Travatan Novartis eye drops dilate the glaucoma (2.5ml)

Dosage form Box X 2.5ml
Specifications Travoprost

Ingredient

Composition information	Content
Travoprost	0.04mg/ml

Uses

Indications

Travatan eye solution is indicated that reduces glaucoma in patients with glaucoma or patients with Glaucoma disease open angle .

Pharmacokological

Travoprost, a substance similar to Prostaglandin F2α, is a selective and highly affinity agent with Prostaglandin FP receptor, reducing internal pressure by increasing hydrogen epidemic escape through Portuguese and Chung Mac. Reducing internal pressure in humans starts for about 2 hours after the eye and reaches the maximum effect within 12 hours. Significant reduction in internal pressure can be maintained for more than 24 hours after single dose.

In the main treatment, Travatan used once a day, reducing the internal pressure of 7 - 9 mmHg. The reduction of internal pressure reaches a daily stable state after 2 weeks from the beginning of treatment and is maintained over 6 to 12 months of treatment.

In addition, Travoprost also shows the effect of increasing blood flow at the end of the optic nerve, reducing the stability of the tear film and reducing tears.

Travoprost does not affect the rhythm/respiratory volume or systolic blood pressure when exercising and recovery. Similar drugs Prostaglandin F2α can cause the development stage in the hair follicle and stimulate the process of dark pigmentation in the skin.

pharmacokinetic

absorption

Travoprost is an isopropyl ester. The drug is absorbed through the cornea, where the ester is hydrolyzed into a free -active acid. In Vivo, the maximum concentration of free acid of Travoprost in the aquatic fluid is about 20 ng/ml, achieved within 1-2 hours after the eye. The free acid concentration of Travoprost in the aquarium decreases with a half -life time. After small eyes, the free acid of Travoprost is also found in plasma with low concentrations.

Distribution

After small eyes in humans, the systemic exposure of free acid has low activity, the peak concentration in plasma is about

Metabolism

Metabolic is the main clearance for both Travoprost and free acid. The body metabolism is similar to the metabolic path of prostaglandin f2α, which is characterized by the reduction of double bonds 13 - 14, oxidation 15 - hydroxyl into ceton form and cutting β - oxidation of the side vasoconstriction of carboxylic acid.

Elimination

in vivo, about 95% of the dose is eliminated within 24 hours. About 75% of the dose is eliminated through feces and the rest through the urine.

Before taking Travatan Novartis eye drops dilate the glaucoma (2.5ml)

How to use

Only use to eye eye.

Pressing on the turbulent tube or closing your eyes after small eyes to reduce the whole body absorption of drugs used by eye small eyes, reducing adverse adverse reactions.

Do not small the drug exceeds 1 drop daily in (s).

When replacing another glaucoma eye treatment with Travatan, it is necessary to stop taking the drug and should start taking Travatan on the next day.

If you are taking more than one eye drops, the drugs should be used at least 5 minutes apart. Eye ointment is last used.

Patients need to remove the packaging to ensure the form of folding right before use for the first time.

To avoid the infection into the small tip of the drug and the solution, be careful not to let the medications of the vial touch the eyelids, the area around the eyes or any surface. Close the lid of the vial when not in use.

Dosage

In adults, the elderly

Put 1 drop of small travatan eye solution into the conjunctiva bag of the eye 1 time/day. Achieve optimal effect if taking the drug in the evening.

Do not use Travatan more than 1 time/day because there is evidence that the use of similar drugs Prostaglandin often can reduce the effect of glaucoma.

Travatan can be used in combination with other eye medications to lower the lower eye pressure.

In children

Safety and effectiveness of Travatan treatment in patients under the age of 18 have not been set up, not recommended for these subjects.

In patients with liver or renal failure

Travatan eye solution has been studied in patients with mild to severe liver failure and in patients with mild to severe renal impairment (creatinine clearance to 14 ml/minute). There is no need to adjust the dose in these patients.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? It is less likely to occur poisoning when taking over the overdose.

When the toner is overdose, wash your eyes with warm water to remove medicine. If suspected of overdose by oral, symptomatic treatment and supportive treatment.

What to do when forgetting a dose? Do not put this solution exceeding 1 drop daily in (s).

Side Effects

Common, ADR> 1/100

eye disorders: eye congestion; Eye pain, itchy eye, dry eyes, eye irritation, increased iris, uncomfortable in the eyes.

Uncommon, 1/1000

The immune system: hypersensitivity, seasonal allergies.

Nervous system: headache , market reduction.

Eye disorders: corneal slip, spotted keratitis, keratitis, iritis, vision, conjunctivitis, prevent inflammation, lash inflammation, blurred vision, fear of light, eyelashes, cataracts, eyelids around the eyelids, eye rust, scaly eyelash

Respiratory system: stuffy nose, itchy throat.

Rare, 1/10000 ≤ ADR

Nervous system: dizziness, taste disorders.

Eye disorders: Ivanitis, iritis, lashes, herpes virus in the eyes, seed inflammation, conjunctivitis, eye inflammation ... Heart: Heart rate decreases, brushing chest drum, irregular heartbeat. vascular disorders: hypertension, systolic hypertension, hypotension, diastolic blood pressure decreases.

Respiratory system: asthma, shortness of breath, cough, allergic rhinitis , throat pain, nose dryness, respiratory disorders.

Digestive system: Gastrointestinal ulcer, digestive disorders, dry mouth, constipation.

Skin: Allergic dermatitis, erythema, skin color change, eyelash loss, eyebrows, hair color change ...

musculoskeletal: musculoskeletal pain, joint pain.

Systemic: weakness.

Instructions on how to handle ADR:

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindications

Hypersensitivity to the active ingredient or any excipients of the drug.

Precautions when using

Travoprost can slowly change the eye color by increasing the number of melanin particles (pigment seeds) in pigment cells. Before conducting treatment, it is necessary to notify the patient about the possibility of permanent change of eye color. The only treatment of one eye can lead to a difference in color between the eyes permanently. Long -term effects on pigment cells and any consequences are not known. The change in iris occurs slowly and may not be recognized for several months to several years. The eye color change is mainly observed in patients with mixed iris (blue brown, brown, yellow brown and green brown). However, this phenomenon is also observed in brown eye patients. Typically, the brown pigment around the pupil spreads in the direction of Dong Tam towards the peripheral side of the eye, but the entire iris or part of the iris can turn brown. After stopping treatment, no more brown iris pigmentation.

In control clinical trials, 0.4% of patients using Travoprost are related to tanning around the eye sockets and eyelids.

Travoprost may slowly change eyelashes in the eye with medication. These changes have been observed in ½ of the number of patients, including increasing length, thickness, pigmentation, and the number of eyelashes. It is not known the mechanism of changing their eyelashes and long -term consequences.

Change the eye sockets and eyelashes including the depth of the eyelid groove seen in the same drugs as prostaglandin.

In monkeys, Travatan causes a bit of wider cracking in the eyelids. However, this effect is not seen in clinical trials and is thought to be depending on species.

Inexperienced in using Travatan in the case of inflamed eyes, new vascular disease, closed angle glaucoma, narrow -angle glaucoma or congenital glaucoma and only limited experience in thyroid eye diseases, open -angle glaucoma disease in patients with artificial lenses and in pigmented diseases or glaucoma fake glass bags. Therefore, careful use of Travatan in patients with eye inflammation or at risk of irocyllitis/Ivelemia.

The point of the point has been reported when treated with similar drugs Prostaglandin F2α. Precautions in patients without a lens, patients with artificial lenses have torn in the back of the room or the room glass, the patient knows that there is a risk of royal throat.

Avoid contacting Travatan with skin in rabbits, Travoprost absorbs through the skin.

prostaglandin and similar drugs prostaglandin are biological active substances that can be absorbed through the skin. Pregnant or pregnant women should have appropriate preventive measures to avoid direct exposure to the amount of drugs in the vial. In case of contact with a significant part of the amount of medicine in the vial, it is necessary to wash the area that has been exposed immediately.

Travatan contains propylene glycol and polyoxyethylenylene hydrogenated castor oil that can cause skin irritation.

Patients need to be instructed to remove contact lenses before young Travatan and wait at least 15 minutes before wearing again.

The ability to drive and operate machinery

Travatan does not affect or affect the ability to drive and operate machinery. However, temporary blurring or other visual disorders may affect the ability to drive or operate machinery. If you look blurred after small eyes, you must wait until you see it clearly before you can drive or operate machinery.

Pregnancy

Travatan should not be used for women who are likely to get pregnant unless effective contraception.

Travoprost has harmful pharmacological effects on pregnancy, fetus/infant. In vivo studies with Travoprost showed reproductive toxicity.

Do not use Travatan during pregnancy unless really necessary.

Breastfeeding period

It is unknown whether Travoprost or its metabolites used on the spot are excreted in breast milk. In Vivo studies show that Travoprost and its metabolites excrete into breast milk. Do not recommend using Travatan for nursing women.

Drug interaction

studies on drug interaction have not been done. However, there is no clinical interaction.

Storage

Store drugs at temperatures not exceeding 30 ° C.

Throw away the vial after opening the lid of the vial for the first time.

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