depending on the degree of creatinin clearance.

Cefpodoxim should be used carefully for patients who are using simultaneously drugs that are likely to diuretic.

The ability to drive and operate machinery

Do not use the drug when driving or operating machinery and equipment, because the drug can cause stress, dizziness, dizziness.

Pregnancy

There are no complete and strictly controlled studies on the use of Cefpodoxim Proxetil for pregnant women, but no evidence is found about teratogenic as well as causing deformities in animal tests. However, the drug is only used for pregnant women when really necessary.

The period of breastfeeding

cefpodoxim is excreted in breast milk, so it is necessary to decide to stop breastfeeding or stop using the drug.

Interactive drug

Simultaneous use of antacids or H2 inhibitors reduces absorption and cefpodoxim levels in plasma.

Probenecid inhibits the excretion of cefpodoxim.

Need to closely monitor kidney function when Cefpodoxim is used simultaneously with compounds that are likely to cause kidney poisoning.

Storage

Store drugs in a cool dry place, below 30 ° C, avoid light.

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