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Transamin Injection daiichi injection treatment for lymphatic disease, non -regenerated anemia (1 blister x 10 tubes x 5ml)

Dosage form Box of 1 blister x 10 tubes x 5ml
Specifications Acid Tranexamic

Ingredient

Thành phần cho 5ml

Composition information	Content
Acid Tranexamic	250mg

Uses

indications

Transamin Injection 250 mg is indicated in the following cases:

Indications for treatment of bleeding trends is considered to be related to fibrin hypertrophy (lymphatic disease, non -regenerated anemia, hemorrhage, abnormal bleeding during and after surgery). ). It is also related to the process of onset, progress and treatment of many types of bleeding and allergies, including the reactions in the body caused by plasmin.

Transamin inhibits the effects of plasmin and has anti -bleeding, anti -allergy and anti -inflammatory effects.

Plasmin resistance effect

Tranexamic Acid is strongly attached to the Lysine link position (LBS), a affinity position with fibrin of plasmin and plasminogen, and inhibits the link of plasmin and plasminogen on fibrin. Therefore, the decomposition by plasmin is strongly inhibited. With the presence of plasmin resistance such as α2-macroglobulin in plasma, the fibrin-resistant effect of tranexamic acid is also enhanced.

Hemostatic effect

excessive plasmin causes platelet capacitors, the decomposition of blood clotting agents ..., but even a slight increase also makes the specific degeneration of fibrin occur first. Therefore, in cases of normal bleeding, the presence of tranexamic acid produces hemostasis by eliminating that fibrin decomposition.

Dynamic pharmacokinetics

Blood concentrations, with a dose of 500 mg of tranexamic acid given by intramuscularly or 1000 mg for intravenously for healthy adults, respectively 21.2 Ug/ml (30 minutes after drug use) and 60 Ug/ml (15 minutes after medication). Biological destruction time is 2.0 hours and 1.9 hours respectively.

When 1000 mg of tranexamic acid through an intravenous intravenously for healthy adults, the level of urinary exhaust is about 80% for 24 hours after giving the drug. When giving 500 mg through intramuscularly, the deduction level is 55% after 4 hours and 75% after 24 hours.

Before taking Transamin Injection daiichi injection treatment for lymphatic disease, non -regenerated anemia (1 blister x 10 tubes x 5ml)

How to use

Medicines used in intramuscular or intravenously.

Dosage

Lymphatic disease

For ordinary adults, use 250 - 500 mg of tranexamic acid daily intramuscularly or intravenously or divided into two times.

Non -regenerated anemia

For ordinary adults, use 250 - 500 mg of tranexamic acid daily intramuscularly or intravenously or divided into two times.

Bleva board

For ordinary adults, use 250 - 500 mg of tranexamic acid daily intramuscularly or intravenously or divided into two times.

Abnormal bleeding is considered to be related to fibrin in place

can be used 500 - 1000 mg intravenously or 500 - 2500 mg drip injection at each time as required during or after surgery.

Lung bleeding

For ordinary adults, use 250 - 500 mg of tranexamic acid daily intramuscularly or intravenously or divided into two times.

Bleeding in the nose

For ordinary adults, use 250 - 500 mg of tranexamic acid daily intramuscularly or intravenously or divided into two times.

Bleeding in the genitals

For ordinary adults, use 250 - 500 mg of tranexamic acid daily intramuscularly or intravenously or divided into two times.

Bleeding in the kidneys

For ordinary adults, use 250 - 500 mg of tranexamic acid daily intramuscularly or intravenously or divided into two times.

Abnormal bleeding during or after prostate surgery

can be used 500 - 1000 mg intravenously or 500 - 2500 mg drip injection at each time as required during or after surgery.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? The overdose symptoms may be: nausea, vomiting, symptoms and/or hypotension.

There is no special measure to treat Tranexamic acid poisoning. If the poisoning is overdosed, causing vomiting, gastric lavage and active carbon. In both cases of oral and infusion, it is advisable to maintain additional fluids to promote the excretion of the kidneys and use symptomatic treatments and support treatment.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Transamin Injection 250 mg , you may experience unwanted effects (ADR).

Uncommon, 1/1000

Digestive: Nausea, vomiting.

Rare, ADR

allergies : itching, rash.

Eye: Mink color blind (intravenous).

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Transamin Injection 250 mg contraindicated in the following cases:

Patients are using thrombin.

Patients with a history of hypersensitivity to any component of the drug.

Caution when using

must be cautious when taking this medication for the following patients:

Patients with thrombosis (brain thrombosis, myocardial infarction , thrombosis ...) and in patients with thrombosis may occur (it may stabilize thrombosis).

Patients with medication blood clotting disease (simultaneously used with heparin ...) (it can stabilize thrombosis).

Patients with surgery, immobile patients and patients are undergoing bleeding (venous thrombosis may occur and transamin may stabilize thrombosis.

Dosage in patients Severe renal failure .

Patients with a history of hypersensitivity to the drug.

The ability to drive and operate machinery

very rare cases of drowsiness occurs. However, for safety, be careful when driving and operating machinery.

Pregnancy

Clinical experience from the treatment of tranexamic acid in pregnant women is very limited, so far experimental or clinical data shows no risk when taking the drug. The material that uses tranexamic acid for pregnant women has very little, so only use drugs during pregnancy when it is strictly indicated and when it is not possible to use other treatments.

Lactation period

transamin secreted into breast milk, but the risk of side effects on children is not sure that can occur at normal doses. So the usual dosage can be used in women who breastfeed when necessary.

Drug interaction

Contraindicated using transamin with thrombin because it can cause thrombotic trends.

Be cautious when used in combination with transamin with the following drugs: Blood coagulation, batroxobin, clotting factors (for example, Eptacog-Alfa).

Storage

Store in a dry place, the temperature does not exceed 30 ° C, avoiding light.

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Disclaimer

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