Trimpol MR 35mg Polfarmex medicine for stable angina treatment (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Trimetazidine

Ingredient

Composition information	Content
Trimetazidine	35mg

Uses

Indications

trimpol mR is appointed to adults in supplementary therapy/support for existing treatments to treat symptoms in patients with stable angina without adequate control, or non -tolerated patients with other angina treatment therapy.

Pharmacological

Trimetazidin active ingredient inhibits the oxidation of fatty acids by inhibiting the 3-ketoacyl-coa thiolase enzymes in ischemic cells, energy obtained during glucose oxidation needs less oxygen consumption than oxidative beta. Promoting glucose oxidation will help optimize cell energy processes, thus maintaining appropriate energy metabolism during anemia.

In patients with ischemic heart anemia, trimetazidine active ingredient acts as a metabolite, which helps conserve high intracellular energy levels in myocardial cell. The drug contains trimetazidine active ingredients that have anti -anemia but does not affect hemodynamics.

Pharmacokinetics

absorption

After drinking, trimetazidin is absorbed through the gastrointestinal tract. The maximum concentration of the drug in plasma is about 5 hours after taking the drug. The sustainable concentration of the drug in plasma is achieved after 60 hours and maintained during the treatment process. The interaction between the drug has not been seen.

Distribution

The ratio of trimetazidine is attached to plasma proteins about 16%. The drug is widely distributed to the tissue, the distribution of the drug is 4.8 I/kg.

Metabolism

The drug is not metabolized through the liver.

Elimination

Trimetazidin is excreted mainly in urine, in a constant form. The average disposal time is 7 hours.

Before taking Trimpol MR 35mg Polfarmex medicine for stable angina treatment (6 blisters x 10 tablets)

How to use

oral drugs, 2 times a day, breakfast and dinner.

Dosage

adults

01 capsule 35 mg/time x 2 times/day, with meals.

Special subjects

Patients with average renal insufficiency (creatinine clearance [30-60] ml/min)

recommended dose is 01 tablet 35 mg in the morning, with meals.

Elderly patients

Elderly patients may have a higher level of sensitivity to trimetazidine active ingredients than normal due to the decline in kidney function by age.

Be careful when calculating the dose for elderly patients.

Children

Safety and effectiveness of drugs containing trimetazidine active ingredients for patients under 18 years of age has not been evaluated. There is currently no data on this patient object.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Common, ADR> 1/100

Nervous system: dizziness, headache.

Digestive system: Nausea, vomiting, abdominal pain, diarrhea, indigestion.

Skin and subcutaneous tissue: rash, urticaria.

Systemic: weakness.

Uncommon, 1/1000

No report.

Rare, ADR

Cardiovascular: Brushing chest drums, nervousness, extra mind, fast heartbeat. Aortic hypotension, vertical hypotension, which can lead to discomfort, dizziness or fall, especially in patients being treated with anti -hypertension drugs, flushing.

Not determined frequency

Nervous system: Parkinson symptoms (Run, slow and difficult exercise, muscle tone), unstable gait, vacuum syndrome, other relevant movement disorders. Sleep disorders (insomnia, drowsiness).

Digestive system: constipation.

Skin and subcutaneous tissue: Excellent pustules (AGEP), Evaluation. blood and lymphatic system: granulocytosis, thrombocytopenia, thrombocytopenic rash.

Hepatitis: Hepatitis.

Instructions on how to handle ADR

Parkinson's symptoms, unstable gait, vacuum syndrome, other relevant movement disorders, often recovered after stopping the drug.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Contraindicated

Trimpol MR is contraindicated in the following cases:

Hypersensitivity to the active ingredient trimetazidin or any dozens is listed in the formula of product preparation.

Parkinson patients, Parkinson's symptoms, tremor, vacuum syndrome and other relevant movement disorders.

Severe renal failure (creatinine clearance

Caution when used

The drug is often recommended not to be used during breastfeeding.

trimpol mR is not prescribed to treat angina as well as to treat my muscle infarction or unstable angina during the hospital pre -hospital period and in the first days of hospitalization.

In the event of an angina occurrence, coronary heart disease must be re -evaluated and reconsidered the suitability of the treatment (medical treatment and may have to be re -vascular).

Trimpol mR can cause or worsen Parkinson's symptoms (Run, move slowly and difficult, increase muscle tone), so patients, especially elderly patients, need regular check and monitor. In suspicious cases, patients need to be taken to neurologists for appropriate examination.

When encountering movement disorders such as Parkinson's symptoms, irritability, tremor, unsteady gait, should immediately stop using trimpol mR.

These cases are rarely occurring and often recover after stopping the drug. Most patients recover after stopping the drug for about 4 months. If Parkinson's symptoms continue to happen for more than 4 months after the stop, it is necessary to consult neurologists.

may have a self, unstable gait or hypotension, especially in patients who are taking drugs to treat hypertension.

Be careful when prescribing trimpol mR for patients with high sensitivity levels such as:

Patients with average renal failure.

Patients over 75 years old.

The ability to drive and operate machinery

trimpol mR can cause symptoms such as dizziness and drowsiness, so it can affect the ability to drive and operate machinery.

Pregnancy

There is no data on the use of trimetazidin for pregnant women. Animal studies do not show direct or indirect effects on fertility. To prevent, it is better not to use trimetazidin during pregnancy.

The period of breastfeeding

It is unclear whether trimetazidin is excreted through breast milk or not, so it is impossible to eliminate the risk of babies. Trimetazidin should not be used during breastfeeding.

Drug interaction

There is no document on interactions between trimetazidin and other drugs or foods. Trimetazidin can be used copper. With heparin, calciumine, oral anticoagulant, drugs for lipid metabolic disorders, acetylsalicylic acid, beta blockers, calcium channel blockers, digitals glycoside.

Storage

Store at a temperature not exceeding 30 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.