Trimetazidine Stella 20mg medicine for stable angina treatment (2 blisters x 30 tablets)

Dosage form Box of 2 blisters x 30 tablets
Specifications Trimetazidine

Ingredient

Composition information	Content
Trimetazidine	20mg

Uses

Indications

Trimetazidin Stella is indicated for adults such as supplementary therapy to support existing treatments to treat symptoms in stable angina patients not fully controlled or non -tolerated patients with other treatments Other tensions .

Pharmacokology

Pharmacological group: other cardiovascular drugs.

Code ATC: C01EB15

Trimetazidine inhibits the beta oxidation of fatty acids by inhibiting 3 -ketoacyl - coa thiolase enzymes. In ischemic cells, energy obtained during oxidation of glucose needs to consume less oxygen than the oxidation beta. Promoting glucose oxidation will help optimize cell energy processes, thus maintaining appropriate energy metabolism during anemia.

In patients with local heart anemia, trimetazidine acts as a metabolite, which helps conserve high intracellular energy levels in myocardial cell. Trimetazidine has anti -anemia effect but does not affect hemodynamics.

pharmacokinetic

trimetazidine when taken is absorbed quickly and reaches the peak in plasma within 2 hours from drinking. The maximum concentration of the drug in plasma, after the only dose of Trimetazidine 20 mg, reaches about 55 ng/ml. The equilibrium of the medication in the blood is reached from 24 - 36 hours after repeating a dose and is very stable during treatment. With the distribution volume of 4.8 liters/kg shows the good diffusion level of the drug to the tissues. Low protein mounting ratio, the measured value in vitro is 16%. Trimetazidine waste sale time is 6 hours. The drug is excreted mainly in urine in the form of unprovered.

Before taking Trimetazidine Stella 20mg medicine for stable angina treatment (2 blisters x 30 tablets)

How to use

Take oral, use with meals.

Dosage

The usual dose: Each time 1 tablet x 3 times/day.

Patients with average renal insufficiency (creatinine clearance [30 - 60] ml/minute)

Dosage recommended is 1 tablet x 2 times/day, morning and evening.

Elderly patients

Elderly patients may have a higher level of trimetazidine sensitivity than normal due to the renal function impairment by age. For patients with average renal impairment (creatinine clearance [30 - 60] ml/min) recommended dose is 1 tablet x 2 times/day, morning and evening.

Be careful when calculating the dose for elderly patients.

Children

The safety and effectiveness of trimetazidine for patients under 18 years of age has not been evaluated. There is currently no data on this patient object.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Overdose

There are very little information about trimetazidine overdose.

How to handle

Should treat symptoms.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using trimetazidin stella 20 mg , you may experience unwanted effects (ADR).

Common (1/100 ≤ ADR

Neurological: dizziness, headache.

digestive: abdominal pain, diarrhea , indigestion, vomiting and vomiting. Systemic: weakness.

Skin: rash, itching, urticaria.

Rare (1/10000 ≤ ADR

Disorders on the cardiovascular system: Brushing the chest, outsiders, thrilling, fast heartbeat. Aortic hypotension, vertical hypotension, which can lead to discomfort, dizziness or fall, especially in patients being treated with anti -hypertension drugs, flushing.

Unknown

Symptoms Parkinson (Run, slow movement and difficulty, muscle tone), unstable gait, vacuum syndrome, other relevant dyslunis, often recovered after stopping the drug.

Sleep disorders (insomnia, drowsiness).

Constipation.

Excavity of the acne pustules (AGEP), Evaluation.

A blood cell loss, thrombocytopenia, thrombocytopenic banner. hepatitis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Trimetazidin Stella contraindicated in the following cases:

Hypersensitivity to the active ingredient or any excipients of the drug. (Colonel: Lactose Monohydrate, Corn Starch, Povidon K30, Croscarmes Sodium, Magnesi Stearat, Hypromello 6 CPS, Macrogol 6000, TALC, PonCeau 4R.)

Parkinson patient, Parkinson's symptoms, tremor, vacuum syndrome and other relevant movement disorders.

Severe renal failure (Creatinine clearance

Precautions when using

trimetazidine can cause or worsen Parkinson's symptoms (Run, slow movement and difficulty, increase muscle tone). Therefore, patients, especially elderly patients, need to be checked and monitored regularly. In suspicious cases, patients need to be taken to neurologists for appropriate examination.

When encountering movement disorders such as Parkinson's symptoms, vacuum syndrome, tremor, unstable gait, immediately stop using trimetazidine.

These cases are rarely occurring and often recover after stopping the drug. Most patients recover after stopping the drug for about 4 months. If Parkinson's symptoms continue to happen for more than 4 months after the drug is stopped, consulting neurologists.

may experience an outfit, unstable gait or hypotension, especially in patients who are taking drugs to treat hypertension.

Be careful when prescribing trimetazidine for patients with high sensitivity levels such as:

Patients with average renal failure.

Patients over 75 years old.

Trimetazidine Stella 20 mg contains Ponaceau 4R excipients that can cause allergic reactions.

Trimetazidine Stella 20 mg contains lactose excipients. This drug should not be used for patients with rare genetic problems galactose intolerance, total lactase enzyme deficiency or glucose - galactose.

The ability to drive and operate machinery

trimetazidine can cause symptoms such as dizziness and drowsiness, so it can affect the ability to drive and operate machinery.

Pregnancy

Avoid for pregnant women.

Breastfeeding period

Medicinal interaction

There has been no interaction with any drug. Trimetazidine is not a drug that causes induction nor is not an enzyme that inhibits the liver metabolic enzyme in the liver and thus is more likely to trimetazidine does not interact with many liver metabolic drugs. Need to be careful when coordinating with another drug.

Cavalry of the drug: Due to no studies on the correspondence of the drug, not mixing this drug with other drugs.

Storage

Store in closed packaging, dry place, avoid light. The temperature does not exceed 30 ° C.

Other drugs

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