Trimetazidine Stella 35mg medicine for stable angina treatment (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Trimetazidine

Ingredient

Composition information	Content
Trimetazidine	35mg

Uses

Indications

Trimetazidine Stella is indicated for adults such as symptomatic treatment support in stable angina patients with unwavering or intolerant with other angina therapy.

Pharmacokology

Pharmacological group: other cardiovascular drugs.

Code ATC: C01EB15.

Trimetazidine inhibits the beta oxidation of fatty acids by inhibiting 3 -ketoacyl - coa thiolase enzymes. In ischemic cells, energy obtained during oxidation of glucose needs to consume less oxygen than the oxidation beta. Promoting glucose oxidation will help optimize cell energy processes, thus maintaining appropriate energy metabolism during anemia.

In patients with local heart anemia, trimetazidine acts as a metabolite, which helps conserve high intracellular energy levels in myocardial cell. Trimetazidine has anti -anemia effect but does not affect hemodynamics.

pharmacokinetics

by oral, maximum concentration reaches an average of 5 hours after taking the drug. Over 24 hours, plasma concentration is still maintained at a concentration greater than or equal to 75% of the maximum concentration in 11 hours.

The equilibrium state is reached at the latest at 60 hours.

Trimetazidine pharmacokinetic properties are not affected by food.

The apparent distribution integral is 4.8 liters/ kg, trimetazidine binding low protein: the measured value in vitro is 16%.

Trimetazidine is excreted mainly in urine in the form of unprovered. The sale time of Trimetazidine 35 mg averages 7 hours in young volunteer and 12 hours for people over 65 years old.

The total clearance of trimetazidine due to the renal clearance is the main thing that directly involves the clearine clearance and the liver clearance at a lesser level, decreasing with age.

Specific clinical research is conducted in the elderly, with a dose of 2 capsules daily use, analyzed by dynamic population method, showing an increase in plasma concentration.

Before taking Trimetazidine Stella 35mg medicine for stable angina treatment (3 blisters x 10 tablets)

How to use

Take oral, use with meals.

Dosage

Normal dose: 1 tablet of 1 tablet twice a day.

Patients with average renal failure (creatinine clearance [30 - 60] ml/ min):

recommended dose is 1 tablet in the morning.

Elderly patients:

Elderly patients may have a higher level of trimetazidine sensitivity than normal due to the decline in kidney function by age. For patients with average renal insufficiency (creatinine clearance [30 - 60] ml/min) recommended dose is 1 tablet in the morning.

Be careful when calculating the dose for elderly patients.

Children:

The safety and effectiveness of trimetazidine for patients under 18 years of age has not been evaluated. There is currently no data on this patient object.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Overdose

There are very little information about trimetazidine overdose.

How to handle

Should treat symptoms.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using trimetazidine stella , you may experience unwanted effects (ADR).

Common (1/100

Nervous system

Common: Dizziness, headache . Sleep disorders (insomnia, drowsiness).

heart

Rare: suspense, extra mind, fast heartbeat.

circuit

Rare: Aortic hypotension, hypotension can be combined with discomfort, dizziness or fall, especially in patients treated with anti -hypertension drugs, flushing.

Common: abdominal pain, diarrhea , indigestion, nausea and vomiting.

Common: ban, itching, urticaria.

Common: weakness.

Blood and lymphatic system

Unknown frequency: granulocytosis, thrombocytopenia, thrombocytopenia.

Unknown frequency: Hepatitis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Trimetazidine Stella contraindicated in the following cases:

Hypersensitivity to the active ingredient or any excipients in the finished formula.

Patient Parkinson , Parkinson's symptoms, Run, vacuum syndrome and other relevant movement disorders.

Severe renal failure (Creatinine clearance

Precautions when using

trimetazidine can cause or worsen Parkinson's symptoms (Run, slow movement and difficulty, increase muscle tone). Therefore, patients, especially elderly patients, need to be checked and monitored regularly. In suspicious cases, patients need to be taken to neurologists for appropriate examination.

When encountering movement disorders such as Parkinson's symptoms, vacuum syndrome, tremor, unstable gait, immediately stop using trimetazidine.

These cases are rarely occurring and often recover after stopping the drug. Most patients recover after stopping the drug for about 4 months. If Parkinson's symptoms continue to happen for more than 4 months after the drug is stopped, consulting neurologists.

may fall due to unstable gait or hypotension, especially in patients who are taking medications for hypertension.

Be careful when prescribing trimetazidine for patients with high sensitivity levels such as:

Patients with average renal failure.

Patients over 75 years old.

The ability to drive and operate machinery

trimetazidine can cause symptoms such as dizziness and drowsiness, so it can affect the ability to drive and operate machinery.

Pregnancy

Due to the lack of clinical data and for safety reasons, do not use trimetazidin for pregnant women.

Breastfeeding period

Due to the lack of clinical data and for safety reasons, do not use trimetazidin for breastfeeding.

Medicinal interaction

Cavalry of the drug: Because there is no studies on the correspondence of the drug, not mixing this drug with other drugs.

Storage

Store in closed packaging, dry place, avoid light. The temperature does not exceed 30 ° C.

Other drugs

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