Trifungi Pymepharco treatments for Candida Fungal Introduction - Throat (1 blister x 4 tablets)

Dosage form Box of 1 blister x 4 tablets
Specifications Itraconazole

Ingredient

Composition information	Content
Itraconazole	100mg

Uses

Indications

Trifungi drug are indicated in the following cases:

Fungal infection Candida in the mouth - throat, vulva - vagina.

tinea, fungal infections such as fungal skin, inguinal skin, body skin, interstitial skin.

Nail mushrooms, toenails.

Organs infection due to Aspergillus and Candida, Cryptococcus, Histoplasma, Sportoothrix, Paracoccioides, Blastomyces.

Maintain treatment: In patients AIDS to prevent the potential infection recurrence.

Preventing fungal infection during prolonged neutropenia.

Pharmacy

ITraconazole is a fungal synthetic triazol that works better than ketoconazole for some mushrooms, especially for Aspergillus spp .. The drug also works against Coccidioides, Cryptococcus, Candida, Histoplasma, Histoplasma, Histoplasma, Histoplasm Sportotrichosis

pharmacokinetics

Itraconazole is well absorbed when drinking immediately after meals or drinking with food. Relatively oral bioavailability of capsules compared to oral solution is over 70%. Itraconazole's solubility increases in acidic environment. Serum peak concentration reaches 20 mcg/l, 4 - 5 hours after taking a dose of 100 mg at hunger, increasing to 180 mcg/l when drinking with food.

over 99% of the drug is associated with protein, mainly with albumin, only about 0.2% of the drug in free form. The drug dissolves well in lipids, the concentration in tissues is much higher in the serum. Itraconazole converts the liver into many substances and then excreted through bile or urine. One of the metabolites is Hydroxyitraconazole that has anti -fungal effects and has double serum concentration of ITRAConazole concentration in a stable state.

3 - 18% of oral dose is excreted in feces in a constant form. About 40% of the dose is excreted in the urine in the form of metabolic compounds that are no longer active. A small amount excreted through the horny and hair layer.

iTraconazole is not excluded by a cup. The sale time after taking 1 dose of 100 mg is 20 hours, may be longer when taking high daily doses.

Before taking Trifungi Pymepharco treatments for Candida Fungal Introduction - Throat (1 blister x 4 tablets)

How to use

Take medicine immediately after eating.

Dosage

Vaginal Candida infection - Vaginal

Take a dose of 2 capsules 2 times/day, used for 1 day; or 2 capsules 1 time/day, used for 3 days.

versicide

Take the dose of 2 capsules once a day, used for 7 days.

Dermatological mushrooms

Use 2 tablets x 1 time/day, use for 7 days or 1 capsule 1 time/day, used for 15 days.

High horny areas such as fungal infections in the soles of the feet, palms

Use 2 tablets 2 times/day, use for 7 days or 1 capsule 1 time/day, used for 30 days.

Candida infection in the mouth - throat

Use 1 tablet 1 time/day, use for 15 days.

In AIDS patients, organ transplantation or neutropenia: take a dose of 2 capsules once a day, used for 15 days.

Mushrooms

Take the dose of 2-3 batches, 7 days each, drink 4 tablets, 2 tablets in the morning, 2 tablets.

The treatment is always separated by 3 weeks without drugs. Or Treatment of Lien Lien 2 tablets 1 time/day, used for 3 months.

Organs infection

Aspergillus infection: 2 capsules 1 time/day, used for 2-5 months, if the disease spreads can increase the dose of 2 capsules 2 times/day.

Candida fungal infection: 1-2 capsules 1 time/day, used for 3 weeks to 7 months.

Cryptococcus fungus outside the meninges: 2 capsules x 1 time/day, used for 2 months to 1 year.

Cryptococcus meningitis: 2 capsules 2 times/day. Maintenance treatment: 2 capsules x 1 time/day.

Histoplasma infection and blastomyces: 2 tablets x 1-2 times/day, an average use time of 8 months.

Maintain treatment in AIDS

Take the dose of 2 capsules/time x 1 time/day.

Prophylaxis in neutropenia

Take the dose of 2 capsules/time x 1 time/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

In case of overdose use, symptomatic treatment and use of supportive measures, gastric lavage if necessary. There is no specific antidote. It is not eliminated Itraconazole by hemorrhage.

What to do when forgetting a dose? If it is nearly time to take the next dose, skip the forgotten dose and take medicine at the next recommended dose. Do not take double dose to compensate for the forgotten dose.

Side Effects

When using trifungi , you may experience unwanted effects (ADR).

When treated short, unwanted effects can occur, nausea, abdominal pain, headache and indigestion. When long -term treatment in patients had hidden diseases and had to use many drugs at the same time, the unwanted effect happened more.

Common

Dizziness headache, nausea, abdominal pain, constipation, digestive disorders .

Allergic reactions such as itching, external rash, urticaria and angioedema; Stevens - Johnson syndrome ; Menstrual disorders; Increasing liver enzymes with recovery, hepatitis, especially after long -term treatment. Very rare peripheral neuropathy.

Notice the unwanted physician when using the drug.

Instructions on how to handle ADR:

Periodically monitor liver enzymes, stop the drug if abnormal and signs of hepatitis.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Trifungi drug contraindicated in the following cases:

Patients with hypersensitivity to drugs or ingredients of the drug.

Do not use drugs in pregnant or nursing women, only use when internal fungal infections threaten life and when the benefits are higher than the risk of harmful to the fetus.

Simultaneously with the drug: terfenadin , Astermizol, cisaprid , triazolam and midazolam oral.

Precautions when using

Patients with liver failure

Despite the short -term treatment, the drug does not disrupt liver function, but it should not be used for people with a history of liver or liver disease that has been poisoned by other drugs. When long -term treatment (over 30 days) must periodically check the liver function.

Patients with renal failure

Biological use when taking Itraconazole decreases in patients with renal failure. ITRACONAZOL concentration should be checked in plasma concentrations and appropriate dose adjustments.

In the body -body candidiasis infection due to Fluconazole resistant Candida, it may not be sensitive to otraconazole. Therefore, it is necessary to check the sensitivity of itraconazole before treatment.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery. However, in some cases, dizziness, headache. Therefore, when encountering the above symptoms, you should not drive and operate machinery while using the drug.

Pregnancy

only use the drug when really necessary.

Breastfeeding period

Medicinal interaction

Itraconazole is an inhibitor of the cytochrome p450 3A enzyme system, so avoid simultaneous use of otraconazole with drugs metabolized by the enzyme system because the concentration of these drugs in plasma can increase leading to increased and prolonged treatment effects and unwanted effects.

Terfenadin, Astemizol, Cisaprid can increase in plasma concentrations if taken with itraconazole, which can easily lead to heart arrhythmia. Contraindications for this combination.

Diazepam, Midazolam, Triazolam orally are contraindicated with ITRAConazol. If Midazolam is intravenously in the surgery for surgery, it must be monitored carefully because the sedative effect can last.

iTraconazole is used with warfarin to increase the anticoagulant effect of this substance. Prothrombin should be monitored in patients to reduce the dose of warfarin if needed.

With calcium blockers can be met with edema, tinnitus. Need to reduce the dose if needed.

With HMG-CAA Reductase reducing cholesterol-reducing groups such as lovastatin, atorvastatin, simvastatin, pravastatin ..., iTraconazole may increase the concentration of these drugs in the blood. To reduce the risk of myocarditis or muscle disease, these drugs may be suspended if it is necessary to treat systemic fungi.

Digoxin, used with otraconazole, plasma concentrations will increase. Must monitor to adjust the dose.

Hypoglycemia occurs when taking anti -diabetic drugs with Azol antifungal drugs. Therefore, it is necessary to closely monitor blood sugar levels to adjust the dose of anti -diabetic drugs.

iTraconazole needs gastric acid acid environment for good absorption. So if taken with acid resistance, or H2 resistant (such as cimetidin, ranitidin) or omeprazol, sucralfate, biological use of itraconazole will be significantly reduced, loss of anti -fungal treatment effect. So should not be used simultaneously or you must replace itraconazole with fluconazole or amphotericin b.

Enzyme induction drugs such as rifampicin, isoniazid, phenolbarbital, phenytoin reduces the concentration of otraconazole in plasma. Therefore, other antifungal drugs should be replaced if it is considered to be treated with isoniazid or rifampicin.

Storage

In a dry, cool place (under 30 ° C). Avoid light.

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