Transamin tab.500mg daiichi treatment for lymphatic disease, non -regenerated anemia (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Tranexamic acid

Ingredient

Composition information	Content
Tranexamic acid	500mg

Uses

Indications

Transamin Tablets 500mg in the following cases:

Treatment of bleeding trends is considered to be related to fibrin hypertrophy: lymphatic disease, non -regenerated anemia, hemorrhage, etc., and abnormal bleeding during and after surgery. Treatment of menstrual bleeding.

Code ATC: B02AA02

Plasmin resistance effect

Tranexamic Acid is strongly attached to the Lysine link position (LBS), a affinity position with fibrin of plasmin and plasminogen, and inhibits the link of plasmin and plasminogen on fibrin. Therefore, the decomposition by plasmin is strongly inhibited. With the presence of plasmin resistance such as α2-macroglobulin, in plasma, the fibrin resistance effect of Tranexamic acid is also enhanced.

Hemostatic effect

excessive plasmin increases in the inhibition of platelet capacitors, the decomposition of blood clotting agents, etc., but even a slight increase also makes the degeneration specific to Fibrin occurred first. Therefore, in cases of normal bleeding, the presence of tranexamic acid produces hemostasis by eliminating that fibrin decomposition.

pharmacokinetics

After oral use, the concentration obtained is 1.13% and 39% of the dose after 3 and 24 hours, respectively. After tranexamic acid intravenous injection, the average half -life in the plasma of the drug is 2 hours. Tranexamic acid can be given to the placenta, and the concentration of breastfeeding women can reach a percentage of peak concentration in serum. Tranexamic acid can pass the bloodstream barrier.

blood concentration

blood concentration, at a dose of 250mg and 500mg of tranexamic acid, orally orally used in healthy adults, reaching the highest concentration of 3.9µg/ml (for a dose of 250mg) and 6.0µg/ml (for a dose of 500mg) 2 - 3 hours after drinking. Biological destruction time is 3.1 hours and 3.3 hours respectively.

Elimination

When using 500mg of tranexamic acid orally for healthy adults, the rate of excretion through urine is 30 - 52% in 24 hours after taking the drug.

Before taking Transamin tab.500mg daiichi treatment for lymphatic disease, non -regenerated anemia (10 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

For ordinary adults for drinking 750mg to 2000mg Tranexamic acid daily divided into three or four times.

The dose may be adjusted depending on the age and symptoms of the patient: 2 - 4 tablets/day, divided into three or four times.

In menstrual indication, the recommended dose for adults is 1g (2 tablets) 3 times a day of the day starting from the first day of the period of many days out.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? The overdose symptoms may be: nausea, vomiting, symptoms and/or hypotension. There is no special measure to treat tranexamic acid poisoning.

If the poisoning is overdose, causing vomiting, gastric lavage and active carbon. In both cases of oral and infusion, it is advisable to maintain additional fluids to promote the excretion of the kidneys and use symptomatic treatments and support treatment.

What to do when forgetting a dose? Just take the next dose plan.

Side Effects

Common, ADR> 1/100

Sensitive: itching, rash, ...

stomach - intestines: anorexia, nausea, vomiting, diarrhea, heartburn. Other: Drowsiness.

Instructions on how to handle ADR:

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Contraindicated

Transamin Tablets 500mg contraindications in the following cases:

Patients with thrombosis.

Patients with a history of hypersensitivity to any component of the drug.

Be cautious when using

tranexamic acid can stabilize thrombosis in patients with thrombosis (brain thrombosis, myocardial infarction, thrombosis, etc.) and in patients may have thrombosis.

Tranexamic acid can stabilize thrombosis in patients with blood clotting disease (simultaneously used with heparin, etc.).

In postoperative patients, the patient lies motionless and the patient is being bandaged. Venous thrombosis can occur, and transamine may stabilize thrombosis. There is a report on pulmonary embolism related to changing the lying position or removing the bleeding.

Patients with renal impairment can cause increased concentration of tranexamic acid in the blood.

Acid Tranexamic is used cautiously in patients with a history of hypersensitivity.

Tranexamic Acid should be used cautiously when used with estrogen because it can cause more thrombosis.

In elderly patients, due to the reduced physiological function, there should be measures to reduce the dose with careful supervision.

The ability to drive and operate machinery

Very rare cases of drowsiness occurs, however, for safety, be careful when driving and operating machinery.

Pregnancy

There is no safety data.

Breastfeeding period

There is no safety data.

Tranexamic acid secretes breast milk with a concentration of 1/100 corresponding concentration in serum.

Drug interaction

Contraindicated in combination with drugs

Thrombin: Combined treatment can increase the trend leading to thrombosis due to the blood clots of the drug.

Be cautious when used in combination with the drugs:

Hemocoagulase: Treatment in combination with high doses can cause thrombosis trends.

Batroxobin: Combined treatment can cause thrombosis.

Freezing factors (for example, Eptacog-Alfa): Blood coagulation can be activated in the location of increased fibrin dulls on the spot, such as oral cavity.

Storage

Store in a dry place, less than 30 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.