Toussolène medicine 5mg khahopharma treatment for urticaria and itching (10 blisters x 25 tablets)

Alimemazin competes with histamines at H1 histamine receptors, thus having H1 antihydration effect. The drug is against the majority of pharmacological effects of histamine, including urticaria, itching.

Alimemazine has a sedative effect due to the inhibition of nistamine n - methyltransferase and due to the blocking of the central histamine secretion simultaneously with the effect on other receptors, especially the serotonergic receptor.

Dynamic pharmacokinetics

Alimemazin is quickly absorbed through the gastrointestinal tract. After taking 15-20 minutes, the drug works and lasts 6 - 8 hours. The maximum plasma alimemazin concentration after 4.5 hours in the form of tablets. The sale time is 5 - 8 hours, linked to plasma proteins is 20 - 30%. Alimemazin converts mainly through the liver into N - Desalkyl metabolites with unknown activity and elimination through the kidneys in the form of sulfoxyd metabolites (70 - 80%, after 48 hours).

Do not exceed the recommended dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Sleep or consciousness disorders, lower blood pressure, increase heart rate, transform electrocardiogram, ventricular arrhythmia and lower body heat. Severe surgeon reactions may occur.

Management:

If detected early (before 6 hours, after overdose) is best to wash the stomach. The method of causing is not used. Can use activated carbon. There is no specific antidote. Need supportive treatment.

Muscle gankers such as dopamine can be used in case of not resolving heart - vessels by infusion. Often do not use peripheral vasoconstrictions, avoid using epinephrin.

ventricular or erratic tachycardia responds when the body temperature returns to normal and circulating or metabolic disorders are adjusted. If continuing or life -threatening, anti -arrhythmia can be used. Avoid using lignoCaine or anti -arrhythmic drugs with prolonged effects.

When severely inhibited TKTW, respiratory assistance is needed. Heavy muscle -hypertonic reactions often respond to processes (5 - 10 mg) or orphenadrin (20 - 40 mg) intramuscular or intravenously. Convulsions need to be treated with intravenous diazepam intravenously.

Malignant syndrome caused by sedatives should be treated with cooling for patients and can use sodium dantrolen.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Notify the physician the unwanted effects when using the drug.

Be cautious when using

Precautions when used for the elderly, especially when the weather is very hot or very cold (causing risk of increasing or cooling). Elderly people are prone to decreased blood pressure, fainting, confusion and foreign symptoms.

Need to notify the patient to know the phenomenon of drowsiness in the early days of treatment and recommend that they should not control the cars and machines during the medication days.

Alimemazin can affect skin tests with allergens. Avoid alcohol or other central neurological inhibitors.

Be cautious for patients with cardiovascular disease, epilepsy, asthma, stomach ulcers or pyloric inflammation- duodenum; Family history has sudden death syndrome in infants.

Be cautious when used for children with a history of sleep apnea.

Warning for lactose excipients: Patients with rare genetic disorders in galactose tolerance, Lactase Lapping deficiency or glucose - galactose absorption disorders should not be used.

Erythrosin color excipients in the drug can cause allergic reactions, so it must be cautious when taking the drug.

The effect of the drug on the ability to drive and operate machinery

Drugs that cause drowsiness should pay attention when used for drivers and people operating machinery.

Use drugs for women during pregnancy and lactation

Pregnancy

Symptoms that cause jaundice and pagoda symptoms in young children have used this drug during pregnancy. Phải tránh dùng alimemazin cho người mang thai, trừ khi thầy thuốc xét thấy cần thiết.

Breastfeeding period

Alimemazin can excrete in breast milk, so do not use medication for nursing mothers or have to stop breastfeeding during medication.

Medicinal interaction

The sedative effect of phenothiazin can be stronger due to alcohol, anxiety reducing pills, sleeping pills, painkillers of opioid group, barbiturate and other sedatives. Muscarinic resistance and sedative effects of phenothiazin can increase with three -round antidepressants & imao (like moclobemid). Respiratory decline may occur.

The hypotension effect of most anti -hypertension drugs, especially the alpha - adrenergic receptor blockers increased when used in combination with phenothiazine derivatives. The use of Muscarinic resistant will increase the risk of side effects of Muscarinic resistant when used with histamine resistance.

The mild cholinergic resistance of phenothiazine increases when combined with other anti -cholinergic drugs, leading to constipation, heat, etc.

Phenothiazine antagonists with therapeutic effects of amphetamine, levodopa, clonidin, guanethidin, adrenalin.

anti -cholinergic drugs can reduce the anti -psychotic effect of phenothiazin.

Some drugs that prevent the absorption of phenothiazin: antacids, Parkinson's medicine, lithium. Increasing or decreasing plasma concentrations of some drugs, for example: propranolol and phenobarbital have been observed but does not have clinical significance.

High doses of phenothiazine reduces response to hypoglycemic agents, so the dosage must increase.

Adrenalin is not used for patients with overdose of phenothiazin.

As well as other sedative phenothiazin derivatives, should be cautious when used simultaneously with drugs that extend the qth or the drug that causes electrolyte imbalance.