Trimoxtal Minh Hai medicine treated infections in the mouth and respiratory tract (2 blisters x 7 tablets)

Dosage form Box of 2 blisters x 7 tablets
Specifications Amoxycillin, sulbactam

Ingredient

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Composition information	Content
Amoxycillin	875mg
Sulbactam	125mg

Uses

Indications

trimoxtal 875/125 are indicated in the following cases:

Infection of the mouth and respiratory tract (especially in severe or recurrent cases): otitis media, sinusitis, tonsillitis, sore throat, laryngitis, laryngitis, pneumonia, bronchitis ...

Urinary tract infections: Cases of recurrent or complicated cystitis.

Skin and soft tissue infections: lymphatic vasculitis, cellular inflammation, open or tissue wounds, teeth and mouth abcesses due to staphylococcus aureus.

Chemical studies with non-cell bacteria have proved that sulbactam is capable of inactivating the inactivity that does not recover most of the important beta-lactamase enzymes of penicillin-resistant bacteria. Sulbactam has significant antibacterial activity for Neisseriaceae, Acinetobacter Calcoaceticus, Bacteroides spp, Branhamella Catatrhalis and Pseudomonas Cepacia.

The combination of sulbactam and amoxicillin has the feature of killing drugs that are sensitive to drugs by inhibiting the mucopeptide biosynthesis of the cell wall.

The drug has a broad antibacterial spectrum for both gram -positive and gram -negative bacteria, including: Staphylococcus aureus and S. Epidermidis (including penicillin resistance and some methicillin resistance), Streptococcus Pneumoniae.

Pharmacokinetics

absorption

Take medicine after eating does not affect the whole body. The peak concentration of amoxicillin plasma after taking the combined drug is 2 times higher than that of the oral amoxicillin.

Distribution

Sulbactam and Amoxicillin diffuse easily into most tissues and body fluids. The drug is less penetrated into the brain and cerebrospinal fluid unless there is meningitis. The drug also passes through the fetus fence and is excluded into breast milk.

Elimination

Sulbactam's disposal time is 0.75 hours and Amoxicillin is 1 hour, with the advantage of from 50% to 75% of intact excreted drugs through urine.

Before taking Trimoxtal Minh Hai medicine treated infections in the mouth and respiratory tract (2 blisters x 7 tablets)

How to use

oral medication.

Dosage

Usual adult and children over 12 years old

Take 1 capsule/time, 3 times a day.

Patients with renal failure

Adult dose

Creatinine clearance

dose

No dose adjustment

Initial dose 1 g, then every 12 hours of injection 500 mg.

Initial dose 1 g, then 500 mg/day.

Creatinine clearance

dose

No dose adjustment

25 mg/kg, 2 times/day

25 mg/kg/day

Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? In case of overdose, stop taking the drug immediately and use supportive treatments. Can cause vomiting, gastric lavage if newly overdosed, unless contraindgication.

There is no specific antidote, which can be removed by hemolysis.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Common, ADR> 1/100

Digestive system: Nausea, vomiting, diarrhea , indigestion.

Systemic: allergies.

Uncommon, 1/1000

Digestive: Nausea, vomiting, diarrhea.

Hypersensitivity reaction: Red rash, burning and urticaria, especially Stevens - Johnson syndrome

Rare, ADR

Liver: slight increase SGOT.

Central nerve: agitation, struggle, anxiety, insomnia, confusion, behavior change and/or dizziness. Blood: Anemia, thrombocytopenia, thrombocytopenic decreased hemorrhage, Eosin leukemia, leukopenia, granulocytosis

Instructions on how to handle ADR

Amoxicillin's undesirable reactions in the gastrointestinal tract, in the blood often disappear when stopping treatment.

urticaria, other types of rash and serum -like reactions can be treated with antihistamine, and if necessary, using systemic corticosteroid therapy. However, when such a reaction occurs, it is necessary to stop using amoxicillin, unless there is a physician's opinion in special cases, life -threatening that only amoxicillin can be resolved.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Contraindicated

Trimoxtal 875/125 medicine in the following cases:

Patients with a history of allergies to penicillin or cephalosporins and sulbactam or any ingredients of the drug.

There is a history of gastrointestinal disease.

Infections with mononucleemia.

Infection of Herpes virus.

is being treated with Allopurinol.

Pregnant and lactating women

Children under 12 years old.

Caution when using

must periodically check the liver and kidney function during long -term treatment.

There may be severe hypersensitivity reactions in patients with a history of allergies to penicillin or other allergens, so it is necessary to carefully investigate the history of allergies to penicillin, cephalosporin and other allergens.

If the allergic reaction occurs such as erythema, edema, anaphylaxis, Stevens - Johnson syndrome, amoxicillin must be stopped and immediately treated emergency treatment with adrenalin, oxygen breathing, intravenous corticosteroid therapy, including internal trachea and never being treated with penicilin or cephalosporin again.

The ability to drive and operate machinery

has not found documents in the pharmacy.

pregnancy

Amoxicillin safely used during pregnancy has not been clearly defined. Therefore, only this drug is needed during pregnancy. However, there is no evidence of harmful effects for the fetus when using amoxicillin for pregnant women.

Lactation period

Because amoxicillin is excreted in breast milk, it is necessary to be cautious when taking the drug during breastfeeding.

Medicinal interaction

Absorption of Amoxicillin is not affected by food in the stomach, so it can be taken before or after meals.

Nifedipine increases amoxicillin absorption.

When using alopurinol along with amoxicillin or ampicillin will increase the ability of ampicillin, amoxicillin.

There may be antagonists between amoxicillin and bactericidal substances such as chloramphenicol, tetracyclin.

Storage

Store at a temperature not exceeding 30 ° C.

Other drugs

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