Trimoxtal Mipharmco treatments for infection (2 blisters x 7 tablets)

Dosage form Box of 2 blisters x 7 tablets
Specifications Amoxicillin, sulbactam

Ingredient

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Composition information	Content
Amoxicillin	500mg
Sulbactam	500mg

Uses

Indications

Trimoxtal 500/500 drugs are indicated in the following cases:

Treatment of the following cases of infection:

Infection of the mouth and respiratory tract (especially in severe or recurrent cases): otitis media, sinusitis, tonsillitis, sore throat, laryngitis, tracheitis, pneumonia, bronchitis ... Softness: Lymphatic vasculitis, cellular inflammation, open wounds or tissue loss, tooth root and oral area due to staphylococcus aureus.

Chemical studies with non-cell bacteria have proved that sulbactam is capable of inactivating the inactivation of the most important beta-lactamase yeast of penicillin resistant bacteria. Sulbactam has significant antibacterial activity for Neisseriaceae, Acinetobacter Calcoaceticus, Bacteroides spp, Branhamella Catatrhalis and Pseudomonas Cepacia.

Microbiological studies on anti -drug bacterial lines confirm sulbactam are capable of protecting penicillin and cephalosporin that are not destroyed by bacteria and has a significant co -effect with penicillin and cephalosporin. Because sulbactam is also associated with some penicillin bond proteins, for some sensitive bacteria, using a combination of sulbactam-amoxicillin will be more effective than just one type of beta-lactamase.

The combination of sulbactam and amoxicillin has the feature of killing drugs that are sensitive to drugs by inhibiting the mucopeptide biosynthesis of the cell wall.

The drug has a wide antibacterial spectrum for both gram -positive and gram -negative bacteria, including Staphylococcus aureus and S. Epidermidis (including penicillin resistance and some methicillin resistance), Streptococcus pneumoniae.

Dynamic pharmacokinetics

Take medicine after eating does not affect the whole body. The peak concentration of amoxicillin plasma after taking the combined drug is 2 times higher than that of the oral amoxicillin. Sulbactam's disposal time is 0.75 hours and amoxicillin is 1 hour, with the advantage of 50% to 75% of intact excreted drugs through urine.

increased waste time in the elderly and people with renal failure. Probenecid reduces the ability to excrete through the renal tubules of both amoxicillin and sulbactam. Therefore, simultaneous use of probenecid and drugs increase and prolong the concentration of amoxicillin and sulbactam in the blood.

Sulbactam and Amoxicillin diffuse easily into most tissues and body fluids. The drug is less penetrated into the brain and cerebrospinal fluid unless there is meningitis.

About 20% amoxicillin and about 40% sulbactam are bound to the protein of plasma.

Most sulbactam and amoxicillin are excreted in the urine.

The drug also passes through the fetus fence and is given an expression into breast milk.

Before taking Trimoxtal Mipharmco treatments for infection (2 blisters x 7 tablets)

How to use

oral medication.

Dosage

Usual adults and children over 12 years:

Take 1 capsule/time, 3 times a day.

Patients with renal failure

Adult dose:

Creatinine clearance

dose

30 ml/minute

No need to adjust the dose

from 10 to 30 ml/minute

Initial dose 1 g, then every 12 hours of injection 500 mg

Initial dose 1 g, then 500 mg/day.

Creatinine clearance

dose

30 ml/minute

No need to adjust the dose

from 10 to 30 ml/minute

25 mg/kg, 2 times daily.

25 mg/kg/day.

Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? In case of overdose, stop taking the drug immediately and use supportive treatments. Can cause vomiting, thick wash if newly overdosed, unless contraindicated.

There is no specific antidote, which can be removed by hemolysis.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Trimoxtal 500/500, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Nausea, vomiting, diarrhea, indigestion, epigastric pain.

Uncommon, 1/1000

Allergic reactions: urticaria, rhyme, rash, respiratory disorders and rarer may experience anaphylaxis.

Interstitial nephritis. Hematology reaction: Anemia, platelet disorders, leukocytes. liver: liver dysfunction.

Candida infection in the mouth or in another position is a manifestation of bacterial balance transformation.

Rare Stevens-Johnson syndrome, diverse erythema and poisonous necrosis. Increase activity, anxiety, insomnia, behavior change.

There are some cases of fake bowelitis.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Trimoxtal medicine 500/500 contraindicated in the following cases:

Patients with a history of allergies to penicillin or cephalosporins and sulbactam or any ingredients of the drug.

There is a history of gastrointestinal disease.

Infections with mononucleemia.

Infection of Herpes virus.

being treated with Allopurinol.

Pregnant and lactating women.

Children under 12 years old.

Be cautious when used

Patients with drug treatment, may have fungal infections or other pathogenic bacteria (mainly due to pseudomonas or candidiasis). If superinfection appears should be discontinued and applied appropriate treatments.

During treatment may appear to increase the transaminase indicators of the liver, mainly glutamic-oxalacetic transaminase.

A slightly reduction in the concentration relationship between estriol and estrone with estradiol content in serum. The contraceptive support should be used for female patients who are applying Estrogen or Progestin contraception.

It is necessary to conduct periodic and periodic kidney function tests if used for prolonged drugs.

Caution for the elderly, children and pregnant or lactating people.

The ability to drive and operate machinery

has not found documents in the pharmacy.

Pregnancy

Precautions for pregnant women.

The period of breastfeeding

Caution for breastfeeding women.

Drug interaction

Timeless with Allopurinol increases the risk of skin allergies.

Probenecid may increase blood levels because this drug will be reduced in the renal tubules when used simultaneously.

chloramphenicol, macrolide, sulfonamide and tetracycline can hinder the bactericidal effect of penicillin.Clinical

amoxicillin can affect the value of total serum protein or a false positive reaction in the glucose test in urine with a color reaction. High amoxicillin levels can reduce blood glucose.

Storage

Store at temperatures below 30 ° C. Cool dry place, avoid light.

To be out of reach of children.

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