Trimetazidine 35mg Stella Pharm medicine supports stable angina symptoms (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Trimetazidine

Ingredient

Composition information	Content
Trimetazidine	35mg

Uses

indications

Trimetazidine drugs are indicated in the following cases:

Indications for adults in supportive treatment for symptomatic patients with stable angina patients who are not fully controlled or in tolerance with other angina treatment therapies. PS of Aub Enuzone

ATC code: C01EB15.

Mechanism of action

Trimetazidine inhibits the oxidation of fatty acids by inhibiting 3-ketoacyl-coa thiolase enzyme.

In ischemic cells, energy obtained during oxidation of glucose needs to consume less oxygen than the oxidation beta.

Promoting glucose oxidation will help optimize cell energy processes, thus maintaining appropriate energy metabolism during anemia.

Pharmacological effects

In patients with local myocardial ischemia, trimetazidine acts as a metabolic substance, which helps conserve intracellular phosphate energy in myocardial cells at a high level.

Trimetazidine has an anti -myocardial anti -myocardial effect but does not affect hemodynamics.

pharmacokinetics

by oral, maximum concentration reaches 5 hours after taking the drug. Over 24 hours, plasma concentration is still maintained at a concentration greater than or equal to 75% of the maximum concentration in 11 hours.

The equilibrium state is reached at the latest at 60 hours.

Trimetazidine pharmacokinetic properties are not affected by food.

The apparent distribution integral is 4.8 liters/kg, trimetazidine binding low protein: the measured value in vitro is 16%.

Trimetazidine is excreted mainly in urine in the form of unprovered. The sale time of Trimetazidine 35 mg averages 7 hours in young volunteers and 12 hours for people over 65 years old.

The total clearance of trimetazidine due to the renal clearance is the main thing that directly involves the clearine clearance and the liver clearance at a lesser level, decreasing with age.

Specific clinical research is conducted in the elderly, with a dose of 2 capsules daily use, analyzed by dynamic population method, showing an increase in plasma concentration.

Before taking Trimetazidine 35mg Stella Pharm medicine supports stable angina symptoms (6 blisters x 10 tablets)

How to use

oral tablets. Take the tablet with a glass of water.

Dosage

Normal dose: 1 capsule 2 times/day, drink with meals.

Patients with average renal impairment (Creatinine clearance [30 - 60] ml/min): The recommended dose is 1 capsule in the morning, drink with meals.

Elderly patients: Elderly patients may have a higher level of trimetazidine sensitivity than normal due to the decline in kidney function by age. For patients with average renal impairment (clearine clearance 30 - 60 ml/min), the recommended dose is 1 capsule in the morning, drink with meals.

Be careful when calculating the dose for elderly patients.

Children: The safety and effectiveness of trimetazidine for children under 18 years of age has not been evaluated. There is currently no data on this patient object.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using trimetazidine drugs you may experience unwanted effects (ADR):

Common (1/100 ≤ ADR

Nervous system

Common: Dizziness, headache. Sleep disorders (insomnia, drowsiness).

heart

Rare: suspense, extra mind, fast heartbeat.

circuit

Rare: Aortic hypotension, hypotension can be combined with discomfort, dizziness or fall, especially in patients who are being treated with anti -hypertension drugs, flushing.

Common: abdominal pain, diarrhea, indigestion, nausea and vomiting.

Common: ban, itching, urticaria.

Common: weakness.

Unknown frequency: granulocytosis, thrombocytopenia, thrombocytopenia.

Unknown frequency: hepatitis.

Instructions on how to handle ADR:

Notify the physician with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Trimetazidine drugs contraindicated in the following cases:

Hypersensitivity to the active ingredient or any excipients in the finished formula.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Due to the lack of clinical data and for safety reasons, do not use trimetazidine for pregnant and lactating women. In suspicious cases, patients need to be taken to a neurologist for appropriate examination. These cases occur and often recover after stopping the drug. Most patients recover after stopping the drug for about 4 months. If Parkinson's symptoms continue to happen for more than 4 months after stopping the drug, consulting neurologists.

The effect of the drug on the ability to drive and operate machines

trimetazidine can cause symptoms such as dizziness and drowsiness, so it can affect the ability to drive and operate machinery.

Use drugs for women during pregnancy and lactation

Do not use trimetazidine for pregnant and lactating women.

Interactive drug

no.

Tyeum of drugs

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.